pathway

Parthanatos

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Parthanatos: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections
0Hypotheses
0Analyses
16Outgoing
7Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info
NameParthanatos
SummaryPage for Parthanatos in Neurodegeneration
Related DiseasesNeuron Loss, PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, ALS, Parkinson'S Disease

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Parthanatos in Neurodegeneration

mechanism · 6619 words

DNA Damage Response in Corticobasal Syndrome

mechanism · 3900 words

dna-damage-repair

mechanism · 3555 words

AIFM1 Gene

gene · 3251 words

Apoptosis Pathway in Neurodegeneration

mechanism · 3169 words

Apoptosis in Neurodegeneration

mechanism · 3147 words

Pathway Diagram

graph TD
    Parthanatos["Parthanatos"] -->|"contributes to"| Neuron_Loss["Neuron Loss"]
    style Neuron_Loss fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Parthanatos["Parthanatos"] -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Parthanatos["Parthanatos"] -->|"causes"| NEURON["NEURON"]
    style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Parthanatos["Parthanatos"] -->|"involved in"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Parthanatos["Parthanatos"] -->|"involved in"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Parthanatos["Parthanatos"] -->|"involved in"| ALS["ALS"]
    style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Parthanatos["Parthanatos"] -->|"involved in"| Huntington_s_Disease["Huntington's Disease"]
    style Huntington_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PARP_1["PARP-1"] -->|"mediates"| Parthanatos["Parthanatos"]
    style PARP_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AIF["AIF"] -->|"mediates"| Parthanatos["Parthanatos"]
    style AIF fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    PARP1["PARP1"] -->|"involved in"| Parthanatos["Parthanatos"]
    style PARP1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MIF["MIF"] -->|"mediates"| Parthanatos["Parthanatos"]
    style MIF fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Parp1_Inhibitors["Parp1 Inhibitors"] -.->|"inhibits"| Parthanatos["Parthanatos"]
    style Parp1_Inhibitors fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style Parthanatos fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (23)

TargetRelationTypeStr
Neuron Losscontributes_tophenotype0.95
Neuroinflammationcontributes_toprocess0.95
NEURONcausescell_type0.95
NEUROINFLAMMATIONmediatesprocess0.95
PARKINSON'S DISEASEinvolved_indisease0.95

Incoming (10)

SourceRelationTypeStr
PARP-1mediatesprotein0.90
AIFmediatesprotein0.90
AIFinvolved_inprotein0.90
MIFinvolved_inprotein0.90
MIFmediatesprotein0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found