Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SPINAL CORD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SPINAL CORD is a concept in neurodegeneration research. Key relationships include: co discussed, activates, interacts with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 80 entities in the SciDEX knowledge graph.
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Knowledge base pages for this entity
graph TD
SPINAL_CORD["SPINAL CORD"]
MAP1LC3B["MAP1LC3B"] -->|"expressed in"| SPINAL_CORD
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"expressed in"| SPINAL_CORD
MOTOR_NEURONS["MOTOR NEURONS"] -->|"expressed in"| SPINAL_CORD
NF__B["NF-KappaB"] -->|"expressed in"| SPINAL_CORD
MTDNA["MTDNA"] -->|"expressed in"| SPINAL_CORD
DNA["DNA"] -->|"expressed in"| SPINAL_CORD
IFN["IFN"] -->|"expressed in"| SPINAL_CORD
MITOCHONDRIA["MITOCHONDRIA"] -->|"expressed in"| SPINAL_CORD
CGAS["CGAS"] -->|"expressed in"| SPINAL_CORD
ALS["ALS"] -->|"expressed in"| SPINAL_CORD| Target | Relation | Type | Str |
|---|---|---|---|
| NEUROMYELITIS OPTICA SPECTRUM DISORDER | involved_in | entity | 0.95 |
| ASTROGLIOSIS | regulates | phenotype | 0.70 |
| ASTROGLIOSIS | treats | phenotype | 0.70 |
| PERICYTE | inhibits | cell_type | 0.70 |
| ALS | treats | disease | 0.70 |
| SOD1 | produces | gene | 0.65 |
| NEUROINFLAMMATION | interacts_with | phenotype | 0.65 |
| GAS6 | activates | gene | 0.65 |
| ASTROCYTES | causes | cell_type | 0.65 |
| GAS6 | regulates | gene | 0.65 |
| TDP-43 | expressed_in | gene | 0.65 |
| NEURONS | causes | cell_type | 0.65 |
| STING | biomarker_for | gene | 0.65 |
| AUTOPHAGY | regulates | phenotype | 0.65 |
| ASTROGLIOSIS | inhibits | phenotype | 0.65 |
| APOPTOSIS | inhibits | phenotype | 0.65 |
| MAPK | regulates | gene | 0.65 |
| NEURON | protects_against | cell_type | 0.65 |
| OLIGODENDROCYTES | produces | cell_type | 0.65 |
| T CELL | activates | cell_type | 0.65 |
| SOD1 | regulates | gene | 0.65 |
| BDNF | inhibits | gene | 0.65 |
| BDNF | treats | gene | 0.65 |
| MICROGLIA | causes | cell_type | 0.65 |
| TNF | inhibits | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| TDP-43 | depleted_in | gene | 0.60 |
| TARDBP | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| APOPTOSIS | depleted_in | phenotype | 0.55 |
| PARKINSON'S | associated_with | concept | 0.50 |
| HUNTINGTON'S | associated_with | concept | 0.50 |
| Pain | associated_with | disease | 0.50 |
| Microrna | activates | pathway | 0.50 |
| FOXD3 | activates | concept | 0.50 |
| SPINAL CORD INJURY | interacts_with | concept | 0.50 |
| Microrna | regulates | pathway | 0.50 |
| SPINAL CORD INJURY | regulates | concept | 0.50 |
| FOXD3 | expressed_in | concept | 0.50 |
| AXON | regulates | concept | 0.50 |
| NEURONS | activates | concept | 0.50 |
| SPINAL CORD INJURY | activates | concept | 0.50 |
| NEURONS | expressed_in | concept | 0.50 |
| CEREBROSPINAL FLUID | protects_against | concept | 0.50 |
| Proteins | activates | protein | 0.50 |
| Cortex | expressed_in | brain_region | 0.50 |
| THALAMUS | expressed_in | concept | 0.50 |
| MACROPHAGES | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS | affects | disease | 0.90 |
| ALS | expressed_in | gene | 0.90 |
| RNA | expressed_in | gene | 0.90 |
| neurodegeneration | affects | disease | 0.90 |
| immune-mediated myelopathy | involved_in | disease | 0.90 |
| multiple sclerosis | affects | disease | 0.90 |
| neuroinflammation | affects | disease | 0.90 |
| SYP | expressed_in | protein | 0.90 |
| Gangliosides | expressed_in | compound | 0.90 |
| Dipeptide Repeat Proteins | expressed_in | protein | 0.85 |
| T Cell Infiltration | expressed_in | process | 0.80 |
| Alzheimer's disease | affects | disease | 0.80 |
| Microglia Activation | expressed_in | process | 0.80 |
| unfolded protein response | active_in | pathway | 0.80 |
| Parkinson's disease | affects | disease | 0.80 |
| axon | enriched_in | organelle | 0.80 |
| frontotemporal dementia | affects | disease | 0.80 |
| DNA | expressed_in | gene | 0.80 |
| CHCHD2 | expressed_in | gene | 0.75 |
| spinal muscular atrophy | affects | disease | 0.70 |
| NF-kB signaling | active_in | pathway | 0.70 |
| HYPOTHALAMUS | regulates | brain_region | 0.70 |
| OPTN | expressed_in | gene | 0.70 |
| Huntington's disease | affects | disease | 0.70 |
| OLAPARIB | causes | drug | 0.70 |
| PARP1 | inhibits | gene | 0.70 |
| epilepsy | affects | disease | 0.70 |
| Amyotrophic lateral sclerosis | associated_with | disease | 0.70 |
| neuropathic pain | affects | disease | 0.70 |
| MAP1LC3B | expressed_in | protein | 0.70 |
| TDP-43 | causes | gene | 0.70 |
| PERICYTE | causes | cell_type | 0.70 |
| PERICYTE | activates | cell_type | 0.70 |
| ALS | reduces | disease | 0.65 |
| MOTOR NEURON | reduces | cell_type | 0.65 |
| NEURODEGENERATION | causes | disease | 0.65 |
| CORTEX | accumulates_in | brain_region | 0.65 |
| MOTOR NEURON | expressed_in | cell_type | 0.65 |
| NEURONS | expressed_in | cell_type | 0.65 |
| NEUROPATHY | activates | disease | 0.65 |
| NEUTROPHIL | increases | cell_type | 0.65 |
| MICROGLIA | activates | cell_type | 0.65 |
| NEURONS | reduces | cell_type | 0.65 |
| NEURON | reduces | cell_type | 0.65 |
| CEREBELLUM | accumulates_in | brain_region | 0.65 |
| C9ORF72 | regulates | gene | 0.65 |
| ALS | regulates | disease | 0.65 |
| OPTN | causes | gene | 0.65 |
| CORTEX | expressed_in | brain_region | 0.65 |
| BDNF | activates | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity