gene

MAPK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

444Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

MAPK3 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, associated with. Associated with Aging, Als, Alzheimer. Connected to 232 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolMAPK3
Full NameMitogen-Activated Protein Kinase 3
AliasesPage for MAPK3 Gene
Chromosome16p11.2
Protein FamilyMAP kinase family, CMGC group
Protein TypeKinase
Functionis a serine/threonine protein kinase encoded by the MAPK3 gene.
Subcellular LocalizationCytoplasm, Nucleus
Molecular Weight43 kDa
Amino Acids379 aa
PathwaysMAPK, mapk
UniProt IDP27361
GeneCardsMAPK3
Human Protein AtlasMAPK3
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Cancer
InteractionsNLRP3, ZAP70, TP53, CD19, EEF2, CCL5
KG Connections444 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: MAPK3 — AlphaFold P27361 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

MAPK3 Gene - ERK1

gene · 1372 words

erk-mapk-signaling-neurodegeneration

mechanism · 2988 words

ERK1 Protein

protein · 2891 words

ERK2 Protein

protein · 2838 words

MAP2K2 Gene

gene · 2515 words

MAPK4 Gene

gene · 1718 words

Pathway Diagram

graph TD
    MAPK3["MAPK3"]
    MAPK3 -->|"target for"| Cancer["Cancer"]
    MAPK3 -->|"target for"| Fibrosis["Fibrosis"]
    MAPK3 -->|"target for"| Als["Als"]
    MAPK3 -->|"target for"| Ms["Ms"]
    MAPK3 -->|"interacts"| Atherosclerosis["Atherosclerosis"]
    MAPK3 -->|"expressed in"| Longevity["Longevity"]
    AKT["AKT"] -->|"target for"| MAPK3
    CASP3["CASP3"] -->|"target for"| MAPK3
    PI3K["PI3K"] -->|"target for"| MAPK3
    CD4["CD4"] -->|"interacts"| MAPK3
    TP53["TP53"] -->|"target for"| MAPK3
    AKT1["AKT1"] -->|"target for"| MAPK3
    TNF["TNF"] -->|"target for"| MAPK3
    IL_6["IL-6"] -->|"target for"| MAPK3
    CANCER["CANCER"] -->|"target for"| MAPK3
    APOPTOSIS["APOPTOSIS"] -->|"target for"| MAPK3

Outgoing (330)

TargetRelationTypeStr
Mapktherapeutic_targetpathway1.00
Cytoplasm Localizationpromotesprocess0.90
Neurodegenerationinvolved_inprocess0.90
Atherosclerosisimplicated_indisease0.90
Endoplasmic Reticulum Stress Responsemediatesprocess0.88

Incoming (114)

SourceRelationTypeStr
Rosactivatesprocess0.90
FGF2activatesprotein0.90
SBPdownregulatesdrug0.90
KDELactivatesreceptor0.88
Cholixupregulatesentity0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found