Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PIK3CD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PI3K catalytic subunit delta gene - primarily immune-expressed with roles in neuroinflammation
| Gene Symbol | PIK3CD |
| Full Name | PIK3CD |
| Aliases | PI3K catalytic subunit delta gene |
| Chromosome | 1p36.22 |
| Protein Type | Gene |
| Function | encodes a protein of 1,048 amino acids with a molecular weight of approximately 110 kDa. |
| Primary Expression | immune cells including T cells, B cells, natural killer cells, mast cells, and macrophages |
| Molecular Weight | 110 kDa |
| Amino Acids | 048 aa |
| Pathways | PI3K |
| NCBI Gene ID | Search NCBI |
| GeneCards | PIK3CD |
| Human Protein Atlas | PIK3CD |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Known Drugs/Compounds | dasatinib |
| Interactions | AKT1, AKT, AND, PI3K, RAGE, INFLAMMATION |
| KG Connections | 65 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
PIK3CD["<b>PIK3CD</b>"]
Inflammation{"Inflammation"}
PIK3CD -->|"expressed in"| Inflammation
Glioblastoma{"Glioblastoma"}
PIK3CD -->|"expressed in"| Glioblastoma
Als{"Als"}
PIK3CD -->|"expressed in"| Als
Cancer{"Cancer"}
PIK3CD -->|"expressed in"| Cancer
Carcinoma{"Carcinoma"}
PIK3CD -->|"expressed in"| Carcinoma
PIK3CD -->|"therapeutic target"| Carcinoma
PIK3CD -->|"therapeutic target"| Cancer
Tumor{"Tumor"}
PIK3CD -->|"therapeutic target"| Tumor
PI3K["PI3K"]
PIK3CD -->|"expressed in"| PI3K
INFLAMMATION["INFLAMMATION"]
PIK3CD -->|"expressed in"| INFLAMMATION
CANCER["CANCER"]
PIK3CD -->|"expressed in"| CANCER
Pi3K(["Pi3K"])
PIK3CD -->|"expressed in"| Pi3K
PIK3CA["PIK3CA"]
PIK3CA -->|"therapeutic target"| PIK3CD
MTOR["MTOR"]
MTOR -->|"therapeutic target"| PIK3CD
style PIK3CD fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Senescent Cells | involved_in | cell_type | 0.85 |
| apoptosis resistance | mediates | process | 0.85 |
| Inflammation | expressed_in | disease | 0.65 |
| Glioblastoma | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Carcinoma | expressed_in | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Atherosclerosis | therapeutic_target | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| PI3K | expressed_in | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| PIK3R3 | therapeutic_target | gene | 0.60 |
| AKT3 | therapeutic_target | gene | 0.60 |
| PIK3CB | therapeutic_target | gene | 0.60 |
| PIK3R1 | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| AKT1 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| EGFR | therapeutic_target | gene | 0.60 |
| INFLAMMATION | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| Pi3K | expressed_in | pathway | 0.60 |
| MIRNAS | therapeutic_target | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| MICRORNAS | therapeutic_target | gene | 0.60 |
| Akt | therapeutic_target | pathway | 0.60 |
| Mtor | therapeutic_target | pathway | 0.60 |
| Pi3K | therapeutic_target | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| Akt | activates | pathway | 0.60 |
| KRAS | therapeutic_target | gene | 0.60 |
| Pi3K | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| dasatinib | targets | drug | 0.75 |
| PIK3CA | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| PIK3R3 | therapeutic_target | gene | 0.60 |
| PIK3CB | therapeutic_target | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| AKT3 | therapeutic_target | gene | 0.60 |
| PIK3R1 | therapeutic_target | gene | 0.60 |
| CD8 | therapeutic_target | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| SRC | therapeutic_target | gene | 0.60 |
| JAK2 | therapeutic_target | gene | 0.60 |
| PIK3CG | therapeutic_target | gene | 0.60 |
| HRAS | therapeutic_target | gene | 0.60 |
| RAGE | activates | gene | 0.60 |
| MICRORNAS | therapeutic_target | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| MIRNAS | therapeutic_target | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| INS | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||