gene

JUNB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JUNB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

94Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

Summary

JUNB is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, regulates, activates. Associated with Als, Atherosclerosis, Autoimmune. Connected to 74 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JUNB
Chromosome	19p13.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	35 kDa
Exons	3
Pathways	MAPK, Wnt
Ensembl ID	ENSG00000171223
GeneCards	JUNB
Human Protein Atlas	JUNB
Transactivation domain (N-terminus)	Transcriptional activation
DNA-binding domain (basic region)	Binds TRE elements
Dimerization domain (leucine zipper)	Jun/Fos heterodimerization
Associated Diseases	Atherosclerosis, Diabetes, Ms
Known Drugs/Compounds	pokeweed mitogen
Interactions	TGFB1, JUN, PTGS2, C-FOS, C-JUN, FOS
KG Connections	94 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JUNB["JUNB"] -->|"regulates"| Autoimmune["Autoimmune"]
    JUNB["JUNB"] -->|"activates"| Hepatitis["Hepatitis"]
    JUNB["JUNB"] -->|"regulates"| Ms["Ms"]
    JUNB["JUNB"] -->|"regulates"| Inflammation["Inflammation"]
    JUNB["JUNB"] -->|"activates"| Fibrosis["Fibrosis"]
    JUNB["JUNB"] -->|"activates"| Carcinoma["Carcinoma"]
    pokeweed_mitogen["pokeweed mitogen"] -->|"activates"| JUNB["JUNB"]
    BMAL1["BMAL1"] -->|"regulates"| JUNB["JUNB"]
    ERK["ERK"] -->|"regulates"| JUNB["JUNB"]
    CLOCK["CLOCK"] -->|"regulates"| JUNB["JUNB"]
    style JUNB fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (65)

Target	Relation	Type	Str
M1 Macrophage Activation	associated_with	process	0.90
AKT Signaling Pathway	regulates	pathway	0.85
ERK Signaling Pathway	regulates	pathway	0.85
Hepatocyte Destruction	contributes_to	process	0.75
Inflammation	regulates	disease	0.75
INFLAMMATION	regulates	gene	0.70
Autoimmune	regulates	disease	0.65
Hepatitis	activates	disease	0.65
Ms	regulates	disease	0.65
Fibrosis	activates	disease	0.65
Carcinoma	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Als	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Psoriasis	therapeutic_target	disease	0.65
M1_MACROPHAGE	activates	cell_type	0.64
CLOCK	regulates	gene	0.60
ARNT	regulates	gene	0.60
AKT	regulates	gene	0.60
TGFB1	activates	gene	0.60
NFKBIA	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
STXBP2	biomarker_for	gene	0.60
TRAF6	biomarker_for	gene	0.60
EGR2	biomarker_for	gene	0.60
SPI1	biomarker_for	gene	0.60
P38	biomarker_for	gene	0.60
CTSD	biomarker_for	gene	0.60
JUN	activates	gene	0.60
BMAL1	regulates	gene	0.60
TNF	regulates	gene	0.60
TFRC	associated_with	gene	0.60
TNFRSF1A	regulates	gene	0.60
CX3CR1	regulates	gene	0.60
P62	therapeutic_target	gene	0.60
PTGS2	inhibits	gene	0.60
Circadian Rhythm	regulates	pathway	0.60
Akt	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
Tgf-Β	activates	pathway	0.60
Apoptosis	biomarker_for	pathway	0.60
Mapk	biomarker_for	pathway	0.60
APOPTOSIS	biomarker_for	gene	0.60
C-FOS	activates	gene	0.60
C-JUN	activates	gene	0.60
DIABETES MELLITUS	associated_with	gene	0.60

Incoming (29)

Source	Relation	Type	Str
pokeweed mitogen	activates	drug	0.90
BMAL1	regulates	gene	0.72
CLOCK	regulates	gene	0.60
TRAF6	biomarker_for	gene	0.60
P38	biomarker_for	gene	0.60
CD4	biomarker_for	gene	0.60
EGR2	biomarker_for	gene	0.60
TNF	biomarker_for	gene	0.60
SPI1	biomarker_for	gene	0.60
STXBP2	biomarker_for	gene	0.60
FLNA	biomarker_for	gene	0.60
CTSD	biomarker_for	gene	0.60
AKT	regulates	gene	0.60
ARNT	regulates	gene	0.60
NFKBIA	biomarker_for	gene	0.60
FOS	activates	gene	0.60
SRC	expressed_in	gene	0.60
VEGF	associated_with	gene	0.60
BMAL1	activates	entity	0.60
AKT	activates	entity	0.60
FOS	inhibits	gene	0.60
FOSB	inhibits	gene	0.60
JUN	inhibits	gene	0.60
ERK	regulates	gene	0.60
GENES	biomarker_for	gene	0.60
MIRNAS	biomarker_for	gene	0.60
INFLAMMATION	regulates	gene	0.60
AND	regulates	gene	0.60
IL8	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

JUNB

Understanding Entity Pages

Summary

Wiki Pages (14)

JUNB Gene

ATF3 Protein

Astrocyte Senescence Pathway in Neurodegeneration

Transcription Regulation Pathway

fosb-protein

MAPK8 Gene

JUND Gene - JunD Transcription Factor

FLNA Gene

STXBP2 — Syntaxin Binding Protein 2

FOS Gene

JunB Protein

BMAL1 (ARNTL) Gene