PPARA

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPARA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PPARA is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, associated with. Associated with AD, ADH, AMI. Connected to 280 entities in the SciDEX knowledge graph.

View on Wiki →

flowchart TD
    PPARGC1A["PPARGC1A<br/>PGC-1alpha<br/>Master Regulator"]
    PPARA["PPARA<br/>Peroxisome Proliferator<br/>Activated Receptor alpha"]
    TFEB["TFEB<br/>Transcription Factor EB<br/>Autophagy Master Regulator"]
    autophagy["Autophagy<br/>Cellular Clearance<br/>Process"]
    MAP1LC3B["MAP1LC3B<br/>LC3B<br/>Autophagosome Marker"]
    APP["APP<br/>Amyloid Precursor<br/>Protein"]
    Abeta["Abeta<br/>Amyloid Beta<br/>Plaques"]
    gemfibrozil["Gemfibrozil<br/>PPARA Agonist<br/>Drug"]
    Wy14643["Wy-14643<br/>PPARA Agonist<br/>Compound"]
    JMJD3["JMJD3<br/>Histone Demethylase<br/>Epigenetic Regulator"]
    alzheimers["Alzheimer's Disease<br/>Neurodegeneration"]
    inflammation["Neuroinflammation<br/>Pathological Process"]
    metabolism["Metabolic<br/>Dysfunction"]
    anxiety["Anxiety<br/>Behavioral Symptoms"]

    PPARGC1A --|"activates"|--> PPARA
    gemfibrozil --|"activates"|--> PPARA
    Wy14643 --|"activates"|--> PPARA
    JMJD3 --|"interacts with"|--> PPARA
    
    PPARA --|"regulates"|--> TFEB
    PPARA --|"activates"|--> MAP1LC3B
    TFEB --|"promotes"|--> autophagy
    MAP1LC3B --|"facilitates"|--> autophagy
    
    PPARA --|"regulates"|--> APP
    APP --|"produces"|--> Abeta
    autophagy --|"degrades"|--> Abeta
    
    PPARA --|"prevents"|--> alzheimers
    PPARA --|"reduces"|--> inflammation
    PPARA --|"inhibits"|--> anxiety
    
    Abeta --|"causes"|--> alzheimers
    inflammation --|"contributes to"|--> alzheimers
    metabolism --|"affects"|--> alzheimers

    style PPARA fill:#006494
    style TFEB fill:#1b5e20
    style autophagy fill:#1b5e20
    style MAP1LC3B fill:#1b5e20
    style gemfibrozil fill:#1b5e20
    style Wy14643 fill:#1b5e20
    style PPARGC1A fill:#4a1a6b
    style JMJD3 fill:#4a1a6b
    style alzheimers fill:#ef5350
    style Abeta fill:#ef5350
    style inflammation fill:#ef5350
    style APP fill:#ef5350
    style anxiety fill:#5d4400
    style metabolism fill:#5d4400