RXRA

Understanding Entity Pages

This page aggregates everything SciDEX knows about RXRA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Retinoid X Receptor Alpha - critical nuclear receptor that heterodimerizes with multiple receptors (PPAR, RAR, VDR, TR) to regulate lipid metabolism, neuroprotection, and gene expression in neurodegenerative diseases

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graph TD
    RXRA["<b>RXRA</b>"]
    Ms{"Ms"}
    RXRA -->|"therapeutic target"| Ms
    Als{"Als"}
    RXRA -->|"interacts with"| Als
    HSP90AA1["HSP90AA1"]
    RXRA -->|"interacts with"| HSP90AA1
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    RXRA -->|"therapeutic target"| MITOCHONDRIAL_DYSFUNCTION
    MAPK14["MAPK14"]
    RXRA -->|"associated with"| MAPK14
    MDM2["MDM2"]
    RXRA -->|"interacts with"| MDM2
    APOPTOSIS["APOPTOSIS"]
    RXRA -->|"therapeutic target"| APOPTOSIS
    RAF1["RAF1"]
    RXRA -->|"associated with"| RAF1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    RXRA -->|"therapeutic target"| OXIDATIVE_STRESS
    ESR1["ESR1"]
    RXRA -->|"associated with"| ESR1
    CREBBP["CREBBP"]
    RXRA -->|"associated with"| CREBBP
    PIK3R1["PIK3R1"]
    RXRA -->|"associated with"| PIK3R1
    SRC["SRC"]
    SRC -->|"interacts with"| RXRA
    IGF1R["IGF1R"]
    IGF1R -->|"associated with"| RXRA
    PI3K["PI3K"]
    PI3K -->|"therapeutic target"| RXRA
    AKT["AKT"]
    AKT -->|"interacts with"| RXRA
    AKT1["AKT1"]
    AKT1 -->|"associated with"| RXRA
    EGFR["EGFR"]
    EGFR -->|"associated with"| RXRA
    PIK3CA["PIK3CA"]
    PIK3CA -->|"interacts with"| RXRA
    PPP2CA["PPP2CA"]
    PPP2CA -->|"interacts with"| RXRA
    AKT1 -->|"interacts with"| RXRA
    style RXRA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0