gene

NTS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

175Connections

3Hypotheses

30Analyses

50Outgoing

50Incoming

Summary

NTS is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, activates, expressed in. Associated with ALS, Aging, Als. Connected to 96 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NTS
Full Name	Neurotensin
Chromosome	12q13.13
Function	The peptide is derived from a 169-amino acid precursor that also produces the related hexapeptide neuromedin N.
Primary Expression	the substantia nigra, particularly in the pars reticulata
Amino Acids	13 aa
Pathways	MAPK, MAPK pathway
UniProt ID	P30990
NCBI Gene ID	4902
Ensembl ID	ENSG00000133636
OMIM	162650
GeneCards	NTS
Human Protein Atlas	NTS
Neurochemical	Function
5-HT3 receptors	Serotonin-mediated signaling
Associated Diseases	ALS, Migraine, stroke
Interactions	ARC, TNF, BIP, HSPA5, MUL1, NBR1
KG Connections	175 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NTS — AlphaFold P30990 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NTS["NTS"]
    NTS -.protects against.-> Ischemia["Ischemia"]
    NTS -->|"target for"| Aging["Aging"]
    NTS -->|"target for"| Stroke["Stroke"]
    NTS -->|"regulates"| Ms["Ms"]
    NTS -->|"regulates"| Obesity["Obesity"]
    NTS -->|"interacts"| Als["Als"]
    NTS -.biomarker for.-> Inflammation["Inflammation"]
    NTS -.biomarker for.-> Atherosclerosis["Atherosclerosis"]
    ANXA1["ANXA1"] -.protects against.-> NTS
    NBR1["NBR1"] -->|"activates"| NTS
    TNF["TNF"] -->|"inhibits"| NTS
    CRH["CRH"] -->|"regulates"| NTS
    POMC["POMC"] -->|"regulates"| NTS
    NR4A2["NR4A2"] -.biomarker for.-> NTS
    CXCL2["CXCL2"] -.biomarker for.-> NTS
    CSF2["CSF2"] -.biomarker for.-> NTS
    MSR1["MSR1"] -.biomarker for.-> NTS
    STAT3["STAT3"] -.biomarker for.-> NTS

Outgoing (112)

Target	Relation	Type	Str
LDLR	correlates_with	gene	0.80
Ischemia	protects_against	disease	0.65
Aging	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Ms	regulates	disease	0.65
Obesity	regulates	disease	0.65
Als	interacts_with	disease	0.65
Inflammation	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Aging	protects_against	disease	0.65
Stroke	protects_against	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Stroke	activates	disease	0.65
Aging	activates	disease	0.65
ALS	interacts_with	disease	0.65
ALS	biomarker_for	disease	0.65
Migraine	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Diabetes	activates	disease	0.65
Cancer	activates	disease	0.65
ARC	interacts_with	gene	0.60
NPY	regulates	gene	0.60
IL1A	biomarker_for	gene	0.60
LDLR	associated_with	gene	0.60
ANXA1	protects_against	gene	0.60
NR4A2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
TNF	inhibits	gene	0.60
POMC	regulates	gene	0.60
BIP	inhibits	gene	0.60
HSPA5	inhibits	gene	0.60
MUL1	inhibits	gene	0.60
NBR1	activates	gene	0.60
CX3CR1	associated_with	gene	0.60
HTR3C	biomarker_for	gene	0.60
TRPV1	activates	gene	0.60
ERK2	activates	gene	0.60
CRH	regulates	gene	0.60
NPY	activates	gene	0.60
SST	activates	gene	0.60
Leptin	interacts_with	protein	0.60

Incoming (63)

