gene

LATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

528Connections

7Hypotheses

30Analyses

50Outgoing

22Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	late
Aliases	late
Associated Diseases	ALZHEIMER, ALZHEIMER'S
KG Connections	374 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LATE["LATE"] -->|"associated"| RAB7["RAB7"]
    style RAB7 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -->|"associated"| RILP["RILP"]
    style RILP fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -.->|"inhibits"| RGS6["RGS6"]
    style RGS6 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -->|"associated"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -->|"expressed in"| TREM2["TREM2"]
    style TREM2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -.->|"inhibits"| RAD51["RAD51"]
    style RAD51 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LATE["LATE"] -->|"associated"| NEURODEGENERATION["NEURODEGENERATION"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Tdp_43["Tdp-43"] -->|"implicated in"| LATE["LATE"]
    style Tdp_43 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CANCER["CANCER"] -->|"associated"| LATE["LATE"]
    style CANCER fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    APOE["APOE"] -->|"associated"| LATE["LATE"]
    style APOE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    EIF2AK3["EIF2AK3"] -.->|"inhibits"| LATE["LATE"]
    style EIF2AK3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ERN1["ERN1"] -.->|"inhibits"| LATE["LATE"]
    style ERN1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style LATE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (481)

Target	Relation	Type	Str
RAB7	associated_with	entity	0.60
RILP	associated_with	entity	0.60
RGS6	inhibits	entity	0.60
NEUROINFLAMMATION	associated_with	entity	0.60
TREM2	expressed_in	entity	0.60
RAD51	inhibits	entity	0.60
NEURODEGENERATION	associated_with	entity	0.60
UNC5C	associated_with	entity	0.60
MTOR	activates	entity	0.60
NEURODEGENERATION	activates	entity	0.60
NEUROINFLAMMATION	activates	entity	0.60
VPS4A	inhibits	entity	0.60
UBIQUITIN	co_discussed	protein	0.40
G3BP1	co_discussed	gene	0.40
AUTOPHAGY	co_discussed	process	0.40
PROTEINS	co_discussed	protein	0.40
STING	co_discussed	gene	0.40
ACTB	co_discussed	gene	0.40
ACTIN	co_discussed	protein	0.40
ALS	co_discussed	disease	0.40
AMYOTROPHIC LATERAL SCLEROSIS	co_discussed	gene	0.40
BECN1	co_discussed	gene	0.40
C9ORF72	co_discussed	gene	0.40
SMCR8	co_discussed	gene	0.40
CALCOCO2	co_discussed	gene	0.40
NDP52	co_discussed	gene	0.40
FTD	co_discussed	disease	0.40
DEMENTIA	co_discussed	gene	0.40
FUS	co_discussed	protein	0.40
RNA	co_discussed	gene	0.40
MAP1LC3	co_discussed	gene	0.40
LC3	co_discussed	protein	0.40
NBR1	co_discussed	gene	0.40
NES	co_discussed	protein	0.40
GNAL	co_discussed	gene	0.40
OPTN	co_discussed	gene	0.40
OPTINEURIN	co_discussed	protein	0.40
SQSTM1	co_discussed	gene	0.40
P62	co_discussed	protein	0.40
TAX1BP1	co_discussed	gene	0.40
TOLLIP	co_discussed	gene	0.40
ULK1	co_discussed	gene	0.40
MACROPHAGES	co_discussed	cell_type	0.40
C1QA	co_discussed	gene	0.40
GRN	co_discussed	gene	0.40
CTSB	co_discussed	gene	0.40
AMYLOID	co_discussed	gene	0.40
ATHEROSCLEROSIS	co_discussed	disease	0.40
ATG	co_discussed	gene	0.40
CHMP2B	co_discussed	gene	0.40

Incoming (47)

Source	Relation	Type	Str
Tdp-43	implicated_in	protein	0.90
CANCER	associated_with	entity	0.60
APOE	associated_with	entity	0.60
APOE	upregulates	entity	0.60
EIF2AK3	inhibits	entity	0.60
ERN1	inhibits	entity	0.60
BIN1	associated_with	entity	0.60
AKT	activates	entity	0.60
APOE	expressed_in	entity	0.60
DEPRESSION	associated_with	entity	0.60
CANCER	activates	entity	0.60
SPP1	co_discussed	gene	0.40
MICROGLIA	co_discussed	cell_type	0.40
SYNA	co_discussed	gene	0.40
C1Q	co_discussed	gene	0.40
MYOT	co_discussed	gene	0.40
NEURON	co_discussed	gene	0.40
RELA	co_discussed	gene	0.40
NEURODEGENERATIVE DISEASES	co_discussed	disease	0.40
P2RY12	co_discussed	gene	0.40
ABCD3	co_discussed	gene	0.40
ALZHEIMER DISEASE	co_discussed	gene	0.40

