Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNGAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SYNGAP1 |
| Full Name | Synaptic Ras GTPase Activating Protein 1 |
| Chromosome | 6p21.3 |
| Function | is a major postsynaptic density (PSD) protein that regulates Ras signaling and controls AMPA receptor trafficking, making it essential for synaptic plasticity, learning, and memory. |
| Primary Expression | Brain (cortex, hippocampus), postsynaptic densities |
| Molecular Weight | 150 kDa |
| Amino Acids | 1343 aa |
| UniProt ID | [Q9ULB0](https://www.uniprot.org/uniprot/Q9ULB0) |
| Ensembl ID | ENSG00000197283 |
| OMIM | 603384 |
| GeneCards | SYNGAP1 |
| Human Protein Atlas | SYNGAP1 |
| N-terminal domain | Contains a C2 domain (Ca²⁺/lipid-binding) |
| PDZ-binding motif | Mediates interaction with PSD-95 and other scaffolding proteins |
| SH3 domain | Protein-protein interactions |
| Associated Diseases | neurodegeneration |
| Interactions | ERK, STXBP1, RAS |
| SciDEX Hypotheses | Interneuron SYNGAP1 Deficiency Disrupts Cortical C |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SYNGAP1["<b>SYNGAP1</b>"]
Aging{"Aging"}
SYNGAP1 -->|"therapeutic target"| Aging
Als{"Als"}
SYNGAP1 -->|"therapeutic target"| Als
Ms{"Ms"}
SYNGAP1 -->|"therapeutic target"| Ms
ERK["ERK"]
SYNGAP1 -->|"inhibits"| ERK
Epigenetic(["Epigenetic"])
SYNGAP1 -->|"therapeutic target"| Epigenetic
neurodegeneration["neurodegeneration"]
SYNGAP1 -->|"implicated in"| neurodegeneration
SCN1A["SCN1A"]
SCN1A -->|"therapeutic target"| SYNGAP1
STXBP1["STXBP1"]
STXBP1 -->|"inhibits"| SYNGAP1
ERK -->|"inhibits"| SYNGAP1
RAS["RAS"]
RAS -->|"inhibits"| SYNGAP1
AND["AND"]
AND -->|"inhibits"| SYNGAP1
style SYNGAP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| ERK | inhibits | gene | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Chaperone | inhibits | pathway | 0.60 |
| autism spectrum disorder | activates | disease | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| cortex | expressed_in | brain_region | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| neurodevelopment | promoted: Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During Development | disease | 0.58 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass | 0.576 | neurodevelopment | How does SYNGAP1, a 'synaptic' protein, |
Scientific analyses that reference this entity
neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||