Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MAPK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
MAPK3 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, associated with. Associated with Aging, Als, Alzheimer. Connected to 232 entities in the SciDEX knowledge graph.
| Gene Symbol | MAPK3 |
| Full Name | Mitogen-Activated Protein Kinase 3 |
| Aliases | Page for MAPK3 Gene |
| Chromosome | 16p11.2 |
| Protein Family | MAP kinase family, CMGC group |
| Protein Type | Kinase |
| Function | is a serine/threonine protein kinase encoded by the MAPK3 gene. |
| Subcellular Localization | Cytoplasm, Nucleus |
| Molecular Weight | 43 kDa |
| Amino Acids | 379 aa |
| Pathways | MAPK, mapk |
| UniProt ID | P27361 |
| GeneCards | MAPK3 |
| Human Protein Atlas | MAPK3 |
| Associated Diseases | ALS, Aging, Alzheimer, Atherosclerosis, Cancer |
| Interactions | NLRP3, ZAP70, TP53, CD19, EEF2, CCL5 |
| KG Connections | 444 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MAPK3["MAPK3"]
MAPK3 -->|"target for"| Cancer["Cancer"]
MAPK3 -->|"target for"| Fibrosis["Fibrosis"]
MAPK3 -->|"target for"| Als["Als"]
MAPK3 -->|"target for"| Ms["Ms"]
MAPK3 -->|"interacts"| Atherosclerosis["Atherosclerosis"]
MAPK3 -->|"expressed in"| Longevity["Longevity"]
AKT["AKT"] -->|"target for"| MAPK3
CASP3["CASP3"] -->|"target for"| MAPK3
PI3K["PI3K"] -->|"target for"| MAPK3
CD4["CD4"] -->|"interacts"| MAPK3
TP53["TP53"] -->|"target for"| MAPK3
AKT1["AKT1"] -->|"target for"| MAPK3
TNF["TNF"] -->|"target for"| MAPK3
IL_6["IL-6"] -->|"target for"| MAPK3
CANCER["CANCER"] -->|"target for"| MAPK3
APOPTOSIS["APOPTOSIS"] -->|"target for"| MAPK3| Target | Relation | Type | Str |
|---|---|---|---|
| Mapk | therapeutic_target | pathway | 1.00 |
| Cytoplasm Localization | promotes | process | 0.90 |
| Neurodegeneration | involved_in | process | 0.90 |
| Atherosclerosis | implicated_in | disease | 0.90 |
| Endoplasmic Reticulum Stress Response | mediates | process | 0.88 |
| Cancer-Related Signal Transduction | involved_in | pathway | 0.85 |
| TEAD1 | regulates | protein | 0.85 |
| TEAD | interacts_with | protein | 0.85 |
| Apoptosis | involved_in | process | 0.85 |
| cell-matrix dissociation | promotes | process | 0.82 |
| suspension proficiency | drives | phenotype | 0.81 |
| prostate injury | implicated_in | process | 0.80 |
| YAP1 | modulates | protein | 0.80 |
| Atherosclerosis | associated_with | disease | 0.80 |
| MAPK signaling | participates_in | pathway | 0.80 |
| EGFR | therapeutic_target | gene | 0.80 |
| AKT | therapeutic_target | gene | 0.80 |
| GENES | therapeutic_target | gene | 0.80 |
| Apoptosis | therapeutic_target | pathway | 0.80 |
| Cancer | therapeutic_target | disease | 0.75 |
| Als | therapeutic_target | disease | 0.75 |
| Inflammation | therapeutic_target | disease | 0.75 |
| JUN | therapeutic_target | gene | 0.70 |
| HSP90AA1 | therapeutic_target | gene | 0.70 |
| MAPK1 | associated_with | gene | 0.70 |
| MYC | therapeutic_target | gene | 0.70 |
| PI3K | therapeutic_target | gene | 0.70 |
| MMP9 | therapeutic_target | gene | 0.70 |
| TNF | therapeutic_target | gene | 0.70 |
| TP53 | therapeutic_target | gene | 0.70 |
| CDKN1A | therapeutic_target | gene | 0.70 |
| MAPK1 | activates | gene | 0.70 |
| MAPK1 | therapeutic_target | gene | 0.70 |
| AUTOPHAGY | activates | gene | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| Mapk | associated_with | pathway | 0.70 |
| AUTOPHAGY | therapeutic_target | gene | 0.70 |
| Autophagy | therapeutic_target | pathway | 0.70 |
| CANCER | therapeutic_target | gene | 0.70 |
| APOPTOSIS | therapeutic_target | gene | 0.70 |
| INFLAMMATION | therapeutic_target | gene | 0.70 |
| Mapk | activates | pathway | 0.70 |
| Pi3K/Akt | therapeutic_target | pathway | 0.70 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.70 |
| Fibrosis | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Atherosclerosis | interacts_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Ros | activates | process | 0.90 |
| FGF2 | activates | protein | 0.90 |
| SBP | downregulates | drug | 0.90 |
| KDEL | activates | receptor | 0.88 |
| Cholix | upregulates | entity | 0.85 |
| Shexiang Baoxin Pill | downregulates | drug | 0.85 |
| PRKCD | associated_with | gene | 0.80 |
| Scutellarein | downregulates | compound | 0.80 |
| CASP3 | therapeutic_target | gene | 0.70 |
| PI3K | therapeutic_target | gene | 0.70 |
| TNF | therapeutic_target | gene | 0.70 |
| APOPTOSIS | therapeutic_target | gene | 0.70 |
| AKT | therapeutic_target | gene | 0.60 |
| FYN | associated_with | gene | 0.60 |
| CD4 | interacts_with | gene | 0.60 |
| TP53 | therapeutic_target | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| STAT3 | therapeutic_target | gene | 0.60 |
| JUN | therapeutic_target | gene | 0.60 |
| TAB1 | activates | protein | 0.60 |
| VEGFA | therapeutic_target | gene | 0.60 |
| JAK2 | therapeutic_target | gene | 0.60 |
| PIK3CA | therapeutic_target | gene | 0.60 |
| HRAS | therapeutic_target | gene | 0.60 |
| EGFR | therapeutic_target | gene | 0.60 |
| ERK1 | activates | gene | 0.60 |
| ERK2 | activates | gene | 0.60 |
| ERK1 | associated_with | gene | 0.60 |
| TRIM16 | implicated_in | gene | 0.60 |
| ERK2 | associated_with | gene | 0.60 |
| BIRC5 | therapeutic_target | gene | 0.60 |
| RAF1 | therapeutic_target | gene | 0.60 |
| MMP14 | therapeutic_target | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| SRC | therapeutic_target | gene | 0.60 |
| HSP90AA1 | therapeutic_target | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| IFNG | therapeutic_target | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| SRC | interacts_with | gene | 0.60 |
| AKT1 | interacts_with | gene | 0.60 |
| ESR1 | therapeutic_target | gene | 0.60 |
| PIK3R1 | therapeutic_target | gene | 0.60 |
| AKT | causes | gene | 0.60 |
| MAPK1 | therapeutic_target | gene | 0.60 |
| PIK3R1 | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| CTNNB1 | activates | gene | 0.60 |
| MAPK1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||