pathway

Cholesterol Metabolism

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cholesterol Metabolism: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

365Connections

0Hypotheses

2Analyses

10Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	Cholesterol Metabolism
Key Genes/Proteins	ATAD3A, APOE4, SGMS1, ABCA1, ASTROCYTES, ALZHEIMER'S DISEASE
Related Diseases	ALZHEIMER'S DISEASE, Macrophage Senescence
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Cholesterol_Metabolism["Cholesterol Metabolism"] -->|"associated"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Cholesterol_Metabolism["Cholesterol Metabolism"] -->|"regulates"| CD8__T_Cell_Immunity["CD8+ T Cell Immunity"]
    style CD8__T_Cell_Immunity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Cholesterol_Metabolism["Cholesterol Metabolism"] -->|"causes"| Macrophage_Senescence["Macrophage Senescence"]
    style Macrophage_Senescence fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    APOE4["APOE4"] -->|"modulates"| Cholesterol_Metabolism["Cholesterol Metabolism"]
    style APOE4 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    SGMS1["SGMS1"] -->|"involved in"| Cholesterol_Metabolism["Cholesterol Metabolism"]
    style SGMS1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ABCA1["ABCA1"] -->|"activates"| Cholesterol_Metabolism["Cholesterol Metabolism"]
    style ABCA1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ASTROCYTES["ASTROCYTES"] -->|"activates"| Cholesterol_Metabolism["Cholesterol Metabolism"]
    style ASTROCYTES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE_1["ALZHEIMER'S DISEASE"] -->|"activates"| Cholesterol_Metabolism["Cholesterol Metabolism"]
    style ALZHEIMER_S_DISEASE_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Cholesterol_Metabolism fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (62)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	0.90
CD8+ T Cell Immunity	regulates	process	0.85
Macrophage Senescence	causes	phenotype	0.85
Oligodendrocyte	expressed_in	cell_type	0.85
Preimplantation Embryos	involved_in	cell_type	0.85
Tau-Mediated Degeneration	contributes_to	process	0.80
Neuron	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
Microglia	associated_with	cell_type	0.50

Incoming (303)

Source	Relation	Type	Str
ATAD3A	regulates	protein	0.95
APOE4	modulates	protein	0.90
SGMS1	involved_in	protein	0.88
ABCA1	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
JUN	activates	gene	0.60
APOE4	activates	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
APOE	activates	gene	0.60
TAU	activates	gene	0.60
APOE3	activates	gene	0.60
TAUOPATHY	activates	gene	0.60
LDL	inhibits	gene	0.60
LDLR	inhibits	gene	0.60
ERK	inhibits	gene	0.60
GENES	inhibits	gene	0.60
SREBP2	inhibits	gene	0.60
GPR146	inhibits	gene	0.60
LDLR	regulates	gene	0.60
CD8	regulates	gene	0.60
AND	activates	gene	0.60
AND	inhibits	gene	0.60
AGING	contributes_to	gene	0.60
NAD	activates	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
CD38	activates	gene	0.60
AND	contributes_to	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
SGMS1	contributes_to	gene	0.60
RAS	expressed_in	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AMYLOID	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
CYP46A1	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
APP	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
CYP46A1	regulates	gene	0.60
TAU	regulates	gene	0.60
ALZHEIMER	inhibits	gene	0.60
CYP46A1	associated_with	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.505

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Cholesterol Metabolism

Understanding Entity Pages

Wiki Pages (20)

Parkinson's Disease

APOC4 — Apolipoprotein C-IV

Coenzyme Q10 for Neurodegeneration

Niemann-Pick Disease Type C (NPC)

TDP-43 Proteinopathy

metabolic-dysfunction-neurodegeneration

Lipid Metabolism Dysfunction Comparison — AD/PD/ALS/FTD/HD

Metabolomic Alterations in PSP

Peroxisomal Dysfunction

er-stress-neurodegeneration

genetics

Lipid Metabolism Dysregulation in Neurodegeneration

Amyloid Precursor Protein (APP)

Gamma-Secretase Complex (γ-Secretase)

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

MSA Genetics and Risk Factors

niemann-pick-disease

Sphingolipid Metabolism in Neurodegeneration

Demyelination

Mechanisms Dashboard