Source	Relation	Type	Str
ANXA1	protects_against	gene	0.60
NBR1	activates	gene	0.60
CX3CR1	associated_with	gene	0.60
TNF	inhibits	gene	0.60
CRH	regulates	gene	0.60
POMC	regulates	gene	0.60
NR4A2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
ARC	interacts_with	gene	0.60
NPY	regulates	gene	0.60
IL1A	biomarker_for	gene	0.60
UBIQUITIN	activates	gene	0.60
LDLR	associated_with	gene	0.60
ANXA1	regulates	entity	0.60
ANXA1	associated_with	entity	0.60
ANXA1	therapeutic_target	entity	0.60
ANXA1	expressed_in	entity	0.60
NBR1	regulates	entity	0.60
LDLR	biomarker_for	entity	0.60
ERK1	activates	gene	0.60
SST	activates	gene	0.60
NPY	activates	gene	0.60
ANXA1	activates	gene	0.60
CSF2	co_expressed_with	gene	0.60
LDLR	co_expressed_with	gene	0.60
CSF2	associated_with	gene	0.60
CX3CR1	binds_to	gene	0.60
ANXA1	inhibits	gene	0.60
MAP6	regulates	gene	0.60
LDH	associated_with	gene	0.60
MSR1	biomarker_for	gene	0.60
IL13RA1	biomarker_for	gene	0.60
GENES	regulates	gene	0.60
NFKB	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	activates	gene	0.60
STROKE	activates	gene	0.60
NEURON	protects_against	gene	0.60
TNF-Α	inhibits	gene	0.60
MICROGLIA	protects_against	gene	0.60
AUTOPHAGY	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
TNFRSF19	biomarker_for	gene	0.60
BRAIN INJURY	contributes_to	gene	0.60
CCR9	biomarker_for	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.605	neuroinflammation	What molecular mechanisms drive the tran
TFAM overexpression creates mitochondrial donor-recipient gr	0.474	neurodegeneration	Mitochondrial transfer between astrocyte
C1q Inhibition Prevents Synaptic Mitochondrial Dysfunction v	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673]	Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge	Autophagy	2024	1
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142]	Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha	Nat Cell Biol	2024	1
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090]	Lin MM, Liu N, Qin ZH, Wang Y	Acta Pharmacol Sin	2022	1
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic [PMID:33408785]	Zhao M, Wang Y, Li L, Liu S, Wang C, Yua	Theranostics	2021	1
Mitochondrial DNA copy number in human disease: the more the better? [PMID:33314045]	Filograna R, Mennuni M, Alsina D, Larsso	FEBS Lett	2021	1
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434]	Li C, Zhang Y, Liu J, Kang R, Klionsky D	Autophagy	2021	1
Butyrate extends health and lifespan in mice with mitochondrial deficiency. [PMID:41826362]	["Gaband\u00e9-Rodr\u00edguez E", "G\u00	Nature communications	2026	0
Vav-iCre-Mediated Deletion of TFAM Is Not Recoverable and Is Consistent with Emb [PMID:41898789]	["Ghosh R", "Shakur E", "Yousefzadeh M"]	Genes	2026	0
NRIP1 co-activates nuclear translocated FOXO3 to upregulate TFAM expression and [PMID:41888517]	["Zha Y", "Huang H", "Liu Y", "Wan M", "	Cell death discovery	2026	0
miR-137-5p-Loaded Milk-Derived Small Extracellular Vesicles Modulate Oxidative S [PMID:41754992]	["G\u00f6n\u00fcll\u00fc S", "Ayd\u0131n	Pharmaceutics	2026	0
Ginseng stem and leaf saponins attenuates pulmonary fibrosis by regulating TFAM- [PMID:41911987]	Chen Y, Hu L, Fu Q, Chen H, Jiang Z, Li	Journal of ethnopharmacology	2026	0
NIPSNAP3B elevates mitochondrial biogenesis to attenuate lipid accumulation in c [PMID:41587668]	Li K, Wang M, Liu Y, Lu R, Zhang H et al	Gene	2026	0
Icariin, astragaloside IV and puerarin mixture salvages synaptic loss by enhanci [PMID:41934898]	Zhong J, He X, Yang H, Zhang J, Liu J et	Biomed Pharmacother	2026	0
Structural Analysis of Human LonP1 Protease Bound with the Native Substrate. [PMID:41900996]	Li M, Liu H, Zhang S, Gao Q, Li S, Wang	Life (Basel, Switzerland)	2026	0
Effect of (-)-Epicatechin on Mitochondrial Homeostasis in Skeletal Muscle of Fem [PMID:41900149]	Herrera-Cogco EC, Herrera-Meza S, Martín	Molecules (Basel, Switzerland)	2026	0
Enhancing the Optical Properties of MAPbI3 Perovskites Passivated with Coordinat [PMID:41908442]	Gamarde M, Jouaiti A, Chartrand D, Antho	ACS omega	2026	0
Butyrate extends health and lifespan in mice with mitochondrial deficiency. [PMID:41648569]	["Gaband\u00e9-Rodr\u00edguez E", "G\u00	bioRxiv : the preprint server	2026	0
PM [PMID:41897431]	["Somayajulu M", "Wright R", "Muhammed F	Antioxidants (Basel, Switzerla	2026	0
m6A deficiency induces dopaminergic neurodegeneration and progressive parkinsoni [PMID:41842966]	["Liu S", "Ren Q", "Mo G", "Li Z", "Huan	The Journal of clinical invest	2026	0
In vitro investigation of miR-206-3p-loaded extracellular vesicles as modulators [PMID:41592400]	["G\u00f6n\u00fcll\u00fc S", "Ayd\u0131n	Biochemical and biophysical re	2026	0

