Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SLC18A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SLC18A2 encodes VMAT2, the vesicular monoamine transporter essential for dopamine packaging and neuroprotection in Parkinson's disease
| Gene Symbol | SLC18A2 |
| Full Name | Solute Carrier Family 18 Member A2 |
| Chromosome | 10q25.3 |
| Function | encodes a critical protein responsible for packaging dopamine, norepinephrine, epinephrine, serotonin, and histamine into synaptic vesicles for regulated neurotransmission. |
| Molecular Weight | 56 kDa |
| UniProt ID | Q05940 |
| NCBI Gene ID | 6571 |
| Ensembl ID | ENSG00000165646 |
| OMIM | 193001 |
| GeneCards | SLC18A2 |
| Human Protein Atlas | SLC18A2 |
| Oxidative stress reduction | By sequestering dopamine into vesicles, VMAT2 prevents dopamine oxidation by MAO, which would otherwise produce hydrogen peroxide and toxic aldehydes |
| Quantal release | VMAT2 determines the amount of neurotransmitter per vesicle, affecting the precision of synaptic signaling |
| Vesicle pools | VMAT2 maintains both ready-releasable and reserve vesicle pools essential for sustained neurotransmission |
| Schizophrenia | Altered dopamine signaling due to VMAT2 variants may contribute to psychotic symptoms |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Interactions | SLC6A3, Α-Synuclein, ALDH1A1, NEURON, MICROGLIA, ASTROCYTE |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SLC18A2["SLC18A2"]
SLC18A2 -->|"inhibits"| Parkinson["Parkinson"]
SLC18A2 -->|"inhibits"| Als["Als"]
SLC18A2 -->|"inhibits"| Microglia["Microglia"]
SLC18A2 -->|"inhibits"| Dopaminergic["Dopaminergic"]
SLC18A2 -->|"inhibits"| Oligodendrocyte["Oligodendrocyte"]
SLC18A2 -->|"inhibits"| T_Cell["T Cell"]
SLC18A2 -->|"inhibits"| Astrocyte["Astrocyte"]
SLC18A2 -->|"inhibits"| Neuron["Neuron"]
NEURON["NEURON"] -->|"inhibits"| SLC18A2
MICROGLIA["MICROGLIA"] -->|"inhibits"| SLC18A2
ASTROCYTE["ASTROCYTE"] -->|"inhibits"| SLC18A2
PARKINSON["PARKINSON"] -->|"inhibits"| SLC18A2| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Parkinson | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| SLC6A3 | interacts_with | gene | 0.60 |
| Microglia | inhibits | cell_type | 0.60 |
| Dopaminergic | inhibits | cell_type | 0.60 |
| Oligodendrocyte | inhibits | cell_type | 0.60 |
| T Cell | inhibits | cell_type | 0.60 |
| Astrocyte | inhibits | cell_type | 0.60 |
| Neuron | inhibits | cell_type | 0.60 |
| Α-Synuclein | inhibits | protein | 0.60 |
| benchmark_ot_ad_answer_key:SLC18A2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| SLC6A3 | associated_with | gene | 0.60 |
| ALDH1A1 | associated_with | gene | 0.60 |
| DRD2 | targets | gene | 0.60 |
| ALDH1A1 | interacts_with | gene | 0.60 |
| NEURON | inhibits | gene | 0.60 |
| MICROGLIA | inhibits | gene | 0.60 |
| ASTROCYTE | inhibits | gene | 0.60 |
| PARKINSON | inhibits | gene | 0.60 |
| HLA | targets | gene | 0.60 |
| benchmark_ot_ad_answer_key:SLC18A2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||