TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leading to TDP-43 pathology may differ between diseases. Understanding disease-specific drivers could reveal why TDP-43 shows limbic distribution in AD versus other patterns in ALS/FTLD. Gap type: unexplained_observation Source paper: TDP-43 Pathology in Alzheimer's Disease. (2021, Mol Neurodegener, PMID:34930382)
Landscape Summary: What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versus ALS/FTLD? is a 0.8 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versus ALS/FTLD? — INVOKE-2 (completed)
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