disease

nmosd

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about nmosd: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

28Outgoing

27Incoming

0Experiments

No summary available yet. View on Wiki →

Disease Info

Prevalence	1-10 per 100,000 population 4
Geographic variation	Higher prevalence in Asian, African, and Latin American populations
Age of onset	Mean 30-40 years (range: <10 to >70)
Gender distribution	Strong female predominance (F:M = 9:1)
Ethnicity	More common in non-European populations
Location	Perivascular and pial astrocyte processes
Function	Water homeostasis, glutamate clearance, potassium buffering
Expression	Highest in optic nerve, spinal cord, hypothalamus, circumventricular organs
Target	Extracellular loop of AQP4 protein
Isotype	IgG1 (complement-fixing)
Associated Genes	TREM2
KG Connections	33 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    nmosd["<b>nmosd</b>"]
    AQP4["AQP4"]
    nmosd -->|"associated with"| AQP4
    disease["disease"]
    nmosd -->|"inhibits"| disease
    AQP4["AQP4"]
    nmosd -->|"regulates"| AQP4
    AQUAPORIN_4["AQUAPORIN-4"]
    nmosd -->|"regulates"| AQUAPORIN_4
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    nmosd -->|"associated with"| MULTIPLE_SCLEROSIS
    AQP4["AQP4"]
    nmosd -->|"interacts with"| AQP4
    AQUAPORIN_4["AQUAPORIN-4"]
    nmosd -->|"interacts with"| AQUAPORIN_4
    MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    nmosd -->|"interacts with"| MULTIPLE_SCLEROSIS
    Oligodendrocyte["Oligodendrocyte"]
    nmosd -->|"interacts with"| Oligodendrocyte
    MYELIN["MYELIN"]
    nmosd -->|"interacts with"| MYELIN
    disease["disease"]
    nmosd -->|"interacts with"| disease
    Spinal_Cord["Spinal Cord"]
    nmosd -->|"interacts with"| Spinal_Cord
    Autoimmune["Autoimmune"]
    nmosd -->|"interacts with"| Autoimmune
    AQP4["AQP4"]
    nmosd -->|"activates"| AQP4
    CENTRAL_NERVOUS_SYSTEM["CENTRAL NERVOUS SYSTEM"]
    nmosd -->|"activates"| CENTRAL_NERVOUS_SYSTEM
    microglia["microglia"]
    nmosd -->|"regulates"| microglia
    MYELIN["MYELIN"]
    nmosd -->|"regulates"| MYELIN
    DEMYELINATION["DEMYELINATION"]
    nmosd -->|"regulates"| DEMYELINATION
    microglia["microglia"]
    nmosd -->|"activates"| microglia
    Macrophage["Macrophage"]
    nmosd -->|"activates"| Macrophage
    MICROGLIAL_ACTIVATION["MICROGLIAL ACTIVATION"]
    nmosd -->|"activates"| MICROGLIAL_ACTIVATION
    microglia["microglia"]
    nmosd -->|"interacts with"| microglia
    mogad["mogad"]
    mogad -->|"associated with"| nmosd
    mogad["mogad"]
    mogad -->|"interacts with"| nmosd
    mogad["mogad"]
    mogad -->|"regulates"| nmosd
    late["late"]
    late -->|"activates"| nmosd
    Neuroinflammation["Neuroinflammation"]
    Neuroinflammation -->|"regulates"| nmosd
    TREM2["TREM2"]
    TREM2 -->|"regulates"| nmosd
    TREM2["TREM2"]
    TREM2 -->|"activates"| nmosd
    TREM2["TREM2"]
    TREM2 -->|"associated with"| nmosd

Outgoing (28)

Target	Relation	Type	Str
Demyelinating Disease	involved_in	process	0.95
LETM	biomarker_for	biomarker	0.90
Optic Chiasm T2 Lesion	biomarker_for	biomarker	0.90
Area Postrema T2 Lesion	biomarker_for	biomarker	0.90
Spinal Cord Atrophy	biomarker_for	biomarker	0.90
Multiple Sclerosis	correlates_with	disease	0.85
AQP4	associated_with	gene	0.50
AQP4	regulates	gene	0.50
AQP4	interacts_with	gene	0.50
AQP4	activates	gene	0.50
disease	inhibits	disease	0.50
AQUAPORIN-4	regulates	gene	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.50
AQUAPORIN-4	interacts_with	gene	0.50
MULTIPLE SCLEROSIS	interacts_with	disease	0.50
Oligodendrocyte	interacts_with	cell_type	0.50
MYELIN	interacts_with	concept	0.50
disease	interacts_with	disease	0.50
Spinal Cord	interacts_with	cell_type	0.50
Autoimmune	interacts_with	disease	0.50
CENTRAL NERVOUS SYSTEM	activates	concept	0.50
microglia	regulates	cell_type	0.50
MYELIN	regulates	concept	0.50
DEMYELINATION	regulates	concept	0.50
microglia	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
microglia	interacts_with	cell_type	0.50

Incoming (27)

Source	Relation	Type	Str
AQP4	biomarker_for	protein	0.95
AQP4-Antibody	biomarker_for	biomarker	0.95
AQP4	associated_with	protein	0.80
MOGAD	associated_with	disease	0.80
STREM2	biomarker_for	protein	0.80
AQP4	regulates	entity	0.60
AQP4	treats	entity	0.60
MOGAD	treats	entity	0.60
MOGAD	regulates	entity	0.60
MOGAD	biomarker_for	entity	0.60
MOGAD	contributes_to	entity	0.60
AQP4	upregulates	entity	0.60
AQUAPORIN-4	regulates	entity	0.60
AQUAPORIN-4	treats	entity	0.60
NEUROINFLAMMATION	mediates	entity	0.60
NEUROINFLAMMATION	biomarker_for	entity	0.60
mogad	associated_with	disease	0.50
mogad	interacts_with	disease	0.50
mogad	regulates	disease	0.50
late	activates	disease	0.50
TREM2	regulates	gene	0.50
TREM2	activates	gene	0.50
TREM2	associated_with	gene	0.50
TREM2	interacts_with	gene	0.50
Neuroinflammation	regulates	process	0.50
Neuroinflammation	associated_with	process	0.50
Neuroinflammation	interacts_with	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

nmosd

Understanding Entity Pages

Wiki Pages (21)

Walter A. Kukull

Multiple Sclerosis (MS)

Demyelination

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Diseases

Glymphatic System in Neurodegeneration

Complement Inhibitor Therapy in Neurodegeneration

Neurosarcoidosis

AQP4 (Aquaporin-4 Gene)

BAFFR Gene (TNFRSF13C)

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)

IL-6 Protein

Rituximab

IL-6 Signaling Pathway in Neurodegeneration

Aquaporin-4 Protein

Granule Cells

Myelin Basic Protein (MBP) - Biomarker

Interleukin-6 (IL-6)

MOG Protein

AQP4 Protein — Aquaporin 4