concept

SENESCENT CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SENESCENT CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

0Hypotheses

6Analyses

43Outgoing

50Incoming

0Experiments

14Debates

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💡 Concept Info

Name	SENESCENT CELLS
Related Diseases	neurodegenerative disorders

Pathway Diagram

graph TD
    SENESCENT_CELLS["SENESCENT CELLS"]
    SENESCENT_CELLS -->|"upregulates"| Pro_survival_Networks["Pro-survival Networks"]
    SENESCENT_CELLS -->|"develops"| SASP["SASP"]
    SENESCENT_CELLS -->|"inhibits"| Apoptosis["Apoptosis"]
    SENESCENT_CELLS -->|"contributes to"| Age_related_Chronic_Diseases["Age-related Chronic Diseases"]
    SENESCENT_CELLS -->|"inhibits"| Hematopoietic_Stem_Cells["Hematopoietic Stem Cells"]
    SENESCENT_CELLS -->|"target for"| chronic_kidney_disease["chronic kidney disease"]
    SENESCENT_CELLS -->|"promotes"| skin_aging["skin aging"]
    SENESCENT_CELLS -->|"contributes to"| Aging["Aging"]
    Abt263["Abt263"] -->|"targets"| SENESCENT_CELLS
    Senolytics["Senolytics"] -->|"targets"| SENESCENT_CELLS
    Senolytic_Drugs["Senolytic Drugs"] -->|"targets"| SENESCENT_CELLS
    ABT263["ABT263"] -->|"targets"| SENESCENT_CELLS
    Hesc_Exos["Hesc-Exos"] -->|"modulates"| SENESCENT_CELLS
    senescent_cell_anti_apoptotic_["senescent cell anti-apoptotic pathways"] -.prevents.-> SENESCENT_CELLS
    senolytics["senolytics"] -->|"treats"| SENESCENT_CELLS
    Total_Body_Irradiation["Total-Body Irradiation"] -->|"causes"| SENESCENT_CELLS

Outgoing (43)

Target	Relation	Type	Str
Pro-survival Networks	upregulates	pathway	0.95
Healthspan	associated_with	phenotype	0.95
Aging	associated_with	disease	0.95
SASP	develops	phenotype	0.95
Age-related Chronic Diseases	contributes_to	disease	0.90
Apoptosis	inhibits	process	0.90
Inflammatory Cytokines	associated_with	compound	0.90
Hematopoietic Stem Cells	inhibits	cell_type	0.90
chronic kidney disease	therapeutic_target	disease	0.90
skin aging	promotes	phenotype	0.90
Hematopoietic stem cells	impairs	cell_type	0.90
Wound Healing	involved_in	process	0.90
Tumor Suppression	involved_in	process	0.90
Neurofibrillary Tangles	contributes_to	phenotype	0.90
Ventricular Enlargement	contributes_to	phenotype	0.90
Age-Related Diseases	causes	disease	0.90
Neuroinflammatory Responses	promotes	process	0.90
NEURODEGENERATION	associated_with	process	0.90
Neurodegeneration	promotes	process	0.90
Blood-Brain Barrier	associated_with	brain_region	0.90
IL-6	secretes	protein	0.90
CXCL12	secretes	protein	0.90
Age-Related Diseases	contributes_to	disease	0.85
Aging Pathology	causes	disease	0.85
INFLAMMATORY CYTOKINES	associated_with	protein	0.85
Hematopoietic Stem Cells	associated_with	cell_type	0.85
Neural Microenvironment	modulates	mechanism	0.85
aging	promotes	process	0.85
neurodegenerative disorders	implicated_in	disease	0.80
Age-Related Chronic Diseases	contributes_to	disease	0.80
age-related pathologies	causes	phenotype	0.80
Quality Of Life	associated_with	phenotype	0.80
Senescence-Associated Secretory Phenotype	associated_with	process	0.80
brain aging	causes	process	0.80
neurodegeneration	contributes_to	disease	0.80
therapeutic target	therapeutic_target	process	0.75
PD substantia nigra	localized_to	brain_region	0.70
fibrosis	activates	process	0.70
Ad Pathology	causes	gene	0.70
SASP	activates	process	0.70
fibrosis	causes	disease	0.70
Alzheimer's disease	causes	disease	0.70
amyloid-beta deposition	contributes_to	process	0.60

Incoming (61)

Source	Relation	Type	Str
Abt263	targets	drug	0.95
Senolytic Drugs	targets	drug	0.95
Senolytic Therapy	targets	drug	0.95
CDKN1A	expressed_in	gene	0.95
Hesc-Exos	modulates	compound	0.95
Senolytics	targets	drug	0.95
Senolytics	targets	drug	0.95
ABT263	targets	drug	0.95
cell cycle arrest	associated_with	phenotype	0.95
Total-Body Irradiation	associated_with	process	0.91
senolytic strategies	eliminates	therapeutic approach	0.90
senescent cell anti-apoptotic pathways	prevents	pathway	0.90
senolytics	treats	drug	0.90
ABT263	clears	compound	0.90
NAVITOCLAX	inhibits	drug	0.90
37627641	present in	paper	0.90
BCL-2 inhibition	associated_with	phenotype	0.90
Quercetin	targets	compound	0.90
Dasatinib	targets	drug	0.90
Abt263	associated_with	drug	0.90
EFNB1	expressed_in	gene	0.90
EFNB3	expressed_in	gene	0.90
30232451	have a role in	paper	0.90
SERPINE2	expressed_in	gene	0.90
MICROGLIA	involved_in	cell_type	0.90
38596783	generate	paper	0.90
37627641	rarely present in	paper	0.90
37627641	located primarily in	paper	0.90
Transgenic Suicide Gene	targets	mechanism	0.85
Total-Body Irradiation	causes	process	0.85
Venetoclax	targets	drug	0.85
Navitoclax	targets	drug	0.85
Fisetin	targets	compound	0.85
Luteolin	targets	compound	0.85
EFNB1	involved_in	gene	0.85
PIK3CD	involved_in	gene	0.85
BCL2L1	involved_in	gene	0.85
TP53I2	involved_in	gene	0.85
Microglia	involved_in	cell_type	0.85
dasatinib	associated_with	drug	0.85
quercetin	associated_with	compound	0.80
P21	expressed_in	gene	0.80
SENOLYTICS	eliminates	drug	0.80
DASATINIB	targets	drug	0.80
Senotherapies	targets	drug	0.80
NAVITOCLAX	targets	drug	0.80
DASATINIB	targets	drug	0.80
Navitoclax	inhibits	drug	0.70
BCL2L1	regulates	gene	0.70
Fisetin	associated_with	drug	0.70