gene

DYSF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYSF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

17Hypotheses

23Analyses

47Outgoing

50Incoming

Summary

Comprehensive review of DYSF gene, encoding dysferlin, a critical membrane repair protein with roles in muscular dystrophy and potential implications for neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	DYSF
Full Name	Dysferlin
Chromosome	2p13.2
Function	is a human gene located on chromosome 2p13.
Primary Expression	Skeletal muscle, Cardiac muscle, Brain, Spinal cord
Molecular Weight	~237 kDa
Amino Acids	080 aa
Pathways	Exocytosis, Immune Response
UniProt ID	O75923
NCBI Gene ID	8291
Ensembl ID	ENSG00000131721
OMIM	603009
GeneCards	DYSF
Human Protein Atlas	DYSF
Protein Length	2,080 amino acids
Associated Diseases	Ms
KG Connections	112 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DYSF — AlphaFold O75923 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DYSF["<b>DYSF</b>"]
    Ms{"Ms"}
    DYSF -->|"associated with"| Ms
    ANXA2["ANXA2"]
    DYSF -->|"associated with"| ANXA2
    Exocytosis(["Exocytosis"])
    DYSF -->|"regulates"| Exocytosis
    Immune_Response(["Immune Response"])
    DYSF -->|"regulates"| Immune_Response
    neurodegeneration["neurodegeneration"]
    DYSF -->|"implicated in"| neurodegeneration
    LMNA["LMNA"]
    LMNA -->|"associated with"| DYSF
    ANXA1["ANXA1"]
    ANXA1 -->|"associated with"| DYSF
    style DYSF fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

Target	Relation	Type	Str
plasma membrane repair	involved_in	process	0.85
Ms	associated_with	disease	0.65
ANXA2	associated_with	gene	0.60
Exocytosis	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
CARDIOVASCULAR	co_discussed	disease	0.40
INFECTION	co_discussed	disease	0.40
MUL1	co_discussed	gene	0.40
NBR1	co_discussed	gene	0.40
NLRP3	co_discussed	protein	0.40
FMR1	co_discussed	gene	0.40
OPTN	co_discussed	gene	0.40
OPTINEURIN	co_discussed	protein	0.40
PARL	co_discussed	protein	0.40
PEX3	co_discussed	gene	0.40
PINK1	co_discussed	gene	0.40
PTEN	co_discussed	gene	0.40
PRKN	co_discussed	gene	0.40
PARKIN	co_discussed	gene	0.40
RB1CC1	co_discussed	gene	0.40
FIP200	co_discussed	gene	0.40
RB1	co_discussed	protein	0.40
FAM134B	co_discussed	gene	0.40
RHOT1	co_discussed	gene	0.40
MIRO1	co_discussed	protein	0.40
RIPK3	co_discussed	gene	0.40
RTN3	co_discussed	gene	0.40
SESN2	co_discussed	gene	0.40
SNCA	co_discussed	gene	0.40
SNCAIP	co_discussed	gene	0.40
SQSTM1	co_discussed	gene	0.40
P62	co_discussed	protein	0.40
STING1	co_discussed	protein	0.40
TAX1BP1	co_discussed	gene	0.40
MICROGLIA	co_discussed	cell_type	0.40
PHAGOCYTOSIS	co_discussed	process	0.40
COMPLEMENT	co_discussed	pathway	0.40
ANXIETY	co_discussed	gene	0.40
ALS	co_discussed	disease	0.40
NEURODEGENERATIVE DISEASES	co_discussed	disease	0.40
NLR	co_discussed	gene	0.40
PARKINSON	co_discussed	gene	0.40
PRESENILIN	co_discussed	protein	0.40
RAS	co_discussed	protein	0.40
REACTIVE OXYGEN SPECIES	co_discussed	process	0.40
INTERFERON	co_discussed	protein	0.40

Incoming (65)

