gene

PIK3CD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3CD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections
0Hypotheses
0Analyses
41Outgoing
24Incoming

Summary

PI3K catalytic subunit delta gene - primarily immune-expressed with roles in neuroinflammation

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🧬 Gene Info
Gene SymbolPIK3CD
Full NamePIK3CD
AliasesPI3K catalytic subunit delta gene
Chromosome1p36.22
Protein TypeGene
Functionencodes a protein of 1,048 amino acids with a molecular weight of approximately 110 kDa.
Primary Expressionimmune cells including T cells, B cells, natural killer cells, mast cells, and macrophages
Molecular Weight110 kDa
Amino Acids048 aa
PathwaysPI3K
NCBI Gene IDSearch NCBI
GeneCardsPIK3CD
Human Protein AtlasPIK3CD
Associated DiseasesAlzheimer's disease, Parkinson's disease
Known Drugs/Compoundsdasatinib
InteractionsAKT1, AKT, AND, PI3K, RAGE, INFLAMMATION
KG Connections65 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

PIK3CD Gene

gene · 1070 words

pi3k-akt-signaling

mechanism · 2556 words

Cellular Senescence in Brain Aging and Neurodegeneration

mechanism · 2517 words

PI3K/Akt Signaling in Neurodegeneration

mechanism · 1803 words

PI3K/Akt Signaling in Parkinson's Disease

mechanism · 1674 words

PI3K — Phosphoinositide 3-Kinase

gene · 1532 words

Pathway Diagram

graph TD
    PIK3CD["<b>PIK3CD</b>"]
    Inflammation{"Inflammation"}
    PIK3CD -->|"expressed in"| Inflammation
    Glioblastoma{"Glioblastoma"}
    PIK3CD -->|"expressed in"| Glioblastoma
    Als{"Als"}
    PIK3CD -->|"expressed in"| Als
    Cancer{"Cancer"}
    PIK3CD -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    PIK3CD -->|"expressed in"| Carcinoma
    PIK3CD -->|"therapeutic target"| Carcinoma
    PIK3CD -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    PIK3CD -->|"therapeutic target"| Tumor
    PI3K["PI3K"]
    PIK3CD -->|"expressed in"| PI3K
    INFLAMMATION["INFLAMMATION"]
    PIK3CD -->|"expressed in"| INFLAMMATION
    CANCER["CANCER"]
    PIK3CD -->|"expressed in"| CANCER
    Pi3K(["Pi3K"])
    PIK3CD -->|"expressed in"| Pi3K
    PIK3CA["PIK3CA"]
    PIK3CA -->|"therapeutic target"| PIK3CD
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| PIK3CD
    style PIK3CD fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

TargetRelationTypeStr
Senescent Cellsinvolved_incell_type0.85
apoptosis resistancemediatesprocess0.85
Inflammationexpressed_indisease0.65
Glioblastomaexpressed_indisease0.65
Alsexpressed_indisease0.65

Incoming (24)

SourceRelationTypeStr
dasatinibtargetsdrug0.75
PIK3CAtherapeutic_targetgene0.60
MTORtherapeutic_targetgene0.60
PIK3R3therapeutic_targetgene0.60
PIK3CBtherapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found