OTULIN

Understanding Entity Pages

This page aggregates everything SciDEX knows about OTULIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Gene page for OTULIN — OTU deubiquitinase with linear linkage specificity, regulator of NF-κB and linear ubiquitin chains

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graph TD
    OTULIN["<b>OTULIN</b>"]
    Inflammation{"Inflammation"}
    OTULIN -->|"activates"| Inflammation
    Als{"Als"}
    OTULIN -->|"activates"| Als
    Ms{"Ms"}
    OTULIN -->|"activates"| Ms
    NFKB["NFKB"]
    OTULIN -->|"activates"| NFKB
    IKBKG["IKBKG"]
    OTULIN -->|"activates"| IKBKG
    Lysosomal_Degradation(["Lysosomal Degradation"])
    OTULIN -->|"activates"| Lysosomal_Degradation
    Nf__b(["Nf-Kappab"])
    OTULIN -->|"activates"| Nf__b
    neurodegeneration["neurodegeneration"]
    OTULIN -->|"implicated in"| neurodegeneration
    PINK1["PINK1"]
    PINK1 -->|"activates"| OTULIN
    NF__B["NF-KappaB"]
    NF__B -->|"activates"| OTULIN
    TNF["TNF"]
    TNF -->|"activates"| OTULIN
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| OTULIN
    MITOCHONDRIA["MITOCHONDRIA"]
    MITOCHONDRIA -->|"activates"| OTULIN
    AND["AND"]
    AND -->|"activates"| OTULIN
    style OTULIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0