Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HYPOXIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HYPOXIA |
| Key Genes/Proteins | C3, C3AR1, ITGA2B, PPARGC1A |
| Related Diseases | BBB |
| Related Pathways | NF-KB |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
HYPOXIA["HYPOXIA"]
HYPOXIA -->|"activates"| PABP1_eIF4B_Complex["PABP1/eIF4B Complex"]
HYPOXIA -->|"causes"| Blood_Brain_Barrier_Injury["Blood-Brain Barrier Injury"]
HYPOXIA -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
HYPOXIA -->|"causes"| Blood_Brain_Barrier["Blood-Brain Barrier"]
HYPOXIA -->|"upregulates"| LINC00599["LINC00599"]
HYPOXIA -->|"activates"| Autophagy["Autophagy"]
HYPOXIA -->|"contributes to"| Myocardial_Injury["Myocardial Injury"]
HYPOXIA -->|"activates"| CAV1["CAV1"]
Chronic_Obstructive_Sleep_Apne["Chronic Obstructive Sleep Apnea"] -->|"causes"| HYPOXIA
HIF1A["HIF1A"] -->|"mediates"| HYPOXIA
LINC00599 -->|"upregulates"| HYPOXIA
ADORA2B["ADORA2B"] -->|"upregulates"| HYPOXIA| Source | Relation | Type | Str |
|---|---|---|---|
| HIF1A | mediates | entity | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis | 0.575 | neurodegeneration | What molecular mechanism causes VCP muta |
| Perinatal Hypoxia-Primed Microglia Targeting | 0.385 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.548
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.610
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The effect of ponicidin on CFA-induced chronic inflammatory pain and its mechani [PMID:40093024] | Wang P, Jiang H, Yao J, He G, Tao T et a | Front Med (Lausanne) | 2025 | 0 |
| Norsesquiterpenes from the stems and leaves of Pinellia pedatisecta Schott. [PMID:40543640] | Chen X, Cao YG, Chi FG, Liu YL, Ye KL et | Phytochemistry | 2025 | 0 |
| SCG5 and MITF may be novel markers of copper metabolism immunorelevance in Alzhe [PMID:38871989] | Zhuang X, Xia Y, Liu Y, Guo T, Xia Z et | Sci Rep | 2024 | 0 |
| Is there a future for andrographolide to be an anti-inflammatory drug? Decipheri [PMID:28377280] | Tan WSD, Liao W, Zhou S, Wong WSF | Biochem Pharmacol | 2017 | 0 |
| Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transge [PMID:28381639] | Singh SP, Chand HS, Langley RJ, Mishra N | J Immunol | 2017 | 0 |