protein

EEF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EEF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

153Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

Summary

EEF2 is a protein involved in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Autism. Connected to 80 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	EEF2
Full Name	Eukaryotic Translation Elongation Factor 2 (EEF2)
Chromosome	19p13.3
Protein Type	Gene
Function	is a GTP-dependent molecular motor that catalyzes the translocation step of protein synthesis, moving the peptidyl-tRNA from the A-site to the P-site of the ribosome with each elongation cycle.
Molecular Weight	95.4 kDa
Amino Acids	739 aa
Pathways	Mtor, Synaptic Plasticity, Wnt
NCBI Gene ID	Search NCBI
GeneCards	EEF2
Human Protein Atlas	EEF2
Associated Diseases	Als, Cardiovascular, Ischemia, Ms
Interactions	PKC, TNF, AKT, P38, REST, CCL5
KG Connections	152 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EEF2["EEF2"] -->|"regulates"| BDNF["BDNF"]
    EEF2["EEF2"] -.->|"inhibits"| NMDAR["NMDAR"]
    EEF2["EEF2"] -.->|"inhibits"| eEF2K["eEF2K"]
    EEF2["EEF2"] -->|"phosphorylates"| TAOK2["TAOK2"]
    EEF2["EEF2"] -->|"binds"| CPEB2["CPEB2"]
    EEF2["EEF2"] -->|"phosphorylates"| LRRK2["LRRK2"]
    P38["P38"] -->|"activates"| EEF2["EEF2"]
    AKT["AKT"] -->|"activates"| EEF2["EEF2"]
    CD4["CD4"] -->|"interacts"| EEF2["EEF2"]
    MAPK3["MAPK3"] -->|"interacts"| EEF2["EEF2"]
    style EEF2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (106)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
BDNF	upregulates	gene	0.90
NMDAR	inhibits	receptor	0.90
eEF2K	inhibits	gene	0.90
TAOK2	phosphorylates	gene	0.90
CPEB2	binds	gene	0.90
LRRK2	phosphorylates	gene	0.80
eIF2α	phosphorylates	protein	0.80
eIF2s2	phosphorylates	protein	0.80
Stm1	binds	protein	0.80
HIF-1α	inhibits	gene	0.80
LDHA	binds	gene	0.80
NADH	binds	chemical	0.80
Tumor	activates	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Ms	regulates	disease	0.65
Autism	regulates	disease	0.65
Als	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Depression	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Depression	inhibits	disease	0.65
Aging	activates	disease	0.65
Als	expressed_in	disease	0.65
Fibrosis	expressed_in	disease	0.65
Necroptosis	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
PKC	activates	gene	0.60
TNF	activates	gene	0.60
AKT	activates	gene	0.60
P38	activates	gene	0.60
REST	inhibits	gene	0.60
CCL5	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
TLR7	interacts_with	gene	0.60
CAT	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
RAC2	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
CDK4	interacts_with	gene	0.60
CDKN1A	interacts_with	gene	0.60
LCK	interacts_with	gene	0.60
SOD1	regulates	gene	0.60
FZD9	regulates	gene	0.60

Incoming (47)

Source	Relation	Type	Str
Cholix	targets	entity	1.00
ds-83b31ef18d49	data_in	dataset	1.00
P38	activates	gene	0.60
AKT	activates	gene	0.60
CD4	interacts_with	gene	0.60
MAPK3	interacts_with	gene	0.60
ZAP70	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
CD19	interacts_with	gene	0.60
PIK3CA	regulates	gene	0.60
CD44	regulates	gene	0.60
SRC	regulates	gene	0.60
BNIP3	associated_with	gene	0.60
PKC	activates	gene	0.60
TNF	activates	gene	0.60
NLRP3	inhibits	gene	0.60
BDNF	activates	gene	0.60
GFAP	activates	gene	0.60
SNAP25	activates	gene	0.60
PSD95	activates	gene	0.60
EEF2K	inhibits	gene	0.60
HDAC1	activates	gene	0.60
BDNF	regulates	gene	0.60
MET	inhibits	gene	0.60
JNK	activates	gene	0.60
MTOR	activates	gene	0.60
CHR2	activates	gene	0.60
ARID1A	associated_with	gene	0.60
CANX	associated_with	gene	0.60
UBE2K	associated_with	gene	0.60
RPL14	associated_with	gene	0.60
MIRNAS	regulates	gene	0.60
MOTOR NEURONS	regulates	gene	0.60
MITOPHAGY	associated_with	gene	0.60
ROS	activates	gene	0.60
ERK	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
AND	activates	gene	0.60
DEPRESSION	activates	gene	0.60
AND	regulates	gene	0.60
DEPRESSION	inhibits	gene	0.60
MAPK	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
GENES	activates	gene	0.60
CAMKII	activates	gene	0.60
mTOR	activates	entity	0.50
benchmark_ot_ad_answer_key:EEF2	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EEF2

Understanding Entity Pages

Summary

Wiki Pages (16)

Eukaryotic Translation Elongation Factor 2 (EEF2)

RPL10A — Ribosomal Protein L10A

Protein Synthesis in Neurodegenerative Diseases

RPS11 — Ribosomal Protein S11

RPL28 — Ribosomal Protein L28

Ribosomal and Translation Dysfunction in Progressive Supranuclear Palsy

DARS1

EEF2K — Eukaryotic Elongation Factor 2 Kinase

FZD9 Gene

UBE2K Gene

eEF2 Protein

eEF1B2 Protein

FZD2 Gene

ZAP70 — Zeta Chain T-Cell Receptor Associated Protein Kinase 70