gene

RXRB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RXRB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
6Outgoing
9Incoming

Summary

Retinoid X Receptor Beta - a nuclear receptor involved in retinoid signaling, heterodimer formation, and neurodegenerative disease pathogenesis

View on Wiki →

🧬 Gene Info
Gene SymbolRXRB
AliasesRetinoid X Receptor Beta
Chromosome6p21.3
Protein TypeReceptor
Functionis a member of the nuclear receptor superfamily that serves as a central partner for multiple other nuclear receptors, forming functional heterodimers that regulate diverse gene programs.
Primary Expressionvarious peripheral tissues [1](https://pubmed
PathwaysAkt, Mapk, Sphingolipid
Ensembl IDENSG00000143207
GeneCardsRXRB
Human Protein AtlasRXRB
gene = RXRBname = Retinoid X Receptor Beta
ncbi_gene_id = 6257ensembl = ENSG00000143207
RARα/β/γHeterodimer
PPARα/γ/δHeterodimer
LXRα/βHeterodimer
Associated Diseasesneurodegeneration
KG Connections15 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RXRB Gene

gene · 2533 words

Genes

index · 271 words

Pathway Diagram

graph TD
    RXRB["RXRB"]
    Inflammation{"Inflammation"}
    RXRB -->|"regulates"| Inflammation
    Ms{"Ms"}
    RXRB -->|"therapeutic_target"| Ms
    INFLAMMATION["INFLAMMATION"]
    RXRB -->|"regulates"| INFLAMMATION
    Sphingolipid(["Sphingolipid"])
    RXRB -->|"regulates"| Sphingolipid
    Akt(["Akt"])
    RXRB -->|"regulates"| Akt
    Mapk(["Mapk"])
    RXRB -->|"regulates"| Mapk
    MAPK3["MAPK3"]
    MAPK3 -->|"regulates"| RXRB
    MAPK["MAPK"]
    MAPK -->|"regulates"| RXRB
    RXRA["RXRA"]
    RXRA -->|"regulates"| RXRB
    PPARA["PPARA"]
    PPARA -->|"regulates"| RXRB
    AKT1["AKT1"]
    AKT1 -->|"regulates"| RXRB
    MAPK1["MAPK1"]
    MAPK1 -->|"regulates"| RXRB
    AND["AND"]
    AND -->|"regulates"| RXRB
    GENES["GENES"]
    GENES -->|"therapeutic_target"| RXRB
    PPARD["PPARD"]
    PPARD -->|"regulates"| RXRB

Outgoing (6)

TargetRelationTypeStr
Inflammationregulatesdisease0.65
Mstherapeutic_targetdisease0.65
INFLAMMATIONregulatesgene0.60
Sphingolipidregulatespathway0.60
Aktregulatespathway0.60

Incoming (9)

SourceRelationTypeStr
MAPK3regulatesgene0.60
RXRAregulatesgene0.60
PPARAregulatesgene0.60
AKT1regulatesgene0.60
MAPK1regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found