gene

SYNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

28Hypotheses

30Analyses

11Outgoing

8Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	SYNA
Full Name	Synapsin I
Chromosome	17q21.31
Function	is a neuronal phosphoprotein associated with the cytoplasmic surface of synaptic vesicles.
Primary Expression	Brain (cortex, hippocampus, cerebellum), neurons
Subcellular Localization	presynaptic terminals where it associates with the cytoplasmic surface of synaptic vesicles. [@takamori2006]
Amino Acids	706 aa
UniProt ID	P17600
NCBI Gene ID	6853
Ensembl ID	ENSG00000135547
OMIM	313440
GeneCards	SYNA
Human Protein Atlas	SYNA
KG Connections	19 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SYNA — AlphaFold P17600 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["SYNA"]
    N1["TFEB"]
    N1 -->|"binds to"| N0
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 protein

Outgoing (11)

Target	Relation	Type	Str
SPP1	co_discussed	gene	0.40
DYSF	co_discussed	gene	0.40
C1QA	co_discussed	gene	0.40
GRN	co_discussed	gene	0.40
CTSB	co_discussed	gene	0.40
ALZHEIMER'S DISEASE	co_discussed	gene	0.40
PHAGOCYTOSIS	co_discussed	process	0.40
COMPLEMENT	co_discussed	pathway	0.40
LATE	co_discussed	disease	0.40
AMYLOID	co_discussed	gene	0.40
ANXIETY	co_discussed	gene	0.40

Incoming (8)

Source	Relation	Type	Str
TFEB	binds_to	protein	0.90
GNAL	co_discussed	gene	0.40
COMPLEMENT CASCADE	co_discussed	pathway	0.40
C1Q	co_discussed	gene	0.40
MICROGLIA	co_discussed	cell_type	0.40
NEUROINFLAMMATION	co_discussed	process	0.40
RNA	co_discussed	gene	0.40
NEUROINFLAMMATORY	co_discussed	pathway	0.40

Targeting Hypotheses (28)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95	0.695	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.677	Alzheimer's disease	Circuit-level neural dynamics in neurode
SASP-Driven Microglial Metabolic Reprogramming in Synaptic P	0.638	neurodegeneration	Senolytic therapy for age-related neurod
Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.614	Alzheimer's disease	Circuit-level neural dynamics in neurode

H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from	0.588	neurodegeneration	How does APOE4's beneficial immune funct
MEF2C-Dependent Synaptic Gene Regulation	0.578	neurodegeneration	What molecular mechanisms mediate HDAC9'
SASP-Mediated Cholinergic Synapse Disruption	0.564	neurodegeneration	Senolytic therapy for age-related neurod
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S	0.548	cell biology	What is the relative contribution of con
Neutral Sphingomyelinase-2 Inhibition for Synaptic Protectio	0.546	neurodegeneration	Lipid raft composition changes in synapt
TREM2 Agonism to Redirect Microglia from Synaptic Pruning to	0.521	neurodegeneration	How do ALS-associated OPTN mutations mec
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.520	neurodegeneration	How do the seven novel ALS genes functio
Sleep Spindle-Synaptic Plasticity Enhancement	0.491	neurodegeneration	Sleep disruption as cause and consequenc
Perforant Path Presynaptic Terminal Protection Strategy	0.484	neurodegeneration	Selective vulnerability of entorhinal co
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu	0.470	neurodegeneration	Gene expression changes in aging mouse b
Multi-Target Synergy via Presynaptic Vesicle Hub Convergence	0.467	neurodegeneration	What molecular mechanisms underlie Atrem
Synaptic Pruning Precision Therapy	0.465	Alzheimer's disease	Neuroinflammation and microglial priming
C1q Inhibition Prevents Synaptic Mitochondrial Dysfunction v	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica
Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto	0.454	neurodegeneration	Cell type vulnerability in Alzheimer's D
Complement Cascade Activation Bridges Microglial OxPC Sensin	0.452	neuroinflammation	What molecular mechanisms enable microgl
CaMKII-Dependent Synaptic Circuit Amplification	0.444	neuroscience	Circuit-level neural dynamics in neurode
APOE-Mediated Synaptic Lipid Raft Stabilization	0.426	neurodegeneration	Mechanistic role of APOE in neurodegener
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics	0.424	neurodegeneration	Synaptic pruning by microglia in early A
TREM2 Conformational Stabilizers for Synaptic Discrimination	0.411	neurodegeneration	Synaptic pruning by microglia in early A
Complement-Mediated Synaptic Protection	0.410	neurodegeneration	Neuroinflammation and microglial priming
Complement-Mediated Synaptic Pruning Dysregulation	0.398	neurodegeneration	Gene expression changes in aging mouse b
Synaptic Vesicle Tau Capture Inhibition	0.340	Alzheimer's Disease	Tau propagation mechanisms and therapeut
Trans-Synaptic Adhesion Molecule Modulation	0.340	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (30)

