gene

NTS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

170Connections

30Hypotheses

0Analyses

50Outgoing

50Incoming

12Experiments

0Debates

Summary

NTS is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, activates, expressed in. Associated with ALS, Aging, Als. Connected to 96 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NTS
Full Name	Neurotensin
Chromosome	12q13.13
Function	The peptide is derived from a 169-amino acid precursor that also produces the related hexapeptide neuromedin N.
Primary Expression	the substantia nigra, particularly in the pars reticulata
Amino Acids	13 aa
Pathways	MAPK, MAPK pathway
UniProt ID	P30990
NCBI Gene ID	4902
Ensembl ID	ENSG00000133636
OMIM	162650
GeneCards	NTS
Human Protein Atlas	NTS
Associated Diseases	ALS, Migraine, stroke
Interactions	AND, ANXA1, ARC, AUTOPHAGY, BDNF, BIP
KG Connections	170 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NTS — AlphaFold P30990 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NTS["NTS"]
    NTS -.protects against.-> Ischemia["Ischemia"]
    NTS -->|"target for"| Aging["Aging"]
    NTS -->|"target for"| Stroke["Stroke"]
    NTS -->|"regulates"| Ms["Ms"]
    NTS -->|"regulates"| Obesity["Obesity"]
    NTS -->|"interacts"| Als["Als"]
    NTS -.biomarker for.-> Inflammation["Inflammation"]
    NTS -.biomarker for.-> Atherosclerosis["Atherosclerosis"]
    ANXA1["ANXA1"] -.protects against.-> NTS
    NBR1["NBR1"] -->|"activates"| NTS
    TNF["TNF"] -->|"inhibits"| NTS
    CRH["CRH"] -->|"regulates"| NTS
    POMC["POMC"] -->|"regulates"| NTS
    NR4A2["NR4A2"] -.biomarker for.-> NTS
    CXCL2["CXCL2"] -.biomarker for.-> NTS
    CSF2["CSF2"] -.biomarker for.-> NTS
    MSR1["MSR1"] -.biomarker for.-> NTS
    STAT3["STAT3"] -.biomarker for.-> NTS

Outgoing (108)

Target	Relation	Type	Str
LDLR	associated_with	gene	0.80
Ischemia	protects_against	disease	0.65
Stroke	protects_against	disease	0.65
Als	biomarker_for	disease	0.65
Cancer	inhibits	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Stroke	activates	disease	0.65
Migraine	associated_with	disease	0.65
Als	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Ms	biomarker_for	disease	0.65
Aging	protects_against	disease	0.65
Inflammation	activates	disease	0.65
Tumor	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
ALS	biomarker_for	disease	0.65
Diabetes	activates	disease	0.65
Inflammation	biomarker_for	disease	0.65
Obesity	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	activates	disease	0.65
Atherosclerosis	biomarker_for	disease	0.65
Aging	therapeutic_target	disease	0.65
MUL1	inhibits	gene	0.60
stroke	associated_with	disease	0.60
stroke	protects_against	disease	0.60
striatum	expressed_in	brain_region	0.60
thalamus	expressed_in	brain_region	0.60
HSPA5	inhibits	gene	0.60
JAK1	biomarker_for	gene	0.60
Leptin	interacts_with	protein	0.60
SST	activates	gene	0.60
BIP	inhibits	gene	0.60
NPY	activates	gene	0.60
CRH	regulates	gene	0.60
POMC	regulates	gene	0.60
CXCL2	biomarker_for	gene	0.60
IL1A	biomarker_for	gene	0.60
ERK2	activates	gene	0.60
TRPV1	activates	gene	0.60
TNF	inhibits	gene	0.60
Autophagy	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
HTR3C	biomarker_for	gene	0.60
Apoptosis	expressed_in	pathway	0.60
Long-Term Potentiation	associated_with	pathway	0.60
CX3CR1	associated_with	gene	0.60
STAT3	biomarker_for	gene	0.60

Incoming (62)

