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The debate revealed a critical gap: while PINK1/PARKIN deficiency correlates wit

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

The debate revealed a critical gap: while excitatory neurons show mitochondrial

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

The debate revealed conflicting therapeutic approaches - enhancing DNA repair ve

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Partially Irreversible

Score: 0.887 · unknown disease · 2026-04-12

## Mechanistic Overview The cholinergic hypothesis of Alzheimer's disease (AD) posits that early dysfunction and progre

Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95 palmitoylation stab

Score: 0.885 · alzheimers · 2026-04-05

## Mechanistic Overview The hypothesis proposes that stabilizing hippocampal CA3-CA1 synaptic function through DHHC2-me

Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhyth

Score: 0.869 · alzheimers · 2026-04-05

## Mechanistic Overview Parvalbumin-positive (PV+) fast-spiking interneurons in entorhinal cortex layers II–III generat

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.865 · alzheimers · 2026-04-05

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct

Optogenetic restoration of hippocampal gamma oscillations via selective PV inter

Score: 0.865 · alzheimers · 2026-04-07

## Mechanistic Overview Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activatio

J-protein co-chaperone system mediates selective autophagy targeting of pathogen

Score: 0.831 · protein-biochemistry · 2026-04-28

**Molecular Mechanism and Rationale** The J-protein co-chaperone system functions as a critical autophagy adapter mecha

Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscilla

Score: 0.827 · alzheimers · 2026-04-16

## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymph

Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

Score: 0.827 · alzheimers · 2026-04-07

## Mechanistic Overview Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to resto

Gamma entrainment repairs cross-regional phase-amplitude coupling via CA1 Schaff

Score: 0.826 · alzheimers · 2026-04-28

Auditory 40 Hz entrainment applied during NREM sleep consolidates temporal coupling between hippocampal theta oscillatio

Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuro

Score: 0.824 · neurodegeneration · 2026-04-05

## Mechanistic Overview Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in

Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake

Score: 0.822 · neuroscience · 2026-04-22

**Molecular Mechanism and Rationale** The pathological spread of tau protein aggregates represents a central mechanism

Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation

Score: 0.820 · alzheimers · 2026-04-02

## Mechanistic Overview Hippocampal CA3-CA1 circuit rescue via neurogenesis and synaptic preservation starts from the cl

HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase

Score: 0.820 · neurodegeneration · 2026-04-13

## Mechanistic Overview HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation start