pathway

Neuroinflammatory

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Neuroinflammatory: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

730Connections

5Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

Neuroinflammatory is a biological pathway involved in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Aging, Alzheimer. Connected to 272 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Neuroinflammatory
Key Genes/Proteins	P2RY12, TMEM119, GAIN, MICROGLIA, TREM2, NEUROINFLAMMATION
Linked Hypotheses	7 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    P2RY12["P2RY12"] -->|"biomarker for"| Neuroinflammatory["Neuroinflammatory"]
    TMEM119["TMEM119"] -->|"biomarker for"| Neuroinflammatory["Neuroinflammatory"]
    GAIN["GAIN"] -->|"biomarker for"| Neuroinflammatory["Neuroinflammatory"]
    MICROGLIA["MICROGLIA"] -->|"associated"| Neuroinflammatory["Neuroinflammatory"]
    style Neuroinflammatory fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (66)

Target	Relation	Type	Str
MACROPHAGES	associated_with	concept	0.50
MONOCYTES	associated_with	concept	0.50
disease	activates	disease	0.50
CYTOKINE	activates	concept	0.50
FLAVONOIDS	regulates	concept	0.50
GLUCOSE METABOLISM	regulates	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
disease	causes	disease	0.50
disease	interacts_with	disease	0.50
disease	associated_with	disease	0.50
CEREBROSPINAL FLUID	associated_with	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
CYTOKINE	associated_with	concept	0.50
CYTOKINE	inhibits	concept	0.50
Microbiota	regulates	process	0.50
Gut Microbiota	regulates	process	0.50
Microbiota	activates	process	0.50
Chaperone	inhibits	pathway	0.50
Proteins	inhibits	protein	0.50
IPSC	associated_with	concept	0.50
NEURODEGENERATIVE DISEASE	activates	concept	0.50
Type 2 Diabetes	activates	disease	0.50
INSULIN	activates	concept	0.50
NEURODEGENERATIVE DISEASE	associated_with	concept	0.50
disease	regulates	disease	0.50
CARDIOVASCULAR DISEASE	interacts_with	concept	0.50
cGAS-STING pathway	activates	pathway	0.50
Nlrp3 Inflammasome	activates	pathway	0.50
Macrophage	activates	cell_type	0.50
MACROPHAGES	activates	concept	0.50
MAPK SIGNALING	inhibits	concept	0.50
CELL DEATH	regulates	concept	0.50
PROINFLAMMATORY CYTOKINES	associated_with	concept	0.50
ALZHEIMER'S	interacts_with	concept	0.50
Microbiota	associated_with	process	0.50
Gut Microbiota	associated_with	process	0.50
Hippocampus	activates	entity	0.50
Cognitive Impairment	activates	phenotype	0.50
ALZHEIMER'S	activates	concept	0.50
APP/PS1	inhibits	concept	0.50
AXON	associated_with	concept	0.50
Spinal Cord	activates	cell_type	0.50
SPINAL CORD INJURY	activates	concept	0.50
Macrophage	interacts_with	cell_type	0.50
Endothelial Cell	interacts_with	cell_type	0.50
Bipolar	interacts_with	disease	0.50
ENDOTHELIAL	interacts_with	concept	0.50
ISCHEMIC	associated_with	concept	0.50
ISCHEMIC STROKE	associated_with	concept	0.50

Incoming (664)

Source	Relation	Type	Str
P2RY12	biomarker_for	gene	0.60
TMEM119	biomarker_for	gene	0.60
GAIN	biomarker_for	gene	0.60
MICROGLIA	associated_with	gene	0.60
TREM2	biomarker_for	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
COMPLEMENT	inhibits	gene	0.60
NF-ΚB	activates	gene	0.60
C1Q	inhibits	gene	0.60
ANXIETY	activates	gene	0.60
MICROGLIA	activates	gene	0.60
GENES	activates	gene	0.60
C1QA	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
MOTOR NEURONS	activates	gene	0.60
NF-ΚB	associated_with	gene	0.60
MTDNA	activates	gene	0.60
DNA	activates	gene	0.60
IFN	associated_with	gene	0.60
MITOCHONDRIA	activates	gene	0.60
CGAS	activates	gene	0.60
ALS	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
STING	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
HK2	activates	gene	0.60
AMPK	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ALS	activates	gene	0.60
FLAVONOIDS	regulates	gene	0.60
PARKINSON	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
CRY	regulates	gene	0.60
BMAL1	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CLOCK	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
GENES	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
PER	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
TFR1	causes	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam	0.617	neurodegeneration	What are the mechanisms by which gut mic
GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R	0.498	neuroinflammation	Why do TAM receptors protect against neu
Cardiovascular-Neuroinflammatory Dual Targeting	0.462	neurodegeneration	Neuroinflammation and microglial priming
TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinf	0.444	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro	0.424	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
Decoding cell death signals in liver inflammation. [PMID:23567086]	Brenner C, Galluzzi L, Kepp O, Kroemer G	J Hepatol	2013	1
Benzo[a]pyrene promotes gastric cancer progression via activation of the Correa [PMID:41780474]	Tong J, Liu S, Du T, Liu W, Jin Z et al.	Ecotoxicol Environ Saf	2026	0
Wnt-dependent modulation of alveolar epithelial phenotypes and barrier function [PMID:41678947]	Lin YC, Igarashi M, Sakai Y, Nishikawa M	Biochem Biophys Res Commun	2026	0
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PK [PMID:40659086]	Li Z, Tan D, Lin J, Zhang T, Liu B et al	J Adv Res	2026	0
Celastrol treatment attenuates the inflammatory response in Alzheimer's disease [PMID:40762111]	Cao F, Zhang P, Zheng Z, Wang P, Wang Y	Neurol Res	2026	0
CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis [PMID:41519399]	Zhang Y, Wang J, Song Y, Chai J, Li L et	Biochem Pharmacol	2026	0
Panax ginseng-derived Exosome-like Nanoparticles Prevent LPS-induced Septic Shoc [PMID:41530048]	Kim Y, Kim YK, Lee S, Kim M, Lee SW et a	Mol Pharm	2026	0
Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081]	Qin H, Yang L, Du J, Xu X, Chen Z et al.	Int Immunopharmacol	2026	0
2'-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota M [PMID:41926238]	Chen J, Liang S, Liu D, Yang S, Yan Q et	J Agric Food Chem	2026	0
Leveraging intraperitoneal delivery of toll-like receptor agonists to treat peri [PMID:41926324]	Yan H, Chia D, Ernst S, Demuytere J, Cos	Expert Opin Drug Deliv	2026	0
Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877]	Miao J, Wang J, Zhou W, Guo J	Sci Rep	2026	0
Anti-carbamylated protein antibodies stabilize carbamylated Histone H3 to promot [PMID:41930627]	Nakabo S, Hanata N, Patino-Martinez E, H	Arthritis Rheumatol	2026	0
In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV- [PMID:41931545]	Zheng N, Xu Y	PLoS Negl Trop Dis	2026	0
Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF. [PMID:41931597]	Ma B, Lyu W, Rizk J, Han X, Kjær M et al	Sci Immunol	2026	0
Reverse vaccinology and immunoinformatics Approaches Driven designing of a Novel [PMID:41934706]	Siddiquee NH, Al Mamun MA, Dremit TI, Ul	Hum Immunol	2026	0
MEX3B aggravates osteoarthritis progression by post-transcriptionally activating [PMID:41935341]	Fu Z, Huang Y, Zhang S, Chen J	J Orthop Surg Res	2026	0
Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876]	Chen F, Xue Y, Ma X, Chen L, Shao Z et a	Adv Sci (Weinh)	2026	0
Molecular characterization and immunoinformatics-based design of a multi-epitope [PMID:41949632]	Asim M, Makki HH	Antonie Van Leeuwenhoek	2026	0
Zearalenone causes female reproductive lipotoxicity through the ERα-CD36/TLR4 si [PMID:41957128]	Dai C, Fu W, Huang Y, Li T, Ma Z et al.	Commun Biol	2026	0

Neuroinflammatory

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Device Therapies Comparison for CBS/PSP

Pathway Diagram

Outgoing (66)

Incoming (664)

Targeting Hypotheses (5)

Mentioning Analyses (3)

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

Neuroinflammation and microglial priming in early Alzheimer's Disease

Neuroinflammation and microglial priming in early Alzheimer's Disease

Related Papers (20)

Neuroinflammatory

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Device Therapies Comparison for CBS/PSP

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

neuroinflammation

Frontotemporal Dementia (FTD)

NTF4 Protein

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

CLCN10 — Chloride Voltage-Gated Channel 10

rasagiline

Blood-Brain Barrier Dysfunction in Neurodegeneration

APOC4 — Apolipoprotein C-IV

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

gabaergic-dysfunction

University of Heidelberg

Coenzyme Q10 for Neurodegeneration

Pathway Diagram

Outgoing (66)

Incoming (664)

Targeting Hypotheses (5)

Mentioning Analyses (3)

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

Neuroinflammation and microglial priming in early Alzheimer's Disease

Neuroinflammation and microglial priming in early Alzheimer's Disease

Related Papers (20)