gene

STXBP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STXBP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections
0Hypotheses
0Analyses
18Outgoing
11Incoming

Summary

STXBP2 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, implicated in. Associated with Als. Connected to 25 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSTXBP2
Full NameSyntaxin Binding Protein 2 (Munc18-2)
AliasesMunc18-2
Chromosome19p13.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionimmune cells:
Molecular Weight66 kDa
Amino Acids593 aa
UniProt IDO00139
NCBI Gene ID9504
Ensembl IDENSG00000178726
OMIM601717
GeneCardsSTXBP2
Human Protein AtlasSTXBP2
Protein Length593 amino acids
Associated DiseasesHemophagocytic Lymphohistiocytosis, Microvillus Inclusion Disease
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: STXBP2 — AlphaFold O00139 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

STXBP2 — Syntaxin Binding Protein 2

gene · 968 words

STX12 - Syntaxin 12

gene · 2493 words

STXBP3 Gene

gene · 2450 words

STXBP5 — Syntaxin Binding Protein 5

gene · 2399 words

FLNA Gene

gene · 1225 words

Munc18-1 Protein

protein · 1100 words

Pathway Diagram

graph TD
    STXBP2["<b>STXBP2</b>"]
    Als{"Als"}
    STXBP2 -->|"biomarker for"| Als
    FLNA["FLNA"]
    STXBP2 -->|"biomarker for"| FLNA
    CTSD["CTSD"]
    STXBP2 -->|"biomarker for"| CTSD
    MIRNAS["MIRNAS"]
    STXBP2 -->|"biomarker for"| MIRNAS
    JUNB["JUNB"]
    STXBP2 -->|"biomarker for"| JUNB
    NFKBIA["NFKBIA"]
    STXBP2 -->|"biomarker for"| NFKBIA
    Apoptosis(["Apoptosis"])
    STXBP2 -->|"biomarker for"| Apoptosis
    Mapk(["Mapk"])
    STXBP2 -->|"biomarker for"| Mapk
    TRAF6["TRAF6"]
    STXBP2 -->|"biomarker for"| TRAF6
    EGR2["EGR2"]
    STXBP2 -->|"biomarker for"| EGR2
    SPI1["SPI1"]
    STXBP2 -->|"biomarker for"| SPI1
    APOPTOSIS["APOPTOSIS"]
    STXBP2 -->|"biomarker for"| APOPTOSIS
    TRAF6 -->|"biomarker for"| STXBP2
    P38["P38"]
    P38 -->|"biomarker for"| STXBP2
    CD4["CD4"]
    CD4 -->|"biomarker for"| STXBP2
    EGR2 -->|"biomarker for"| STXBP2
    TNF["TNF"]
    TNF -->|"biomarker for"| STXBP2
    SPI1 -->|"biomarker for"| STXBP2
    GENES["GENES"]
    GENES -->|"biomarker for"| STXBP2
    FLNA -->|"biomarker for"| STXBP2
    NFKBIA -->|"biomarker for"| STXBP2
    MIRNAS -->|"biomarker for"| STXBP2
    JUNB -->|"biomarker for"| STXBP2
    style STXBP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (18)

TargetRelationTypeStr
Hemophagocytic Lymphohistiocytosisassociated_withdisease0.80
Syntaxin 3bindsprotein0.80
Microvillus Inclusion Diseaseassociated_withdisease0.70
Apical Membraneexpressed_inentity0.70
Vesicle Dockingregulatesbiological_process0.70

Incoming (11)

SourceRelationTypeStr
TRAF6biomarker_forgene0.60
P38biomarker_forgene0.60
CD4biomarker_forgene0.60
EGR2biomarker_forgene0.60
TNFbiomarker_forgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found