Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBE2K: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | UBE2K |
| Full Name | Ubiquitin Conjugating Enzyme E2 K |
| Chromosome | 1p34.3 |
| Protein Type | Enzyme |
| Molecular Weight | 22 kDa |
| Amino Acids | 150 aa |
| Pathways | NF-κB |
| UniProt ID | P61006 |
| Ensembl ID | ENSG00000109381 |
| GeneCards | UBE2K |
| Human Protein Atlas | UBE2K |
| Ubiquitination | Catalyzes ubiquitin chain formation |
| K63-linked chains | Generates K63-linked polyubiquitin |
| DNA repair | Involved in DNA damage response |
| [NF-κB](/entities/nf-kb) signaling | Regulates inflammatory responses |
| Associated Diseases | neurodegeneration |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
UBE2K["UBE2K"]
Als{"Als"}
UBE2K -->|"expressed_in"| Als
Fibrosis{"Fibrosis"}
UBE2K -->|"expressed_in"| Fibrosis
Necroptosis{"Necroptosis"}
UBE2K -->|"expressed_in"| Necroptosis
Cancer{"Cancer"}
UBE2K -->|"expressed_in"| Cancer
RPL14["RPL14"]
UBE2K -->|"associated_with"| RPL14
EEF2["EEF2"]
UBE2K -->|"associated_with"| EEF2
CREB1["CREB1"]
UBE2K -->|"expressed_in"| CREB1
Macrophage["Macrophage"]
UBE2K -->|"expressed_in"| Macrophage
Rb("Rb")
UBE2K -->|"associated_with"| Rb
Actin("Actin")
UBE2K -->|"expressed_in"| Actin
ARID1A["ARID1A"]
ARID1A -->|"associated_with"| UBE2K
CANX["CANX"]
CANX -->|"associated_with"| UBE2K
neurodegeneration["neurodegeneration"]
UBE2K -->|"implicated_in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Fibrosis | expressed_in | disease | 0.65 |
| Necroptosis | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| RPL14 | associated_with | gene | 0.60 |
| EEF2 | associated_with | gene | 0.60 |
| CREB1 | expressed_in | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| Macrophage | expressed_in | cell_type | 0.60 |
| Actin | expressed_in | protein | 0.60 |
| circadian regulation | participates_in | pathway | 0.55 |
| ubiquitin-proteasome | participates_in | pathway | 0.55 |
| autophagy pathway | participates_in | pathway | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||