protein 2,974 words KG: HNRNPA1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

HNRNPA1 Protein

🔬 Protein Info
Gene SymbolHNRNPA1
AliasesPage for HNRNPA1
Chromosome12q13.13
FunctionIn neurons and other cell types, hnRNP A1 plays critical roles in multiple aspects of RNA metabolism and cellular stress response:
Primary ExpressionUbiquitous, high in brain and muscle
Subcellular Localization</strong></td><td>Nucleus, cytoplasm, stress granules</td></tr>
Molecular Weight38 kDa
Amino Acids372 aa
PathwaysAlpha-Synuclein, Er Stress, Synaptic Plasticity
UniProt IDP09651
NCBI Gene ID3178
Ensembl IDENSG00000166086
OMIM164017
GeneCardsHNRNPA1
Human Protein AtlasHNRNPA1
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Anxiety, Cancer, Carcinoma, Dementia
Known Drugs/CompoundsPACLITAXEL
InteractionsALOX15, USP7, RANK, RANKL, CALCOCO2, NDP52
KG Connections452 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
PARP1 Inhibition Therapy
Score: 0.58
Phase-Separated Organelle Targeting
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Autophagosome Maturation Checkpoint Control
Score: 0.49

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: expressed_in
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: stabilizes

Knowledge Graph (12 edges)

HNRNPA1 inhibits ALOX15
HNRNPA1 associated_with VALOSIN
HNRNPA1 inhibits USP7
HNRNPA1 associated_with VCP
HNRNPA1 associated_with TIA1
HNRNPA1 contributes_to VCP
HNRNPA1 activates RANK
HNRNPA1 activates RANKL
HNRNPA1 contributes_to TIA1
HNRNPA1 activates CALCOCO2