concept

PRESENILIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRESENILIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

21Outgoing

12Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	Presenilin-1 (PS1)
Summary	Presenilin-1 (PS1)
Key Genes/Proteins	APP, BACE1, Presenilin, AMYLOID, ALZHEIMER'S DISEASE
Related Diseases	Alzheimer, ALS, Neuroinflammation, Inflammation, Als
Related Pathways	Cholesterol Metabolism, Amyloid, Neuroinflammatory

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Presenilin-1 (PS1)

entity · 1985 words

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Pathway Diagram

graph TD
    PRESENILIN1["PRESENILIN1"]
    PRESENILIN1 -->|"involved_in"| Calcium_Regulation["Calcium Regulation"]
    PRESENILIN1 -->|"inhibits"| Alzheimer["Alzheimer"]
    PRESENILIN1 -->|"inhibits"| ALS["ALS"]
    PRESENILIN1 -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    PRESENILIN1 -->|"inhibits"| Inflammation["Inflammation"]
    PRESENILIN1 -->|"inhibits"| Als["Als"]
    PRESENILIN1 -->|"inhibits"| AMYLOID["AMYLOID"]
    ALZHEIMER_DISEASE["ALZHEIMER DISEASE"] -->|"inhibits"| PRESENILIN1
    ALZHEIMER["ALZHEIMER"] -->|"inhibits"| PRESENILIN1
    APP["APP"] -->|"inhibits"| PRESENILIN1
    BACE1["BACE1"] -->|"inhibits"| PRESENILIN1
    AND["AND"] -->|"inhibits"| PRESENILIN1
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"inhibits"| PRESENILIN1
    INFLAMMATION["INFLAMMATION"] -->|"inhibits"| PRESENILIN1

Outgoing (21)

Target	Relation	Type	Str
Calcium Regulation	involved_in	process	0.80
Alzheimer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
APP	inhibits	gene	0.60
BACE1	inhibits	gene	0.60
Presenilin	inhibits	protein	0.60
AMYLOID	inhibits	gene	0.60
Cholesterol Metabolism	inhibits	pathway	0.60
Amyloid	inhibits	pathway	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
Neuroinflammatory	activates	pathway	0.60
Complement	activates	pathway	0.60
Cholesterol	associated_with	pathway	0.60
Amyloid Beta	inhibits	protein	0.60
Aβ	inhibits	protein	0.60
Cholesterol	transports	pathway	0.60
Raf	transports	protein	0.60

Incoming (12)

Source	Relation	Type	Str
APP	inhibits	gene	0.60
BACE1	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
ALZHEIMER DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
ALZHEIMER	activates	gene	0.60
PRESENILIN	inhibits	gene	0.60
AND	activates	gene	0.60
AMYLOID	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found