NTS

Understanding Entity Pages

Summary

Wiki Pages (21)

Area Postrema Neurons in Chemotherapy-Induced Nausea

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Neuroresilience Mechanisms and Evidence

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

NTF4 Protein

Growth Factor Therapies

Neurotrophin Signaling Pathways in Neurodegeneration

Paraventricular Hypothalamic Nucleus (PVN) Neurons

FEEMSA Study: Laryngopharyngeal Function in Neurodegenerative Diseases (NCT04706234)

vitamin-d-therapy-neurodegeneration

Growth Factor Therapeutics: Investment Landscape Analysis

Braak Staging and Tau Propagation Pathway

Gut-Brain Axis in Neurodegeneration

Wallerian Degeneration

Remyelination in Neurodegeneration

Neurotrophic Factors in Neurodegeneration

BDNF/Neurotrophin Signaling in Neurodegeneration

Vagal Nerve Stimulation for Parkinson's Disease (NCT07226284)

Section 103: Neurotrophic Factor Therapies in CBS/PSP

Non-Dopaminergic Neurotransmitter Degeneration as Upstream Driver in Parkinson's Disease

cortisol-tau-pathway

Pathway Diagram

Outgoing (112)

Incoming (63)

Targeting Hypotheses (3)

Mentioning Analyses (30)

What are the specific molecular determinants that govern tau strain selection du

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

Are interneuron oscillation deficits compensatory responses or primary pathologi

Do CXCL10-recruited CD8+ T cells provide neuroprotection or cause damage in agin

What molecular mechanisms explain how apoE promotes cerebral amyloid angiopathy

What are the molecular mechanisms by which GLP-1RAs provide neuroprotective effe

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

What determines blood-brain barrier penetration kinetics for specialized pro-res

What is the therapeutic window between insufficient and toxic levels of TDP-43 a

Is HCN1 dysfunction causal or protective in EC layer II neurodegeneration?

What are the molecular determinants that control directional mitochondrial trans

What is the high-resolution structure of the APOE4 hinge region and its role in

Can biased TREM2 agonists selectively activate DAP12-SYK-PI3K without triggering

What specific gene expression signatures in aging mouse brain predict human AD v

How can Allen Aging Mouse Brain Atlas data be systematically cross-referenced wi

Which specific cell types show greatest vulnerability in AD based on SEA-AD tran

How can circuit-level neurodegeneration mechanisms be identified without complet

Do tau aggregates represent protective responses or primary pathogenic drivers i

What validated biomarkers can determine optimal TFEB activity windows during dis

What is the optimal ketone dosing threshold to avoid metabolic steal syndrome wh

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

What is the therapeutic window between GCS inhibition efficacy and systemic toxi

What distinguishes truly senescent brain cells from merely dysfunctional reactiv

Does structural 'normalization' of APOE4 domain interactions actually improve am

What is the optimal BBB opening duration and spatial precision to maximize thera

Do tau-specific HSP90 conformational states exist that differ from other client

Related Papers (20)