Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEUROINFLAMMATORY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NEUROINFLAMMATORY |
| Key Genes/Proteins | C1Q, SYNA |
| Related Pathways | COMPLEMENT |
| Linked Hypotheses | 7 hypotheses |
Knowledge base pages for this entity
graph TD
NEUROINFLAMMATORY["NEUROINFLAMMATORY"]
P2RY12["P2RY12"] -.biomarker for.-> NEUROINFLAMMATORY
TMEM119["TMEM119"] -.biomarker for.-> NEUROINFLAMMATORY
GAIN["GAIN"] -.biomarker for.-> NEUROINFLAMMATORY
TREM2["TREM2"] -.biomarker for.-> NEUROINFLAMMATORY
NEUROINFLAMMATION["NEUROINFLAMMATION"] -.biomarker for.-> NEUROINFLAMMATORY
PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| NEUROINFLAMMATORY
COMPLEMENT["COMPLEMENT"] -->|"inhibits"| NEUROINFLAMMATORY
NF__B["NF-KappaB"] -->|"activates"| NEUROINFLAMMATORY
C1Q["C1Q"] -->|"inhibits"| NEUROINFLAMMATORY
ANXIETY["ANXIETY"] -->|"activates"| NEUROINFLAMMATORY| Target | Relation | Type | Str |
|---|---|---|---|
| C1Q | co_discussed | gene | 0.40 |
| COMPLEMENT | co_discussed | pathway | 0.40 |
| SYNA | co_discussed | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| P2RY12 | biomarker_for | gene | 0.60 |
| TMEM119 | biomarker_for | gene | 0.60 |
| GAIN | biomarker_for | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| TREM2 | biomarker_for | gene | 0.60 |
| NEUROINFLAMMATION | biomarker_for | gene | 0.60 |
| PHAGOCYTOSIS | activates | gene | 0.60 |
| COMPLEMENT | inhibits | gene | 0.60 |
| NF-ΚB | activates | gene | 0.60 |
| C1Q | inhibits | gene | 0.60 |
| ANXIETY | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| C1QA | activates | gene | 0.60 |
| NEUROTOXICITY | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| MITOCHONDRIAL DNA | activates | gene | 0.60 |
| MOTOR NEURONS | activates | gene | 0.60 |
| NF-ΚB | associated_with | gene | 0.60 |
| MTDNA | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| IFN | associated_with | gene | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
| CGAS | activates | gene | 0.60 |
| ALS | associated_with | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| HK2 | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| ALS | activates | gene | 0.60 |
| FLAVONOIDS | regulates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | activates | gene | 0.60 |
| CRY | regulates | gene | 0.60 |
| BMAL1 | regulates | gene | 0.60 |
| OXIDATIVE STRESS | regulates | gene | 0.60 |
| CLOCK | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| PER | regulates | gene | 0.60 |
| NEUROINFLAMMATION | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 0.60 |
| TFR1 | causes | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam | 0.617 | neurodegeneration | What are the mechanisms by which gut mic |
| GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R | 0.498 | neuroinflammation | Why do TAM receptors protect against neu |
| Cardiovascular-Neuroinflammatory Dual Targeting | 0.462 | neurodegeneration | Neuroinflammation and microglial priming |
| TREM2 Antagonism in Late-Stage Tauopathy — Reducing Neuroinf | 0.444 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
| Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro | 0.424 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632
neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| Decoding cell death signals in liver inflammation. [PMID:23567086] | Brenner C, Galluzzi L, Kepp O, Kroemer G | J Hepatol | 2013 | 1 |
| Benzo[a]pyrene promotes gastric cancer progression via activation of the Correa [PMID:41780474] | Tong J, Liu S, Du T, Liu W, Jin Z et al. | Ecotoxicol Environ Saf | 2026 | 0 |
| Wnt-dependent modulation of alveolar epithelial phenotypes and barrier function [PMID:41678947] | Lin YC, Igarashi M, Sakai Y, Nishikawa M | Biochem Biophys Res Commun | 2026 | 0 |
| Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PK [PMID:40659086] | Li Z, Tan D, Lin J, Zhang T, Liu B et al | J Adv Res | 2026 | 0 |
| Celastrol treatment attenuates the inflammatory response in Alzheimer's disease [PMID:40762111] | Cao F, Zhang P, Zheng Z, Wang P, Wang Y | Neurol Res | 2026 | 0 |
| CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis [PMID:41519399] | Zhang Y, Wang J, Song Y, Chai J, Li L et | Biochem Pharmacol | 2026 | 0 |
| Panax ginseng-derived Exosome-like Nanoparticles Prevent LPS-induced Septic Shoc [PMID:41530048] | Kim Y, Kim YK, Lee S, Kim M, Lee SW et a | Mol Pharm | 2026 | 0 |
| Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosi [PMID:41702081] | Qin H, Yang L, Du J, Xu X, Chen Z et al. | Int Immunopharmacol | 2026 | 0 |
| 2'-Fucosyllactose Alleviates Metabolic Hypertension in Mice via Gut Microbiota M [PMID:41926238] | Chen J, Liang S, Liu D, Yang S, Yan Q et | J Agric Food Chem | 2026 | 0 |
| Leveraging intraperitoneal delivery of toll-like receptor agonists to treat peri [PMID:41926324] | Yan H, Chia D, Ernst S, Demuytere J, Cos | Expert Opin Drug Deliv | 2026 | 0 |
| Small-molecule PCSK9 inhibition enhances BBB amyloid-β clearance and suppresses [PMID:41927877] | Miao J, Wang J, Zhou W, Guo J | Sci Rep | 2026 | 0 |
| Anti-carbamylated protein antibodies stabilize carbamylated Histone H3 to promot [PMID:41930627] | Nakabo S, Hanata N, Patino-Martinez E, H | Arthritis Rheumatol | 2026 | 0 |
| In silico design of a novel multi-epitope mRNA vaccine candidate for BtHKU5-CoV- [PMID:41931545] | Zheng N, Xu Y | PLoS Negl Trop Dis | 2026 | 0 |
| Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF. [PMID:41931597] | Ma B, Lyu W, Rizk J, Han X, Kjær M et al | Sci Immunol | 2026 | 0 |
| Reverse vaccinology and immunoinformatics Approaches Driven designing of a Novel [PMID:41934706] | Siddiquee NH, Al Mamun MA, Dremit TI, Ul | Hum Immunol | 2026 | 0 |
| MEX3B aggravates osteoarthritis progression by post-transcriptionally activating [PMID:41935341] | Fu Z, Huang Y, Zhang S, Chen J | J Orthop Surg Res | 2026 | 0 |
| Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876] | Chen F, Xue Y, Ma X, Chen L, Shao Z et a | Adv Sci (Weinh) | 2026 | 0 |
| Molecular characterization and immunoinformatics-based design of a multi-epitope [PMID:41949632] | Asim M, Makki HH | Antonie Van Leeuwenhoek | 2026 | 0 |
| Zearalenone causes female reproductive lipotoxicity through the ERα-CD36/TLR4 si [PMID:41957128] | Dai C, Fu W, Huang Y, Li T, Ma Z et al. | Commun Biol | 2026 | 0 |