entity

PA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

30Hypotheses

30Analyses

1Outgoing

0Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Outgoing (1)

Target	Relation	Type	Str
STING1	activates	protein	0.72

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound to restore hippo	0.709	Alzheimer's disease	Circuit-level neural dynamics in neurode
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa	0.700	-	Do β-amyloid plaques and neurofibrillary
Closed-loop tACS targeting EC-II SST interneurons to block t	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.697	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95	0.695	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop transcranial focused ultrasound with 40Hz gamma	0.689	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy	0.681	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.677	Alzheimer's disease	Circuit-level neural dynamics in neurode
H2: Indole-3-Propionate (IPA) as the Actual Neuroprotective	0.675	neurodegeneration	How does engineered C. butyricum cross t
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.670	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.660	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial alternating current stimulation to	0.639	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Microglial TREM2-SYK Pathway Enhancement	0.626	neurodegeneration	Cell type vulnerability in Alzheimers Di
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
Integrated Biomarker Panel for Therapeutic Window Identifica	0.615	neurodegeneration	What are the precise temporal dynamics o
Closed-loop transcranial focused ultrasound to restore hippo	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.612	Alzheimer's disease	Circuit-level neural dynamics in neurode
Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbate	0.610	-	Do β-amyloid plaques and neurofibrillary
DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici	0.609	neurodegeneration	Should microtubule-stabilizing drugs be
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic
Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Choli	0.600	-	Do β-amyloid plaques and neurofibrillary
HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43	0.598	neurodegeneration	What is the therapeutic window between i
H7: Enteric Nervous System Alpha-Synuclein Propagation Block	0.595	neurodegeneration	How does engineered C. butyricum cross t
Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Ove	0.592	neurodegeneration	Epigenetic reprogramming in aging neuron
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.578	Alzheimer's disease	Circuit-level neural dynamics in neurode
TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gam	0.577	neurodegeneration	RNA binding protein dysregulation across
PARP1 Inhibition Therapy	0.575	neurodegeneration	TDP-43 phase separation therapeutics for
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.569	neurodegeneration	What is the molecular mechanism by which

Mentioning Analyses (30)

Scientific analyses that reference this entity

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-16 | 0 hypotheses

Does APOE4 drive tau propagation

neurodegeneration | 2026-04-15 | 0 hypotheses

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.576

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026	0
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026	0
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026	0
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026	0
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026	0
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026	0
Zhi-Gan Formula improved insomnia and anxiety comorbidity in a mouse model via P [PMID:41525914]	Liu R, Wu Z, Yin Y, Song C, Zhang C et a	J Ethnopharmacol	2026	0
Triterpenoid saponins from Platycodon grandiflorus exhibit antidepressant-like e [PMID:41539634]	Yoon S, Chun E, Iqbal H, Kim SH, Kim SY	J Ethnopharmacol	2026	0
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026	0
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026	0
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026	0
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483]	Alfateh M, Vasconcelos C, Choker AH, Moh	Int J Biol Macromol	2026	0
AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583]	Takahashi K, Kurokawa K, Kawaguchi R, Ta	Neurochem Int	2026	0
Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsatur [PMID:41937329]	Akanchise T, Luo F, Angelov B, Deng Y, A	Adv Healthc Mater	2026	0
Single transient exposure to low-frequency low-intensity electrical stimulation [PMID:41942002]	Marcotto GS, Borghetti M, Bitraj J, Cava	Neuropharmacology	2026	0
Serpina1e mediates the exercise-induced enhancement of hippocampal memory in mal [PMID:41957371]	Kim H, Shin S, Han J, Yun K, Kim JS et a	Nat Commun	2026	0

PA

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Sleep and Circadian Dysfunction in Alzheimer's Disease

nimodipine-als

GRIA3 Gene

GSK-3β in Neurodegeneration

oxidative-stress-comparison

Neurotrophin Signaling Pathways in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

Sulforaphane and Nrf2 Activation for Neuroprotection

deferiprone-neurodegeneration

fitbit

FEEMSA Study: Laryngopharyngeal Function in Neurodegenerative Diseases (NCT04706234)

Stargardt Disease

Synucleinopathies

metal-ion-synuclein-mitochondria-axis-parkinsons

NPAS3 Gene

Non-Homologous End Joining in Neurodegeneration

mitophagy-defect

Outgoing (1)

Incoming (0)

Targeting Hypotheses (30)

Mentioning Analyses (30)

Does APOE4 drive tau propagation

Does APOE4 drive tau propagation

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

What are the specific molecular determinants that govern tau strain selection du

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

Are age-related static epigenetic patterns pathogenic or protective compensatory

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What is the temporal sequence of TREM2 signaling transition from protective to i

Are interneuron oscillation deficits compensatory responses or primary pathologi

What are the precise temporal dynamics of astrocyte ketone production decline du

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

How does engineered C. butyricum cross the blood-brain barrier to directly bind

What are the physiological functions of BACE1 beyond APP processing that could c

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

What upstream mechanisms trigger p53 activation specifically in response to poly

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

What molecular mechanisms drive the transition from acute to persistent neuroinf

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

Related Papers (20)