Source	Relation	Type	Str
IL13RA1	associated_with	gene	0.60
NBR1	activates	gene	0.60
TNF	inhibits	gene	0.60
CRH	regulates	gene	0.60
POMC	regulates	gene	0.60
NR4A2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
STAT3	biomarker_for	gene	0.60
MMP9	biomarker_for	gene	0.60
JAK1	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
ARC	interacts_with	gene	0.60
NPY	regulates	gene	0.60
IL1A	biomarker_for	gene	0.60
ERK1	activates	gene	0.60
SST	activates	gene	0.60
NPY	activates	gene	0.60
ANXA1	activates	gene	0.60
CSF2	co_expressed_with	gene	0.60
LDLR	co_expressed_with	gene	0.60
CSF2	associated_with	gene	0.60
RNA	biomarker_for	gene	0.60
CCR9	associated_with	gene	0.60
ANXA1	protects_against	gene	0.60
NFKB	activates	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	activates	gene	0.60
STROKE	activates	gene	0.60
NEURON	protects_against	gene	0.60
TNF-Α	inhibits	gene	0.60
MICROGLIA	protects_against	gene	0.60
INFLAMMATION	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
MAP6	regulates	gene	0.60
MSR1	biomarker_for	gene	0.60
CCR9	biomarker_for	gene	0.60
ANXA1	inhibits	gene	0.60
TNFRSF19	biomarker_for	gene	0.60
BRAIN INJURY	contributes_to	gene	0.60
LDH	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
LDLR	associated_with	gene	0.60
ANXA1	regulates	entity	0.60
ANXA1	associated_with	entity	0.60
ANXA1	therapeutic_target	entity	0.60
ANXA1	expressed_in	entity	0.60
NBR1	regulates	entity	0.60
LDLR	biomarker_for	entity	0.60
IL13RA1	biomarker_for	gene	0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Exposed amyloidogenic segments (β-sheet propensity residues)	0.840	protein-biochemistry	Do chaperones selectively recognize path
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven	0.819	neurodegeneration	Lipid raft composition changes in synapt
Targeting the Mechanistic Link Between AQP4 Dysfunction and	0.803	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
Focused Ultrasound with Microbubble Contrast Agents for Anti	0.762	neurodegeneration	Blood-brain barrier antibody transport m

PD-Associated GWAS Variants in CTSO and CTSF Genes Create a	0.743	neurodegeneration	-
VPS35 retromer activation prevents endosomal tau templating	0.740	neurodegeneration	Which tau propagation mechanism predomin
SNCA Oligomer Binding to LAMP2A Cytosolic Tail Prevents Tors	0.733	neurodegeneration	-
TFAM overexpression creates mitochondrial donor-recipient gr	0.725	neurodegeneration	Mitochondrial transfer between astrocyte
SASP-Secreted MMP-9 from Senescent Microglia Generates Patho	0.718	als	What are the mechanisms by which microgl
Liquid-to-Solid Transition Pathology Reveals Granule Weak Po	0.712	neurodegeneration	What determines the specificity of RNA-p
Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellu	0.705	-	What blood-brain barrier permeability ch
Focused Ultrasound with Microbubble Contrast Agents	0.684	drug-delivery	Can IGFBPL1 therapeutics effectively cro
CDK5 Inhibition at Presynaptic Terminals Prevents Activity-D	0.640	neurodegeneration	Investigate prion-like spreading of tau
Chaperone-Degradation Coupling Prevents Aggregate Persistenc	0.632	protein-folding	Can chaperone enhancement approaches ove
PD genetic aging variants accelerating cell-type-specific ep	0.626	neurodegeneration	Genetic Aging Landscape Variants and Epi
RNA-binding protein condensate maturation from reversible ph	0.626	neurodegeneration	Biophysical Determinants Shifting FUS/TD
Selective cathepsin B inhibition prevents cathepsin leakage-	0.620	neuroscience	Lysosomal dysfunction and cathepsin leak
Cell-state stratification is required to resolve Genetic Agi	0.612	neurodegeneration	Genetic Aging Landscape Variants and Epi
Cell-state stratification is required to resolve Biophysical	0.612	neurodegeneration	Biophysical Determinants Shifting FUS/TD
H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcr	0.610	neurodegeneration	Investigate mechanisms of epigenetic rep
NLRP3 Inflammasome Inhibition Prevents Synapse Loss via IL-1	0.610	neurodegeneration	Test Preregistration Analysis
Astrocyte LRP1-mediated tau uptake and APOE4-dependent secre	0.610	neurodegeneration	Which tau propagation mechanism predomin
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Genetic Aging Landscape Variants and Epi
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	Biophysical Determinants Shifting FUS/TD
STING Antagonism Prevents Acute-to-Chronic Neuroinflammation	0.601	neuroinflammation	What molecular mechanisms drive the tran
Residual Vascular Amyloid Prevents Complete CSF p-tau217 Nor	0.585	-	Can CSF p-tau217 normalization serve as
A lower trazodone dose of 50-100 mg nightly may be sufficien	0.580	neurodegeneration	-
LAMP-2 replacement therapy prevents lysosomal membrane perme	0.580	neuroscience	Lysosomal dysfunction and cathepsin leak
TFEB Activation Clears Tau-Loaded Endolysosomal Compartments	0.560	neurodegeneration	Investigate prion-like spreading of tau

