Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P21CIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | P21CIP1 |
| Key Genes/Proteins | FAS, INFLAMMATION, BCL2L1, BAK1, MMP1, AGING |
| Related Diseases | Aging, Obesity, Inflammation, Diabetes, Alzheimer |
| Related Pathways | Apoptosis |
Knowledge base pages for this entity
graph TD
P21CIP1["P21CIP1"]
P21CIP1 -->|"regulates"| Aging["Aging"]
P21CIP1 -->|"regulates"| Obesity["Obesity"]
P21CIP1 -->|"regulates"| Inflammation["Inflammation"]
P21CIP1 -->|"regulates"| Diabetes["Diabetes"]
P21CIP1 -->|"regulates"| Alzheimer["Alzheimer"]
P21CIP1 -->|"regulates"| ALS["ALS"]
P21CIP1 -.biomarker for.-> Senescence["Senescence"]
P21CIP1 -->|"regulates"| Als["Als"]
RB1["RB1"] -->|"regulates"| P21CIP1
APOPTOSIS["APOPTOSIS"] -.biomarker for.-> P21CIP1
P16INK4A["P16INK4A"] -.biomarker for.-> P21CIP1
GENES["GENES"] -->|"regulates"| P21CIP1
ALZHEIMER["ALZHEIMER"] -->|"regulates"| P21CIP1
BCL2L1["BCL2L1"] -.biomarker for.-> P21CIP1
FAS["FAS"] -->|"regulates"| P21CIP1
AGING["AGING"] -->|"regulates"| P21CIP1| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | regulates | disease | 0.65 |
| Obesity | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Senescence | biomarker_for | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| FAS | regulates | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| BCL2L1 | biomarker_for | gene | 0.60 |
| BAK1 | biomarker_for | gene | 0.60 |
| MMP1 | regulates | gene | 0.60 |
| AGING | regulates | gene | 0.60 |
| Apoptosis | biomarker_for | pathway | 0.60 |
| GENES | regulates | gene | 0.60 |
| P16INK4A | biomarker_for | gene | 0.60 |
| AND | biomarker_for | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| APOPTOSIS | biomarker_for | gene | 0.60 |
| T Cell | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||