Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHOLINERGIC NEURONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CHOLINERGIC NEURONS |
graph TD
CHOLINERGIC_NEURONS[CHOLINERGIC NEURONS]
CHOLINERGIC_NEURONS -->|active_in| calcium_signaling[calcium signaling]
CHOLINERGIC_NEURONS -->|active_in| oxidative_stress_response[oxidative stress response]
CHOLINERGIC_NEURONS -->|active_in| senescence[senescence]
Alzheimer_s_disease[Alzheimer's disease] -->|affects| CHOLINERGIC_NEURONS
neurodegeneration[neurodegeneration] -->|affects| CHOLINERGIC_NEURONS
NGF[NGF] -->|implicated in| CHOLINERGIC_NEURONS
adenosine_receptor[adenosine receptor] -->|expressed in| CHOLINERGIC_NEURONS
anxiety[anxiety] -->|affects| CHOLINERGIC_NEURONS
aging[aging] -->|affects| CHOLINERGIC_NEURONS
glioblastoma[glioblastoma] -->|affects| CHOLINERGIC_NEURONS
Parkinson_s_disease[Parkinson's disease] -->|affects| CHOLINERGIC_NEURONS
CD38[CD38] -->|expressed in| CHOLINERGIC_NEURONS| Target | Relation | Type | Str |
|---|---|---|---|
| calcium signaling | active_in | pathway | 0.55 |
| oxidative stress response | active_in | pathway | 0.55 |
| senescence | active_in | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | affects | disease | 0.90 |
| aging | affects | disease | 0.60 |
| glioblastoma | affects | disease | 0.60 |
| Parkinson's disease | affects | disease | 0.60 |
| neurodegeneration | affects | disease | 0.60 |
| NGF | implicated_in | gene | 0.60 |
| NGF | regulates | gene | 0.60 |
| NGF | associated_with | gene | 0.60 |
| adenosine receptor | expressed_in | receptor | 0.60 |
| anxiety | affects | disease | 0.60 |
| RNA | expressed_in | gene | 0.55 |
| CD38 | expressed_in | gene | 0.55 |
| CHAT | expressed_in | gene | 0.55 |
| PNN | expressed_in | gene | 0.55 |
| NTS | expressed_in | gene | 0.55 |
| CHRNA7 | expressed_in | gene | 0.55 |
| ADRA2A | expressed_in | gene | 0.55 |
| TH | expressed_in | gene | 0.55 |
| HCN1 | expressed_in | gene | 0.55 |
| MMP2 | expressed_in | gene | 0.55 |
| MMP9 | expressed_in | gene | 0.55 |
| P300 | expressed_in | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity