Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FLNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FLNA is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, implicated in. Associated with Als. Connected to 23 entities in the SciDEX knowledge graph.
| Gene Symbol | FLNA |
| Full Name | Filamin A |
| Chromosome | Xq28 |
| Function | FLNA (Filamin A) is a 280 kDa actin-binding protein that serves as a critical scaffold for protein-protein interactions in eukaryotic cells[@stossel2001] |
| Molecular Weight | 280 kDa |
| Pathways | Leading Edge Extension |
| UniProt ID | [P21333](https://www.uniprot.org/uniprot/P21333) |
| Ensembl ID | ENSG00000196924 |
| OMIM | 300017 |
| GeneCards | FLNA |
| Human Protein Atlas | FLNA |
| N-terminal actin-binding domain | Binds to F-actin |
| 24 repeat repeats | Each containing two calponin homology (CH) domains that serve as protein interaction surfaces |
| C-terminal dimerization domain | Enables orthogonal network formation |
| Associated Diseases | Heterotopic Neurons |
| Interactions | OPTN, G3BP1, RNA |
| KG Connections | 35 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FLNA["<b>FLNA</b>"]
Als{"Als"}
FLNA -->|"biomarker for"| Als
CTSD["CTSD"]
FLNA -->|"biomarker for"| CTSD
MIRNAS["MIRNAS"]
FLNA -->|"biomarker for"| MIRNAS
JUNB["JUNB"]
FLNA -->|"biomarker for"| JUNB
NFKBIA["NFKBIA"]
FLNA -->|"biomarker for"| NFKBIA
Apoptosis(["Apoptosis"])
FLNA -->|"biomarker for"| Apoptosis
Mapk(["Mapk"])
FLNA -->|"biomarker for"| Mapk
TNF["TNF"]
FLNA -->|"biomarker for"| TNF
STXBP2["STXBP2"]
FLNA -->|"biomarker for"| STXBP2
TRAF6["TRAF6"]
FLNA -->|"biomarker for"| TRAF6
EGR2["EGR2"]
FLNA -->|"biomarker for"| EGR2
SPI1["SPI1"]
FLNA -->|"biomarker for"| SPI1
TRAF6 -->|"biomarker for"| FLNA
P38["P38"]
P38 -->|"biomarker for"| FLNA
CD4["CD4"]
CD4 -->|"biomarker for"| FLNA
EGR2 -->|"biomarker for"| FLNA
TNF -->|"biomarker for"| FLNA
SPI1 -->|"biomarker for"| FLNA
GENES["GENES"]
GENES -->|"biomarker for"| FLNA
STXBP2 -->|"biomarker for"| FLNA
style FLNA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| neuronal migration | regulates | process | 0.90 |
| OPTN | interacts_with | gene | 0.87 |
| Leading Edge Extension | involved_in | process | 0.85 |
| Heterotopic Neurons | causes | phenotype | 0.80 |
| Als | biomarker_for | disease | 0.65 |
| CTSD | biomarker_for | gene | 0.60 |
| JUNB | biomarker_for | gene | 0.60 |
| NFKBIA | biomarker_for | gene | 0.60 |
| TNF | biomarker_for | gene | 0.60 |
| STXBP2 | biomarker_for | gene | 0.60 |
| TRAF6 | biomarker_for | gene | 0.60 |
| EGR2 | biomarker_for | gene | 0.60 |
| SPI1 | biomarker_for | gene | 0.60 |
| P38 | biomarker_for | gene | 0.60 |
| G3BP1 | activates | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| G3BP1 | regulates | gene | 0.60 |
| MIRNAS | biomarker_for | gene | 0.60 |
| Apoptosis | biomarker_for | pathway | 0.60 |
| Mapk | biomarker_for | pathway | 0.60 |
| APOPTOSIS | biomarker_for | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:FLNA | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| TRAF6 | biomarker_for | gene | 0.60 |
| P38 | biomarker_for | gene | 0.60 |
| CD4 | biomarker_for | gene | 0.60 |
| EGR2 | biomarker_for | gene | 0.60 |
| TNF | biomarker_for | gene | 0.60 |
| SPI1 | biomarker_for | gene | 0.60 |
| STXBP2 | biomarker_for | gene | 0.60 |
| GENES | biomarker_for | gene | 0.60 |
| benchmark_ot_ad_answer_key:FLNA | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||