concept

FISETIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FISETIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

1Hypotheses

2Analyses

31Outgoing

11Incoming

0Experiments

2Debates

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💡 Concept Info

Name	FISETIN
Key Genes/Proteins	CD28, MTOR, NLRP3, TNF
Related Diseases	AUTOPHAGY, CANCER, INFLAMMATION, MITOPHAGY, NEUROINFLAMMATION
Related Pathways	NLRP3 INFLAMMASOME

Pathway Diagram

graph TD
    FISETIN["FISETIN"]
    FISETIN -->|"targets"| Senescent_Cells["Senescent Cells"]
    FISETIN -->|"modulates"| Cancer_Signaling_Pathways["Cancer Signaling Pathways"]
    FISETIN -->|"inhibits"| MTOR["MTOR"]
    FISETIN -->|"inhibits"| IL_17A["IL-17A"]
    FISETIN -->|"inhibits"| senescent_cells["senescent cells"]
    FISETIN -->|"treats"| Cancer["Cancer"]
    FISETIN -->|"treats"| PSORIASIS["PSORIASIS"]

Outgoing (31)

Target	Relation	Type	Str
Amyloid-beta-induced neurotoxicity	protects_against	process	0.95
SOD1	upregulates	gene	0.90
SYP	upregulates	gene	0.85
ACHE	downregulates	gene	0.85
DLG4	upregulates	gene	0.85
Senescent Cells	targets	cell_type	0.85
MTOR	downregulates	gene	0.80
PRKAA1	upregulates	gene	0.80
Cancer Signaling Pathways	modulates	pathway	0.80
Neuroinflammation	associated_with	process	0.75
senescent cells	inhibits	cell_type	0.70
Senescent Cells	associated_with	cell_type	0.70
SENESCENCE	inhibits	gene	0.70
Cancer	treats	disease	0.70
NLRP3 INFLAMMASOME	inhibits	pathway	0.65
MITOPHAGY	activates	phenotype	0.65
PSORIASIS	treats	disease	0.65
CD28	activates	gene	0.65
MITOPHAGY	treats	phenotype	0.65
MTOR	interacts_with	gene	0.65
PSORIASIS	protects_against	disease	0.65
Breast Cancer	targets	disease	0.60
Inflammatory Disorders	treats	disease	0.60
Lung Cancer	targets	disease	0.60
NLRP3	associated_with	gene	0.45
TNF	associated_with	gene	0.45
PSORIASIS	associated_with	disease	0.45
QUERCETIN	associated_with	drug	0.45
MTOR	associated_with	gene	0.45
INFLAMMATION	associated_with	phenotype	0.45
CANCER	associated_with	disease	0.45

Incoming (11)

Source	Relation	Type	Str
SENESCENCE	associated_with	phenotype	0.50
INFLAMMATION	associated_with	phenotype	0.45
PSORIASIS	associated_with	disease	0.45
AUTOPHAGY	associated_with	phenotype	0.45
QUERCETIN	associated_with	drug	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
MITOPHAGY	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
CD28	associated_with	gene	0.45
CANCER	associated_with	disease	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Fisetin-Based Senomorphic Therapy for Preserving Beneficial	0.000	-	Senescent cell clearance as neurodegener

Mentioning Analyses (2)

Scientific analyses that reference this entity

Comparative epigenetic signatures: DNA methylation age acceleration and histone

neurodegeneration | 2026-04-18 | 7 hypotheses Top: 0.620

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-02 | 7 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Investigate shared DNA methylation age acceleration and histone modification pat

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

Senescent cell clearance as neurodegeneration therapy

closed · Rounds: 4 · Score: 0.95 · 2026-04-02

Related Research

Hypotheses and analyses mentioning FISETIN in their description or question text

No additional research found