Scientific analyses that reference this entity

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Clinical, Immunological, and Vesicular Markers in Sarcopenia and Presarcopenia. [PMID:40917056]	Shuliko LM, Svarovsky DA, Spirina LV, Og	Front Biosci (Landmark Ed)	2025	1
CD47-blocking antibody interferes with neutrophil extracellular traps formation [PMID:39951937]	Diao Y, Hao M, Xie M, Hu X, Tan R, Wang	J Neuroimmunol	2025	1
Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Indu [PMID:40116141]	Xie G, Jiang G, Huang L, Sun S, Li X, Wu	CNS Neurosci Ther	2025	1
Enhanced anticancer activity of nanoemulsified cardamom extract via modulation o [PMID:41658858]	["Soltani T", "Karimian M", "Vaziri H",	Biochemistry and biophysics re	2026	0
Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular [PMID:41850064]	["Wang H", "Liu Y", "Jiang K", "Yin J",	Poultry science	2026	0
Fragment merging design, synthesis, and biological evaluation of novel methyl Se [PMID:41785527]	["Shaaban S", "Hawas S", "Elmaaty A", "B	Bioorganic & medicinal chemist	2026	0
Theranekron modulates extracellular matrix and apoptotic signaling pathways in c [PMID:41852375]	["Kuccukturk S", "Duran T", "Vanli S", "	Cytotechnology	2026	0
Saliva liquid biopsy: MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers i [PMID:41779471]	["Cruz-Romero S", "Baldi\u00f3n A", "Taw	Journal of applied oral scienc	2026	0
Glomerular Transcriptome Analysis Reveals Endothelial Disturbances in Patients W [PMID:41659822]	["Nelson-Taylor S", "Troost J", "Giannin	Kidney medicine	2026	0
Encapsulation of hydroxyurea in exosomes derived from adipose mesenchymal stem c [PMID:41702234]	["Taheri Kangarshahi Z", "Ganji S", "Ash	Translational oncology	2026	0
NSUN2 promoted tumor growth and metastatic via m [PMID:41794778]	["Li R", "Jin D", "Shao S", "Guo J"]	Cell death & disease	2026	0
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026	0
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026	0
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026	0
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026	0
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026	0
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026	0
Zhi-Gan Formula improved insomnia and anxiety comorbidity in a mouse model via P [PMID:41525914]	Liu R, Wu Z, Yin Y, Song C, Zhang C et a	J Ethnopharmacol	2026	0
Triterpenoid saponins from Platycodon grandiflorus exhibit antidepressant-like e [PMID:41539634]	Yoon S, Chun E, Iqbal H, Kim SH, Kim SY	J Ethnopharmacol	2026	0
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026	0

SYNA

Understanding Entity Pages

Wiki Pages (9)

SYNA — Synapsin I

GSK-3β

Climbing Fiber Synapses

PACAP/VPAC Receptor Neurons

CFOS Gene

Parallel Fiber Synapses

NLGN2 Protein

Synaptotagmin-3 Protein

Genes

Pathway Diagram

Outgoing (11)

Incoming (8)

Targeting Hypotheses (28)

Mentioning Analyses (30)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

How do P/Q channel deficits paradoxically increase thalamic excitability despite

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

Extracellular vesicle biomarkers for early AD detection

Is C1q elevation in AD pathogenic or compensatory for amyloid clearance?

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

Which tau propagation mechanism predominates in different brain regions and dise

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

How do perivascular cells specifically recognize and respond to amyloid-β to upr

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

Trans-synaptic tau spreading and propagation mechanisms in AD

Neuroinflammation and microglial priming in early Alzheimer's Disease

Tau propagation mechanisms and therapeutic interception points

Quantitative proteomics of the aging synapse in early Alzheimer disease

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Tau propagation mechanisms and therapeutic interception points

Synaptic pruning by microglia in neurodegeneration

Extracellular vesicle biomarkers for early AD detection

Tau propagation mechanisms and therapeutic interception points

Tau propagation mechanisms and therapeutic interception points

Synaptic pruning by microglia in early AD

Related Papers (20)