Source	Relation	Type	Str
LMNA	associated_with	gene	0.60
ANXA1	associated_with	gene	0.60
SYNA	co_discussed	gene	0.40
ABCD3	co_discussed	gene	0.40
MYOT	co_discussed	gene	0.40
AMBRA1	co_discussed	protein	0.40
UBIQUITIN	co_discussed	protein	0.40
RELA	co_discussed	gene	0.40
ATM	co_discussed	protein	0.40
BCL2	co_discussed	gene	0.40
BCL2L11	co_discussed	gene	0.40
BCL2L13	co_discussed	gene	0.40
BECN1	co_discussed	gene	0.40
BNIP3	co_discussed	gene	0.40
BNIP3L	co_discussed	protein	0.40
CALCOCO2	co_discussed	gene	0.40
NDP52	co_discussed	gene	0.40
CANX	co_discussed	gene	0.40
CAT	co_discussed	gene	0.40
CTSD	co_discussed	gene	0.40
HEPSIN	co_discussed	protein	0.40
DDIT3	co_discussed	gene	0.40
CHOP	co_discussed	gene	0.40
DISC1	co_discussed	gene	0.40
DNM1L	co_discussed	gene	0.40
DRP1	co_discussed	protein	0.40
EIF2AK3	co_discussed	gene	0.40
PERK	co_discussed	protein	0.40
EIF2S1	co_discussed	gene	0.40
EMD	co_discussed	gene	0.40
EPAS1	co_discussed	gene	0.40
ERN1	co_discussed	gene	0.40
IRE1	co_discussed	protein	0.40
GNAL	co_discussed	gene	0.40
FUNDC1	co_discussed	gene	0.40
G3BP1	co_discussed	gene	0.40
GBA	co_discussed	gene	0.40
HIF1A	co_discussed	protein	0.40
LGALS3	co_discussed	gene	0.40
LC3	co_discussed	protein	0.40
LMNA	co_discussed	gene	0.40
MAPK8	co_discussed	gene	0.40
JNK	co_discussed	protein	0.40
MAP1LC3B	co_discussed	gene	0.40
MFN1	co_discussed	gene	0.40
ALZHEIMER'S DISEASE	co_discussed	gene	0.40
NEUROINFLAMMATION	co_discussed	process	0.40
NF-ΚB	co_discussed	pathway	0.40
NEURON	co_discussed	gene	0.40
AUTOPHAGY	co_discussed	process	0.40

Targeting Hypotheses (17)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop optogenetic targeting PV interneurons to restore	0.633	Alzheimer's disease	Circuit-level neural dynamics in neurode
Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbate	0.610	-	Do β-amyloid plaques and neurofibrillary
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.569	neurodegeneration	What is the molecular mechanism by which
Glymphatic-Mediated Tau Clearance Dysfunction	0.546	neuroscience	Circuit-level neural dynamics in neurode
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated

C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by	0.537	neurodegeneration	How does PIKFYVE inhibition activate unc
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Sign	0.533	neuroscience	Circuit-level neural dynamics in neurode
TREM2-Mediated Microglial Dysfunction Disrupts Perivascular	0.527	neuroscience	Circuit-level neural dynamics in neurode
BACE1/NRG1 Axis Dysfunction Drives Excitatory/Inhibitory Imb	0.527	neurodegeneration	What are the physiological functions of
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.509	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
CRISPR-Mediated Mitochondrial Genome Editing for Complex I D	0.491	neurodegeneration	CRISPR-based therapeutic approaches for
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Rece	0.489	neuroscience	Circuit-level neural dynamics in neurode
C1q Inhibition Prevents Synaptic Mitochondrial Dysfunction v	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica
TREM2-Mediated Microglial Dysfunction Disrupts Oligodendrocy	0.452	neuroscience	Circuit-level neural dynamics in neurode
Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Sign	0.434	neuroscience	Circuit-level neural dynamics in neurode
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction	0.398	neurodegeneration	Metabolic reprogramming in neurodegenera
Brain Insulin Resistance with Glucose Transporter Dysfunctio	0.398	neurodegeneration	Metabolic reprogramming in neurodegenera

Mentioning Analyses (23)

