TRPM8

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPM8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TRPM8 is a protein involved in neurodegeneration research. Key relationships include: expressed in, upregulates, implicated in. Associated with ALS, Als, Inflammation. Connected to 20 entities in the SciDEX knowledge graph.

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graph TD
    TRPM8["<b>TRPM8</b>"]
    Periodontal_Ligament_Cells["Periodontal Ligament Cells"]
    TRPM8 -->|"expressed in"| Periodontal_Ligament_Cells
    Als{"Als"}
    TRPM8 -->|"expressed in"| Als
    Ms{"Ms"}
    TRPM8 -->|"expressed in"| Ms
    Inflammation{"Inflammation"}
    TRPM8 -->|"expressed in"| Inflammation
    ALS{"ALS"}
    TRPM8 -->|"expressed in"| ALS
    KCNK2["KCNK2"]
    TRPM8 -->|"expressed in"| KCNK2
    TNF["TNF"]
    TRPM8 -->|"expressed in"| TNF
    TNF__["TNF-Alpha"]
    TRPM8 -->|"expressed in"| TNF__
    INFLAMMATION["INFLAMMATION"]
    TRPM8 -->|"expressed in"| INFLAMMATION
    TRPA1["TRPA1"]
    TRPM8 -->|"expressed in"| TRPA1
    T_Cell["T Cell"]
    TRPM8 -->|"expressed in"| T_Cell
    neurodegeneration["neurodegeneration"]
    TRPM8 -->|"implicated in"| neurodegeneration
    TNF__ -->|"upregulates"| TRPM8
    TNFA["TNFA"]
    TNFA -->|"activates"| TRPM8
    PIEZO1["PIEZO1"]
    PIEZO1 -->|"expressed in"| TRPM8
    KCNK2 -->|"expressed in"| TRPM8
    TNF -->|"expressed in"| TRPM8
    TRPA1 -->|"expressed in"| TRPM8
    TNF__ -->|"expressed in"| TRPM8
    INFLAMMATION -->|"expressed in"| TRPM8
    AND["AND"]
    AND -->|"expressed in"| TRPM8
    style TRPM8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0