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic
CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli	0.569	neurodegeneration	Lipid raft composition changes in synapt
Near-infrared light therapy stimulates COX4-dependent mitoch	0.514	neurodegeneration	Mitochondrial transfer between astrocyte
Layer V excitatory neurons show selectively enhanced vulnera	0.510	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Microglial TREM2 downregulation impairs damage-associated re	0.507	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

Glycosaminoglycan Template Disruption Approach	0.464	neurodegeneration	Protein aggregation cross-seeding across
TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinf	0.444	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (30)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.542

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

neurodegeneration | 2026-04-15 | 0 hypotheses

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096]	Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li	Autophagy	2023	1
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains. [PMID:32722981]	Wu X, Zheng Y, Liu M, Li Y, Ma S, Tang W	Autophagy	2021	1
SIRT5 regulation of ammonia-induced autophagy and mitophagy. [PMID:25700560]	Polletta L, Vernucci E, Carnevale I, Arc	Autophagy	2015	1
Enhancing the efficiency of bone tissue regeneration by using a 3D printed scaff [PMID:41435437]	Ku CY, Chen YH, Lin CM, Chu YH, Ho YJ, L	Biomedical materials (Bristol,	2026	0
PRKAB2 as a tumor suppressor in renal cell carcinoma: inhibiting mitophagy via t [PMID:41612594]	Chen K, Zhang Y, Ruan H, Wei Z, Wang K,	Autophagy	2026	0
ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818]	["Li X", "Huang J", "Zhou Y", "Chen X",	International journal of pharm	2026	0
Single-Cell RNA Sequencing and Network Pharmacology Reveal the Potential Role of [PMID:41610872]	["Niu J", "Wang L", "Qi J", "Lu G"]	The journal of gene medicine	2026	0
Integrated Profiling of DEHP-Induced Hippocampal Neurotoxicity in Adult Female R [PMID:41600627]	Bai J, Li J, Tang L, Sun W, Gao F, Zhang	Toxics	2026	0
Functional and Molecular Characterization of Melamine-Induced Disruption of Huma [PMID:41596180]	["Luongo F", "Annunzi E", "Ponchia R", "	Antioxidants (Basel, Switzerla	2026	0
Exploring the lactate-metabolism related characteristics during the development [PMID:41815173]	Wang C, Zhang R, Li S, Kang Z, Xia S, Li	Translational cancer research	2026	0
Developmental toxicity of carboxylated microplastics in zebrafish mediated by mi [PMID:41265820]	["Li Y", "Ni Y", "Dong C", "Zhang J", "G	Environmental pollution (Barki	2026	0
Complex IV deficiency due to COX4I1 deep intronic and de novo variants results i [PMID:41203052]	Ugarteburu O, Farré-Tarrats L, Muñoz-Puj	Mitochondrion	2026	0
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026	0
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026	0
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026	0
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750]	Yang X, Zhao Y, Liu W, Feng J, Wu X et a	J Ethnopharmacol	2026	0
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvir [PMID:41576929]	Mateus-Tique J, Lakshmi A, Singh B, Iyer	Cancer Cell	2026	0
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026	0
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026	0
Large-scale single-cell analysis and in silico perturbation reveal dynamic evolu [PMID:41617928]	Xia P, Shuang S, Fu D, Liu L, Yang D et	NPJ Precis Oncol	2026	0

LATE

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

Alpha-Synuclein Pathology

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nimodipine-als

NPM1 Gene

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Alzheimer's Disease

PD Cure Roadmap

Pathway Diagram

Outgoing (481)

Incoming (47)

Targeting Hypotheses (7)

Mentioning Analyses (30)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

How do the seven novel ALS genes function in animal models to cause neurodegener

How does HDAC1/2 deletion specifically enhance microglial amyloid phagocytosis c

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

What are the specific molecular mechanisms by which peripheral monocytes cross t

Does human glymphatic function show clinically relevant circadian variation like

What specific gene expression signatures in aging mouse white matter predict hum

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

Does structural 'normalization' of APOE4 domain interactions actually improve am

What are the specific molecular mechanisms linking ADCY8 to spatial memory conso

Do stellate neurons express unique α7 nicotinic receptor subtypes that could ena

Why do clinical manifestations overlap despite distinct underlying etiologies in

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Can circadian interventions reverse microglial priming independent of sleep disr

What are the specific pathophysiological mechanisms underlying uncommon immune-m

What determines the spatial organization of autophagy receptors at stress granul

What are the specific molecular mechanisms by which C1Q components drive atheros

Do perinatal immune challenges create persistent epigenetic modifications that p

What determines P2RY12 receptor expression/activity specifically in VSMCs during

How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liq

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Related Papers (20)