Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about YES1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | YES1 |
| Full Name | YES Proto-Oncogene 1, Src Family Tyrosine Kinase |
| Chromosome | 18p11.32 |
| Protein Type | Receptor |
| Function | Synaptic Plasticity: YES1 is enriched in synaptic fractions and regulates AMPA and NMDA receptor trafficking [4]. |
| Primary Expression | various tissues including the brain, where it participates in signaling pathways controlling cell proliferation, differentiation, and survival |
| Molecular Weight | 60 kDa |
| Amino Acids | 536 aa |
| UniProt ID | https://www.uniprot.org/uniprot/P42681 P42681 |
| Ensembl ID | ENSG00000106105 |
| GeneCards | YES1 |
| Human Protein Atlas | YES1 |
| Associated Diseases | neurodegeneration |
| Interactions | SOX9, HNRNPA2B1, YWHAH, FUS, AND, CYTOKINES |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
YES1["<b>YES1</b>"]
Als{"Als"}
YES1 -->|"therapeutic target"| Als
Cancer{"Cancer"}
YES1 -->|"therapeutic target"| Cancer
Tumor{"Tumor"}
YES1 -->|"therapeutic target"| Tumor
CANCER["CANCER"]
YES1 -->|"therapeutic target"| CANCER
Mapk(["Mapk"])
YES1 -->|"therapeutic target"| Mapk
neurodegeneration["neurodegeneration"]
YES1 -->|"implicated in"| neurodegeneration
FYN["FYN"]
FYN -->|"expressed in"| YES1
ERK["ERK"]
ERK -->|"therapeutic target"| YES1
SRC["SRC"]
SRC -->|"expressed in"| YES1
style YES1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Obesity | therapeutic_target | disease | 0.65 |
| Cardiovascular | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| SRC | associated_with | gene | 0.60 |
| ATF1 | therapeutic_target | gene | 0.60 |
| SOX9 | activates | gene | 0.60 |
| HNRNPA2B1 | activates | gene | 0.60 |
| YWHAH | activates | gene | 0.60 |
| FUS | activates | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| Mapk | therapeutic_target | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| YAP | associated_with | gene | 0.60 |
| CREB | therapeutic_target | gene | 0.60 |
| KRAS | associated_with | gene | 0.60 |
| AND | activates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| YAP | activates | gene | 0.60 |
| IL-6 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||