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (12)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
IRI-AKI mouse model with mtROS inhibition	validation	ischemic acute kidney injury	0.900	0.00	IRI-AKI mice	proposed	N/A
mtROS effects on TFAM and mtDNA in HK2 cells	exploratory	acute kidney injury	0.900	0.00	HK2 cells	proposed	N/A
TFAM knockdown functional analysis	exploratory	acute kidney injury	0.850	0.00	HK2 cells	proposed	N/A
TFAM and mtDNA analysis in AKI patients	clinical	acute kidney injury	0.800	0.00	human patients	proposed	N/A
Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat	in_vivo	post-cardiac-arrest neurodegen	0.768	0.72	Sprague-Dawley rat asphyxial c	abandoned	$48,000
s:** - Test MCU overexpression specifically in layer II neurons in hea	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$200,000
Proposed experiment from debate on Mitochondrial transfer between astr	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Selective Vulnerability of Dopaminergic Neurons — Mechanism and Protec	validation	Neurodegeneration	0.400	0.50	cell_line	proposed	$160,000
Exercise-BDNF-Mitophagy Biomarker Study in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Ferroptosis Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
GLP-1 Agonist Neuroprotection Mechanism in PD	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673]	Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge	Autophagy	2024	1
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142]	Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha	Nat Cell Biol	2024	1
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090]	Lin MM, Liu N, Qin ZH, Wang Y	Acta Pharmacol Sin	2022	1
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic [PMID:33408785]	Zhao M, Wang Y, Li L, Liu S, Wang C, Yua	Theranostics	2021	1
Mitochondrial DNA copy number in human disease: the more the better? [PMID:33314045]	Filograna R, Mennuni M, Alsina D, Larsso	FEBS Lett	2021	1
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434]	Li C, Zhang Y, Liu J, Kang R, Klionsky D	Autophagy	2021	1
Butyrate extends health and lifespan in mice with mitochondrial deficiency. [PMID:41826362]	["Gaband\u00e9-Rodr\u00edguez E", "G\u00	Nature communications	2026	0
Vav-iCre-Mediated Deletion of TFAM Is Not Recoverable and Is Consistent with Emb [PMID:41898789]	["Ghosh R", "Shakur E", "Yousefzadeh M"]	Genes	2026	0
NRIP1 co-activates nuclear translocated FOXO3 to upregulate TFAM expression and [PMID:41888517]	["Zha Y", "Huang H", "Liu Y", "Wan M", "	Cell death discovery	2026	0
miR-137-5p-Loaded Milk-Derived Small Extracellular Vesicles Modulate Oxidative S [PMID:41754992]	["G\u00f6n\u00fcll\u00fc S", "Ayd\u0131n	Pharmaceutics	2026	0
Ginseng stem and leaf saponins attenuates pulmonary fibrosis by regulating TFAM- [PMID:41911987]	Chen Y, Hu L, Fu Q, Chen H, Jiang Z, Li	Journal of ethnopharmacology	2026	0
Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtD [PMID:41480405]	Li S, Yan Z, Zhi X, Zheng W, Zhang Z et	Bioact Mater	2026	0
Comprehensive multi-omics analysis and experimental validation indicate that VPS [PMID:41531939]	Wan D, Qi Y, Kang Y, Liang F, Wang Q et	RSC Med Chem	2026	0
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906]	Gao Z, Wang Y, Ren Y, Lyu J	J Neurochem	2026	0
VPS35 Deficiency Markedly Reduces the Proliferation of HEK293 Cells. [PMID:41751560]	Lee S, Park S, Bang H, Kim SU, Park YH e	Genes (Basel)	2026	0
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663]	Song P, Chen C, Franchini R, Duong B, Wa	J Clin Invest	2026	0
ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085]	Wen H, Zi Y, Liu Z, Bai Y, Lin J et al.	Cell Death Differ	2026	0
The VPS35 protein and the role of its impairments in mitochondrial dysfunction i [PMID:41841708]	Buneeva OA, Medvedev AE	Biomed Khim	2026	0
Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation [PMID:41846978]	Deng IB, Bu M, Follett J, Sharp R, Mamai	bioRxiv	2026	0
Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C [PMID:41912440]	Santinelli L, Pratuseviciute N, Lange LM	Mov Disord	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NTS in their description or question text

NTS

Understanding Entity Pages

Summary

Wiki Pages (6)

NTS — Neurotensin

NTSR2 Gene

Nucleus of the Solitary Tract (NTS) Expanded

NTSR1 — Neurotensin Receptor 1

Nucleus of the Solitary Tract (NTS) Neurons

Nucleus of the Solitary Tract (NTS) Neurons

Pathway Diagram

Outgoing (108)

Incoming (62)

Targeting Hypotheses (30)

Mentioning Analyses (0)

Experiments (12)

Related Papers (20)

Debates (0)

Related Research

VPS35 retromer activation prevents endosomal tau templating across all brain reg

TFAM overexpression creates mitochondrial donor-recipient gradients for directed

SASP-Secreted MMP-9 from Senescent Microglia Generates Pathological TDP-43 C-Ter

Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellular BBB Breakdown fr

Focused Ultrasound with Microbubble Contrast Agents

CDK5 Inhibition at Presynaptic Terminals Prevents Activity-Dependent Tau Release

Chaperone-Degradation Coupling Prevents Aggregate Persistence by Shunting Seeds

PD genetic aging variants accelerating cell-type-specific epigenetic clock traje

RNA-binding protein condensate maturation from reversible phase separation to am

Selective cathepsin B inhibition prevents cathepsin leakage-mediated NLRP3 infla

Cell-state stratification is required to resolve Genetic Aging Landscape Variant

Cell-state stratification is required to resolve Biophysical Determinants Shifti