Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STXBP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
STXBP2 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, implicated in. Associated with Als. Connected to 25 entities in the SciDEX knowledge graph.
| Gene Symbol | STXBP2 |
| Full Name | Syntaxin Binding Protein 2 (Munc18-2) |
| Aliases | Munc18-2 |
| Chromosome | 19p13.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | immune cells: |
| Molecular Weight | 66 kDa |
| Amino Acids | 593 aa |
| UniProt ID | O00139 |
| NCBI Gene ID | 9504 |
| Ensembl ID | ENSG00000178726 |
| OMIM | 601717 |
| GeneCards | STXBP2 |
| Human Protein Atlas | STXBP2 |
| Protein Length | 593 amino acids |
| Associated Diseases | Hemophagocytic Lymphohistiocytosis, Microvillus Inclusion Disease |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
STXBP2["<b>STXBP2</b>"]
Als{"Als"}
STXBP2 -->|"biomarker for"| Als
FLNA["FLNA"]
STXBP2 -->|"biomarker for"| FLNA
CTSD["CTSD"]
STXBP2 -->|"biomarker for"| CTSD
MIRNAS["MIRNAS"]
STXBP2 -->|"biomarker for"| MIRNAS
JUNB["JUNB"]
STXBP2 -->|"biomarker for"| JUNB
NFKBIA["NFKBIA"]
STXBP2 -->|"biomarker for"| NFKBIA
Apoptosis(["Apoptosis"])
STXBP2 -->|"biomarker for"| Apoptosis
Mapk(["Mapk"])
STXBP2 -->|"biomarker for"| Mapk
TRAF6["TRAF6"]
STXBP2 -->|"biomarker for"| TRAF6
EGR2["EGR2"]
STXBP2 -->|"biomarker for"| EGR2
SPI1["SPI1"]
STXBP2 -->|"biomarker for"| SPI1
APOPTOSIS["APOPTOSIS"]
STXBP2 -->|"biomarker for"| APOPTOSIS
TRAF6 -->|"biomarker for"| STXBP2
P38["P38"]
P38 -->|"biomarker for"| STXBP2
CD4["CD4"]
CD4 -->|"biomarker for"| STXBP2
EGR2 -->|"biomarker for"| STXBP2
TNF["TNF"]
TNF -->|"biomarker for"| STXBP2
SPI1 -->|"biomarker for"| STXBP2
GENES["GENES"]
GENES -->|"biomarker for"| STXBP2
FLNA -->|"biomarker for"| STXBP2
NFKBIA -->|"biomarker for"| STXBP2
MIRNAS -->|"biomarker for"| STXBP2
JUNB -->|"biomarker for"| STXBP2
style STXBP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Hemophagocytic Lymphohistiocytosis | associated_with | disease | 0.80 |
| Syntaxin 3 | binds | protein | 0.80 |
| Microvillus Inclusion Disease | associated_with | disease | 0.70 |
| Apical Membrane | expressed_in | entity | 0.70 |
| Vesicle Docking | regulates | biological_process | 0.70 |
| Als | biomarker_for | disease | 0.65 |
| FLNA | biomarker_for | gene | 0.60 |
| CTSD | biomarker_for | gene | 0.60 |
| JUNB | biomarker_for | gene | 0.60 |
| NFKBIA | biomarker_for | gene | 0.60 |
| TRAF6 | biomarker_for | gene | 0.60 |
| EGR2 | biomarker_for | gene | 0.60 |
| SPI1 | biomarker_for | gene | 0.60 |
| P38 | biomarker_for | gene | 0.60 |
| MIRNAS | biomarker_for | gene | 0.60 |
| Apoptosis | biomarker_for | pathway | 0.60 |
| Mapk | biomarker_for | pathway | 0.60 |
| APOPTOSIS | biomarker_for | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TRAF6 | biomarker_for | gene | 0.60 |
| P38 | biomarker_for | gene | 0.60 |
| CD4 | biomarker_for | gene | 0.60 |
| EGR2 | biomarker_for | gene | 0.60 |
| TNF | biomarker_for | gene | 0.60 |
| SPI1 | biomarker_for | gene | 0.60 |
| FLNA | biomarker_for | gene | 0.60 |
| NFKBIA | biomarker_for | gene | 0.60 |
| JUNB | biomarker_for | gene | 0.60 |
| GENES | biomarker_for | gene | 0.60 |
| MIRNAS | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||