concept

HIF-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIF-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

147Connections

1Hypotheses

1Analyses

1Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	HIF-1
Key Genes/Proteins	VEGF

Wiki Pages (16)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HIF_1["HIF-1"]
    style HIF_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HIF_1 -->|"activates"| Als["Als"]
    HIF_1 -->|"activates"| Cancer["Cancer"]
    HIF_1 -->|"activates"| Ferroptosis["Ferroptosis"]
    HIF_1 -.->|"inhibits"| Ischemia["Ischemia"]
    HIF_1 -.->|"inhibits"| Fibrosis["Fibrosis"]
    HIF_1 -->|"activates"| Aging["Aging"]
    HIF_1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    TKT([TKT]) -->|"activates"| HIF_1
    IDH2([IDH2]) -->|"activates"| HIF_1
    TIGAR([TIGAR]) -->|"activates"| HIF_1
    FOXO([FOXO]) -->|"activates"| HIF_1
    HK2([HK2]) -->|"activates"| HIF_1
    MYC([MYC]) -->|"activates"| HIF_1
    PKM2([PKM2]) -->|"activates"| HIF_1
    GLUT1([GLUT1]) -->|"activates"| HIF_1
    GSK3([GSK3]) -->|"activates"| HIF_1
    MTORC1([MTORC1]) -->|"activates"| HIF_1

Outgoing (45)

Target	Relation	Type	Str
VEGF	upregulates	protein	0.85

Incoming (102)

Source	Relation	Type	Str
TKT	activates	gene	0.60
IDH2	activates	gene	0.60
TIGAR	activates	gene	0.60
HK2	activates	gene	0.60
MYC	activates	gene	0.60
FASN	activates	gene	0.60
HK1	activates	gene	0.60
HK2	inhibits	gene	0.60
G3BP1	activates	gene	0.60
SLC7A11	inhibits	gene	0.60
OCLN	activates	gene	0.60
HMOX1	activates	gene	0.60
CD4	activates	gene	0.60
ABCA7	regulates	gene	0.60
LPL	regulates	gene	0.60
APOE4	regulates	gene	0.60
SYK	regulates	gene	0.60
TREM2	associated_with	gene	0.60
PPARG	regulates	gene	0.60
APOE	associated_with	gene	0.60
CNTN1	therapeutic_target	gene	0.60
NGF	therapeutic_target	gene	0.60
BDNF	activates	gene	0.60
HCRTR1	activates	gene	0.60
WIF1	inhibits	gene	0.60
FGF21	activates	gene	0.60
NRF2	activates	gene	0.60
CD4	regulates	gene	0.60
MTOR	activates	gene	0.60
MMP9	inhibits	gene	0.60
BAX	activates	gene	0.60
AKT	activates	gene	0.60
SRPK1	activates	gene	0.60
VEGF	activates	gene	0.60
MMP2	inhibits	gene	0.60
SLC16A1	activates	gene	0.60
GBM	activates	gene	0.60
ANGPT1	associated_with	gene	0.60
PIK3R1	associated_with	gene	0.60
UCHL1	activates	gene	0.60
VEGFA	activates	gene	0.60
ANGPT1	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
SNCA	regulates	gene	0.60
PARK7	regulates	gene	0.60
CASPASE3	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
AQP1	expressed_in	gene	0.60
AQP4	expressed_in	gene	0.60
NBR1	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Targeting SASP-Complement Amplification Through HIF-1α Downs	0.610	neurodegeneration	What molecular mechanism causes VCP muta

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.610

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HIF-1

Understanding Entity Pages

Wiki Pages (16)

Therapeutics

epas1-protein

Hypoxia Response Pathway

HIF1AN — Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor

HIF/Hypoxia Signaling in Parkinson's Disease

HIF/Hypoxia Signaling in Parkinson's Disease

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

COX4I1

HIF-1α Protein

HIF-1α Protein - Hypoxia Inducible Factor 1-alpha

HIF-1α Stabilization Therapy

ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator

HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha

BNIP3 Gene

CNTN1 Gene