gene

FLNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FLNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections
0Hypotheses
0Analyses
25Outgoing
10Incoming

Summary

FLNA is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, implicated in. Associated with Als. Connected to 23 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolFLNA
Full NameFilamin A
ChromosomeXq28
FunctionFLNA (Filamin A) is a 280 kDa actin-binding protein that serves as a critical scaffold for protein-protein interactions in eukaryotic cells[@stossel2001]
Molecular Weight280 kDa
PathwaysLeading Edge Extension
UniProt ID[P21333](https://www.uniprot.org/uniprot/P21333)
Ensembl IDENSG00000196924
OMIM300017
GeneCardsFLNA
Human Protein AtlasFLNA
N-terminal actin-binding domainBinds to F-actin
24 repeat repeatsEach containing two calponin homology (CH) domains that serve as protein interaction surfaces
C-terminal dimerization domainEnables orthogonal network formation
Associated DiseasesHeterotopic Neurons
InteractionsOPTN, G3BP1, RNA
KG Connections35 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

FLNA Gene

gene · 1225 words

Neuronal Migration

mechanism · 3104 words

simufilam-alzheimers

clinical_trial · 1810 words

Cell Migration

biological_process · 1785 words

FLNC Protein

protein · 1292 words

HNRNPH1 Gene

gene · 1198 words

Pathway Diagram

graph TD
    FLNA["<b>FLNA</b>"]
    Als{"Als"}
    FLNA -->|"biomarker for"| Als
    CTSD["CTSD"]
    FLNA -->|"biomarker for"| CTSD
    MIRNAS["MIRNAS"]
    FLNA -->|"biomarker for"| MIRNAS
    JUNB["JUNB"]
    FLNA -->|"biomarker for"| JUNB
    NFKBIA["NFKBIA"]
    FLNA -->|"biomarker for"| NFKBIA
    Apoptosis(["Apoptosis"])
    FLNA -->|"biomarker for"| Apoptosis
    Mapk(["Mapk"])
    FLNA -->|"biomarker for"| Mapk
    TNF["TNF"]
    FLNA -->|"biomarker for"| TNF
    STXBP2["STXBP2"]
    FLNA -->|"biomarker for"| STXBP2
    TRAF6["TRAF6"]
    FLNA -->|"biomarker for"| TRAF6
    EGR2["EGR2"]
    FLNA -->|"biomarker for"| EGR2
    SPI1["SPI1"]
    FLNA -->|"biomarker for"| SPI1
    TRAF6 -->|"biomarker for"| FLNA
    P38["P38"]
    P38 -->|"biomarker for"| FLNA
    CD4["CD4"]
    CD4 -->|"biomarker for"| FLNA
    EGR2 -->|"biomarker for"| FLNA
    TNF -->|"biomarker for"| FLNA
    SPI1 -->|"biomarker for"| FLNA
    GENES["GENES"]
    GENES -->|"biomarker for"| FLNA
    STXBP2 -->|"biomarker for"| FLNA
    style FLNA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
neuronal migrationregulatesprocess0.90
OPTNinteracts_withgene0.87
Leading Edge Extensioninvolved_inprocess0.85
Heterotopic Neuronscausesphenotype0.80

Incoming (10)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
TRAF6biomarker_forgene0.60
P38biomarker_forgene0.60
CD4biomarker_forgene0.60
EGR2biomarker_forgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found