Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about riluzole: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Name | riluzole |
| Key Genes/Proteins | ALS, PLIN2, AQP4, TREK-1, BDNF, MAO |
| Related Diseases | Alzheimer's disease |
| Related Pathways | neurotrophin signaling |
Knowledge base pages for this entity
flowchart TD
riluzole["riluzole"]
ALS("ALS")
riluzole -->|"treats"| ALS
riluzole -->|"targets"| ALS
riluzole -->|"associated with"| ALS
PLIN2(["PLIN2"])
riluzole -->|"targets"| PLIN2
Alzheimer_s_disease("Alzheimer's disease")
riluzole -->|"treats"| Alzheimer_s_disease
AQP4(["AQP4"])
riluzole -->|"targets"| AQP4
TREK_1(["TREK-1"])
riluzole -->|"targets"| TREK_1
BDNF(["BDNF"])
riluzole -->|"targets"| BDNF
MAO("MAO")
riluzole -->|"targets"| MAO
neurotrophin_signaling("neurotrophin signaling")
riluzole -->|"modulates"| neurotrophin_signaling
style riluzole fill:#0d47a1,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | targets | gene | 0.80 |
| PLIN2 | targets | gene | 0.55 |
| Alzheimer's disease | treats | disease | 0.55 |
| AQP4 | targets | gene | 0.55 |
| TREK-1 | targets | gene | 0.55 |
| BDNF | targets | gene | 0.55 |
| MAO | targets | gene | 0.55 |
| neurotrophin signaling | modulates | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS | treats | disease | 0.65 |
| NEURONS | activates | cell_type | 0.65 |
| ALS | therapeutic_target | disease | 0.50 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.50 |
| ALZHEIMER | associated_with | disease | 0.50 |
| BRAINSTEM | associated_with | brain_region | 0.50 |
| ASTROCYTE | associated_with | cell_type | 0.50 |
| EDARAVONE | associated_with | drug | 0.45 |
| BARICITINIB | associated_with | drug | 0.45 |
| ARIMOCLOMOL | associated_with | drug | 0.45 |
| GLUTAMATE | associated_with | phenotype | 0.45 |
| MOTOR NEURONS | associated_with | cell_type | 0.45 |
| MEMANTINE | associated_with | drug | 0.45 |
| INTERNEURONS | associated_with | cell_type | 0.45 |
| SPINAL CORD | associated_with | brain_region | 0.45 |
| CEREBELLUM | associated_with | brain_region | 0.45 |
| EDARAVONE | therapeutic_target | drug | 0.35 |
| ALS | associated_with | disease | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||