gene

CHMP7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

0Hypotheses

0Analyses

50Outgoing

30Incoming

Summary

Charged Multivesicular Body Protein 7 - hybrid ESCRT-III/CHMP4 protein involved in nuclear envelope sealing and autophagy

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🧬 Gene Info

Gene Symbol	CHMP7
Full Name	Charged Multivesicular Body Protein 7
Chromosome	8p21.3
Function	is a unique hybrid ESCRT-III/CHMP4 family member with distinct functions in both the endosomal system and nuclear envelope maintenance.
Pathways	CRISPR-Cas, oxidative stress response
UniProt ID	[Q9Y3X5](https://www.uniprot.org/uniprot/Q9Y3X5)
Ensembl ID	ENSG00000165457
GeneCards	CHMP7
Human Protein Atlas	CHMP7
Associated Diseases	ALS, Infection, Inflammation, Sepsis
Interactions	CHMP2B, CHMP4B, SMN, VPS4, Rb, VPS4A
KG Connections	107 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHMP7["<b>CHMP7</b>"]
    Neurodegeneration{"Neurodegeneration"}
    CHMP7 -->|"activates"| Neurodegeneration
    Als{"Als"}
    CHMP7 -->|"activates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    CHMP7 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    CHMP2B["CHMP2B"]
    CHMP7 -->|"activates"| CHMP2B
    neurodegeneration["neurodegeneration"]
    CHMP7 -->|"implicated in"| neurodegeneration
    style CHMP7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (77)

Target	Relation	Type	Str
Nuclear Pore Complex	associated_with	mechanism	0.90
Als Cellular Phenotypes	contributes_to	phenotype	0.90
Nuclear Pore	associated_with	process	0.90
TDP-43	modulates	protein	0.85
Motor Neuron	expressed_in	cell_type	0.85
SPLICING	inhibits	process	0.80
neurons	expressed_in	cell_type	0.70
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Infection	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Sepsis	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Aging	activates	disease	0.65
CHMP2B	activates	gene	0.60
CD8	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PRKACA	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
CD4	associated_with	gene	0.60
GCLM	associated_with	gene	0.60
STMN2	expressed_in	gene	0.60
CHMP4B	interacts_with	gene	0.60
SMN	interacts_with	gene	0.60
VPS4	interacts_with	gene	0.60
Rb	interacts_with	protein	0.60
SMN	activates	gene	0.60
VPS4	expressed_in	gene	0.60
VPS4	associated_with	gene	0.60
VPS4A	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Cholesterol	associated_with	pathway	0.60
Immunotherapy	associated_with	pathway	0.60
Ferroptosis	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Immune Response	associated_with	pathway	0.60
Pyroptosis	associated_with	pathway	0.60
ALS	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AND	activates	gene	0.60
Stem Cell	activates	cell_type	0.60
Neuron	interacts_with	cell_type	0.60
Tdp-43	causes	pathway	0.60

Incoming (30)

Source	Relation	Type	Str
RNA Splicing Inhibition	activates	process	0.95
SMN	regulates	protein	0.95
Rna Splicing Inhibition	promotes	process	0.95
SMD1	regulates	gene	0.92
SNRPD1	interacts_with	gene	0.90
ALS	expressed_in	gene	0.70
HTRA2	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
GBM	associated_with	gene	0.60
TDP-43	causes	gene	0.60
STMN2	expressed_in	gene	0.60
CHMP2B	interacts_with	gene	0.60
CHMP4B	interacts_with	gene	0.60
SMN	interacts_with	gene	0.60
VPS4	interacts_with	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
SMD1	interacts_with	gene	0.60
ALS	inhibits	gene	0.60
RNA	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
ALS	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
MOTOR NEURONS	activates	gene	0.60
AND	activates	gene	0.60
AND	interacts_with	gene	0.60
RNA SPLICING	causes	gene	0.60
ALS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHMP7

Understanding Entity Pages

Summary

Wiki Pages (12)

CHMP7 mutations cause hereditary spastic paraplegia

Alpha-Synuclein ESCRT-III Inhibition Mechanism

CHMP1A — Charged Multivesicular Body Protein 1A

CHMP3 — Charged Multivesicular Body Protein 3

CHMP1B — Charged Multivesicular Body Protein 1B

CHMP2B — Charged Multivesicular Body Protein 2B

Survival Motor Neuron (SMN)

STMN2 (Stathmin-2)

CHMP2B and ESCRT-III Dysfunction in Frontotemporal Dementia

CHMP2B