Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SPERMIDINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SPERMIDINE |
| Key Genes/Proteins | TFEB, TAU, SIRT1, SIRT6, ATM |
| Related Diseases | MITOPHAGY, SENESCENCE, OBESITY, INSULIN_RESISTANCE, INTESTINAL_BARRIER |
| Related Pathways | AUTOPHAGY |
Knowledge base pages for this entity
graph TD
SPERMIDINE["SPERMIDINE"]
SPERMIDINE -->|"activates"| Autophagy["Autophagy"]
SPERMIDINE -.protects against.-> Aging["Aging"]
SPERMIDINE -->|"modulates"| Lifespan["Lifespan"]
SPERMIDINE -->|"modulates"| Healthspan["Healthspan"]
SPERMIDINE -->|"mediates"| Geroprotection["Geroprotection"]
SPERMIDINE -.protects against.-> Obesity["Obesity"]
SPERMIDINE -->|"treats"| Insulin_Resistance["Insulin Resistance"]
SPERMIDINE -->|"contributes to"| mitochondrial_respiratory_capa["mitochondrial respiratory capacity"]
AGING["AGING"] -->|"activates"| SPERMIDINE
INSULIN_RESISTANCE["INSULIN RESISTANCE"] -->|"activates"| SPERMIDINE
HIPPOCAMPUS["HIPPOCAMPUS"] -->|"activates"| SPERMIDINE
CASP3["CASP3"] -->|"activates"| SPERMIDINE
CORTEX["CORTEX"] -->|"activates"| SPERMIDINE| Target | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | activates | pathway | 0.72 |
| MITOPHAGY | activates | phenotype | 0.70 |
| SENESCENCE | treats | phenotype | 0.65 |
| TFEB | causes | gene | 0.65 |
| OBESITY | treats | disease | 0.64 |
| INSULIN_RESISTANCE | treats | disease | 0.64 |
| INTESTINAL_BARRIER | activates | phenotype | 0.64 |
| GUT_MICROBIOTA | regulates | phenotype | 0.64 |
| METABOLIC_ENDOTOXEMIA | inhibits | phenotype | 0.64 |
| SIRT1 | associated_with | gene | 0.50 |
| SIRT6 | associated_with | gene | 0.50 |
| ATM | associated_with | gene | 0.50 |
| MITOPHAGY | associated_with | phenotype | 0.50 |
| TFEB | associated_with | gene | 0.50 |
| SIRT3 | associated_with | gene | 0.50 |
| APP | associated_with | gene | 0.50 |
| AUTOPHAGY | associated_with | phenotype | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
| TAU | associated_with | protein | 0.45 |
| SENESCENCE | associated_with | phenotype | 0.45 |
| PINK1 | associated_with | gene | 0.45 |
| RAPAMYCIN | associated_with | drug | 0.45 |
| MTOR | associated_with | gene | 0.45 |
| IGF1 | associated_with | gene | 0.45 |
| TDP-43 | associated_with | gene | 0.45 |
| TAU | activates | protein | 0.35 |
| TAU | inhibits | protein | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAU | modifies | protein | 0.65 |
| MITOPHAGY | synergizes_with | phenotype | 0.60 |
| MITOPHAGY | targets | phenotype | 0.60 |
| CHROMATIN REMODELING | associated_with | phenotype | 0.50 |
| INSULIN RESISTANCE | associated_with | phenotype | 0.45 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
| AUTOPHAGY | associated_with | phenotype | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
| OXIDATIVE STRESS | associated_with | phenotype | 0.45 |
| AGING | activates | process | 0.35 |
| OBESITY | associated_with | disease | 0.35 |
| INSULIN RESISTANCE | activates | process | 0.35 |
| AGING | associated_with | process | 0.35 |
| HIPPOCAMPUS | activates | brain_region | 0.35 |
| CASP3 | activates | gene | 0.35 |
| CORTEX | activates | brain_region | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||