Scientific analyses that reference this entity

Are interneuron oscillation deficits compensatory responses or primary pathologi

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557

What are the specific circulating factors in exercise-conditioned plasma that me

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589

What signals trigger microglia to specifically recognize and phagocytose LC axon

neuroinflammation | 2026-04-14 | 0 hypotheses

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.614

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730]	Zhang Y, Jiang H, Zhang F, Liao J	Neural regeneration research	2026
The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859]	Qi L, Yi J, Shen Y, Jiang H, Yao X et al	Biochem Pharmacol	2026
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004]	Zhang H, Xiao J, Yi Y, Chen B, Lv W et a	Phytomedicine	2026
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005]	You T, Dai B, Ding X, He Z, Peng J et al	Phytomedicine	2026
AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996]	Zhang HH, Zhang ZL, Xu W	Reproduction	2026
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026
FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672]	Jiang F, Huang H, Dong Z, Zhang L, Zhang	Cell Death Discov	2026
Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824]	Zhang T, Hu L, Chen D, Chen Y, Zhou F et	Nat Commun	2026
α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317]	Wu C, Jiang J, Qiu H, Xie J, Li S	Fish Shellfish Immunol	2026
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899]	Fang Y, Deng M, Huang K, Song H, Chu Y,	Cell communication and signali	2026
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653]	Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y	Journal of diabetes	2026
Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101]	Cheng YL, Su MS, Liao CC, Chang TW, Hsie	Journal of microbiology, immun	2026
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436]	Shan C, Szili-Torok T, Yue G, Zhang L, M	Phytomedicine : international	2026
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550]	["Gao L", "Shen J", "Gao J", "Li T", "Ya	Antioxidants (Basel, Switzerla	2026
Plasma pTau 217/β-amyloid 1-42 ratio for enhanced accuracy and reduced uncertain [PMID:41562409]	Benina N, Buitrago L, De Simone FI, Radw	Brain	2026
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026
Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627]	El-Mahrouk SR, El-Kadi AOS	Archives of toxicology	2025
Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796]	Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu	Journal of neuroinflammation	2025
Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261]	Yang R, Meng X, Zhao W, Xu SQ, Wang SY,	Bioorganic chemistry	2025
Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458]	Pradeepkiran JA, Kshirsagar S, Alvir RV,	Biochimica et biophysica acta.	2025

DYSF

Understanding Entity Pages

Summary

Wiki Pages (14)

DYSF — Dysferlin

CLCN1 (Chloride Voltage-Gated Channel 1)

Alsin Protein

SYNA — Synapsin I

Parabrachial Nucleus (PBN) Neurons

CHCHD10 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10

Pathway Diagram

Outgoing (47)

Incoming (65)

Targeting Hypotheses (17)

Mentioning Analyses (23)

Are interneuron oscillation deficits compensatory responses or primary pathologi

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What are the specific circulating factors in exercise-conditioned plasma that me

What signals trigger microglia to specifically recognize and phagocytose LC axon

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

What is the high-resolution structure of the APOE4 hinge region and its role in

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do transferred mitochondria from diseased astrocytes carry pathological damage t

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Do circadian disruptions cause neurodegeneration or result from it?

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

What determines the specificity of RNA-protein interactions that drive distinct

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Lipid raft composition changes in synaptic neurodegeneration

Related Papers (20)

DYSF

Understanding Entity Pages

Summary

Wiki Pages (14)

DYSF — Dysferlin

CLCN1 (Chloride Voltage-Gated Channel 1)

Alsin Protein

SYNA — Synapsin I

Parabrachial Nucleus (PBN) Neurons

CHCHD10 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10

Nucleus Raphe Pallidus Expanded

Pinealocytes

Cerebellar Unipolar Brush Cells in Episodic Ataxia

Spinal Cord Interneurons in Motor Neuron Disease

CCDC88A — Coiled-Coil Domain Containing 88A

Wide Dynamic Range (WDR) Neurons

CHCHD3 — Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3

Genes

Pathway Diagram

Outgoing (47)

Incoming (65)

Targeting Hypotheses (17)

Mentioning Analyses (23)

Are interneuron oscillation deficits compensatory responses or primary pathologi

Why does autophagy inhibition improve neuronal survival when autophagy is typica

What are the specific circulating factors in exercise-conditioned plasma that me

What signals trigger microglia to specifically recognize and phagocytose LC axon

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

What is the high-resolution structure of the APOE4 hinge region and its role in

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

Do transferred mitochondria from diseased astrocytes carry pathological damage t

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Do circadian disruptions cause neurodegeneration or result from it?

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

What determines the selectivity of complement-mediated synaptic elimination in p

What determines the specificity of RNA-protein interactions that drive distinct

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Autophagy-lysosome pathway convergence across neurodegenerative diseases

Lipid raft composition changes in synaptic neurodegeneration

Related Papers (20)