Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RXRB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Retinoid X Receptor Beta - a nuclear receptor involved in retinoid signaling, heterodimer formation, and neurodegenerative disease pathogenesis
| Gene Symbol | RXRB |
| Aliases | Retinoid X Receptor Beta |
| Chromosome | 6p21.3 |
| Protein Type | Receptor |
| Function | is a member of the nuclear receptor superfamily that serves as a central partner for multiple other nuclear receptors, forming functional heterodimers that regulate diverse gene programs. |
| Primary Expression | various peripheral tissues [1](https://pubmed |
| Pathways | Akt, Mapk, Sphingolipid |
| Ensembl ID | ENSG00000143207 |
| GeneCards | RXRB |
| Human Protein Atlas | RXRB |
| gene = RXRB | name = Retinoid X Receptor Beta |
| ncbi_gene_id = 6257 | ensembl = ENSG00000143207 |
| RARα/β/γ | Heterodimer |
| PPARα/γ/δ | Heterodimer |
| LXRα/β | Heterodimer |
| Associated Diseases | neurodegeneration |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RXRB["RXRB"]
Inflammation{"Inflammation"}
RXRB -->|"regulates"| Inflammation
Ms{"Ms"}
RXRB -->|"therapeutic_target"| Ms
INFLAMMATION["INFLAMMATION"]
RXRB -->|"regulates"| INFLAMMATION
Sphingolipid(["Sphingolipid"])
RXRB -->|"regulates"| Sphingolipid
Akt(["Akt"])
RXRB -->|"regulates"| Akt
Mapk(["Mapk"])
RXRB -->|"regulates"| Mapk
MAPK3["MAPK3"]
MAPK3 -->|"regulates"| RXRB
MAPK["MAPK"]
MAPK -->|"regulates"| RXRB
RXRA["RXRA"]
RXRA -->|"regulates"| RXRB
PPARA["PPARA"]
PPARA -->|"regulates"| RXRB
AKT1["AKT1"]
AKT1 -->|"regulates"| RXRB
MAPK1["MAPK1"]
MAPK1 -->|"regulates"| RXRB
AND["AND"]
AND -->|"regulates"| RXRB
GENES["GENES"]
GENES -->|"therapeutic_target"| RXRB
PPARD["PPARD"]
PPARD -->|"regulates"| RXRB| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | regulates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| INFLAMMATION | regulates | gene | 0.60 |
| Sphingolipid | regulates | pathway | 0.60 |
| Akt | regulates | pathway | 0.60 |
| Mapk | regulates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||