pathway

unfolded protein response

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about unfolded protein response: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1129Connections

0Hypotheses

0Analyses

37Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	unfolded protein response
Summary	# [Unfolded Protein Response](/entities/unfolded-protein-response)[/entities/unfolded-protein-response](entities/unfolded-protein-response) ## Introduction [Unfolded Protein Response](/entities/unfol
Related Diseases	ER homeostasis, BAX/BCL-2 ratio
Related Pathways	lipid metabolism

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    unfolded_protein_response["unfolded protein response"] -->|"regulates"| ER_homeostasis["ER homeostasis"]
    style ER_homeostasis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    unfolded_protein_response["unfolded protein response"] -->|"upstream of"| BAX_BCL_2_ratio["BAX/BCL-2 ratio"]
    style BAX_BCL_2_ratio fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    unfolded_protein_response["unfolded protein response"] -->|"active in"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    unfolded_protein_response["unfolded protein response"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    unfolded_protein_response["unfolded protein response"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    unfolded_protein_response["unfolded protein response"] -->|"active in"| thalamus["thalamus"]
    style thalamus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    unfolded_protein_response["unfolded protein response"] -->|"active in"| blood_brain_barrier["blood-brain barrier"]
    style blood_brain_barrier fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ER_stress["ER stress"] -->|"activates"| unfolded_protein_response["unfolded protein response"]
    style ER_stress fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    lipid_metabolism["lipid metabolism"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style lipid_metabolism fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    RNA["RNA"] -->|"participates in"| unfolded_protein_response["unfolded protein response"]
    style RNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IFN["IFN"] -->|"participates in"| unfolded_protein_response["unfolded protein response"]
    style IFN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"participates in"| unfolded_protein_response["unfolded protein response"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style unfolded_protein_response fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (146)

Target	Relation	Type	Str
ER homeostasis	regulates	phenotype	0.90
BAX/BCL-2 ratio	upstream_of	phenotype	0.90
macrophages	active_in	cell_type	0.90
microglia	active_in	cell_type	0.90
neurons	active_in	cell_type	0.90
thalamus	active_in	brain_region	0.90
blood-brain barrier	active_in	brain_region	0.90
astrocytes	active_in	cell_type	0.90
oligodendrocytes	active_in	cell_type	0.90
hippocampus	active_in	brain_region	0.90
endothelial cells	active_in	cell_type	0.90
cortex	active_in	brain_region	0.90
neural stem cells	active_in	cell_type	0.90
BAX	upregulates	protein	0.85
ER homeostasis	associated_with	phenotype	0.80
hypothalamus	active_in	brain_region	0.80
spinal cord	active_in	brain_region	0.80
pyramidal neurons	active_in	cell_type	0.80
aging	associated_with	phenotype	0.78
dopaminergic neurons	active_in	cell_type	0.70
substantia nigra	active_in	brain_region	0.70
T cells	active_in	cell_type	0.70
pericytes	active_in	cell_type	0.70
prefrontal cortex	active_in	brain_region	0.70
NK cells	active_in	cell_type	0.70
B cells	active_in	cell_type	0.70
white matter	active_in	brain_region	0.60
GABAergic neurons	active_in	cell_type	0.60
cerebellum	active_in	brain_region	0.60
Schwann cells	active_in	cell_type	0.60
mast cells	active_in	cell_type	0.60
dendritic cells	active_in	cell_type	0.60
interneurons	active_in	cell_type	0.60
ventral tegmental area	active_in	brain_region	0.60
cerebral cortex	active_in	brain_region	0.60
amygdala	active_in	brain_region	0.60
nucleus accumbens	active_in	brain_region	0.60

Incoming (983)

Source	Relation	Type	Str
ER stress	activates	process	0.90
lipid metabolism	crosstalk_with	pathway	0.90
RNA	participates_in	gene	0.90
IFN	participates_in	gene	0.90
ALS	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
ALS	involves	disease	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
STING	participates_in	gene	0.90
MTOR	participates_in	gene	0.90
ferroptosis	crosstalk_with	pathway	0.90
aging	involves	disease	0.90
TGF-beta signaling	crosstalk_with	pathway	0.90
frontotemporal dementia	involves	disease	0.90
neurodegeneration	involves	disease	0.90
SLC7A11	participates_in	gene	0.90
GPX4	participates_in	gene	0.90
PI3K	participates_in	gene	0.90
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.90
Parkinson's disease	involves	disease	0.90
MAPK	participates_in	gene	0.90
pyroptosis	crosstalk_with	pathway	0.90
BDNF	participates_in	gene	0.90
ROS	participates_in	gene	0.90
TNF	participates_in	gene	0.90
depression	involves	disease	0.90
glioblastoma	involves	disease	0.90
Alzheimer's disease	involves	disease	0.90
APOE	participates_in	gene	0.90
NLRP3	participates_in	gene	0.90
spinal muscular atrophy	involves	disease	0.90
cGAS-STING	crosstalk_with	pathway	0.90
DAM microglia	active_in	cell_type	0.85
microglia	active_in	cell_type	0.85
TGF	participates_in	gene	0.85
IL-10	participates_in	gene	0.85
astrocytes	active_in	cell_type	0.85
neurons	active_in	cell_type	0.85
TMEM230	regulates	gene	0.80
HSPA1A	participates_in	gene	0.80
TFEB	participates_in	gene	0.80
HIF	participates_in	gene	0.80
APOE4	participates_in	gene	0.80
PTEN	participates_in	gene	0.80
TBK1	participates_in	gene	0.80
LC3	participates_in	gene	0.80
C3	participates_in	gene	0.80
complement cascade	crosstalk_with	pathway	0.80
ATP	participates_in	gene	0.80
EGFR	participates_in	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

unfolded protein response

Understanding Entity Pages

Wiki Pages (21)