Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OVERVIEW: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
OVERVIEW is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, activates. Associated with ALS, Aging, Als. Connected to 1351 entities in the SciDEX knowledge graph.
| Gene Symbol | OVERVIEW |
| Pathways | Adaptive Immunity, Akt, Angiogenesis, Apoptosis, Autophagy |
| GeneCards | OVERVIEW |
| Human Protein Atlas | OVERVIEW |
| Precision | Assessment of assay reproducibility within and between laboratories using standardized protocols. |
| Accuracy | Comparison of biomarker measurements against gold-standard methods. |
| Stability | Evaluation of biomarker degradation under various pre-analytical conditions. |
| Diagnostic accuracy | Sensitivity, specificity, and predictive values for distinguishing disease from controls. |
| Disease progression markers | Correlation of biomarker levels with clinical decline and neuroimaging changes. |
| Treatment response biomarkers | Ability to detect pharmacodynamic effects and predict clinical benefit. |
| Enrichment | Selecting patients based on biomarker-positive status for targeted therapies. |
| Stratification | Subgrouping patients by biomarker profiles to identify treatment responders. |
| Endpoint selection | Using biomarker changes as surrogate endpoints for clinical outcomes. |
| Mechanistic confirmation | Demonstrating target engagement and biological activity of investigational therapies. |
| Associated Diseases | ALS, Addiction, Aging, Alzheimer, Alzheimer'S Disease |
| Interactions | VALOSIN, CHMP2B, TARDBP, LC3, TBK1, GAIN |
| KG Connections | 2317 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
OVERVIEW["OVERVIEW"] -->|"biomarker for"| Cancer["Cancer"]
OVERVIEW["OVERVIEW"] -->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
OVERVIEW["OVERVIEW"] -->|"biomarker for"| Ms["Ms"]
OVERVIEW["OVERVIEW"] -->|"therapeutic target"| Cancer_1["Cancer"]
OVERVIEW["OVERVIEW"] -->|"therapeutic target"| Neurodegeneration_2["Neurodegeneration"]
OVERVIEW["OVERVIEW"] -->|"therapeutic target"| Stroke["Stroke"]
IDH1["IDH1"] -->|"biomarker for"| OVERVIEW["OVERVIEW"]
TERT["TERT"] -->|"biomarker for"| OVERVIEW["OVERVIEW"]
JUN["JUN"] -->|"biomarker for"| OVERVIEW["OVERVIEW"]
CIC["CIC"] -->|"biomarker for"| OVERVIEW["OVERVIEW"]
style OVERVIEW fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | biomarker_for | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Stroke | therapeutic_target | disease | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Neuroinflammation | therapeutic_target | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Autoimmune | therapeutic_target | disease | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Epigenetic | therapeutic_target | pathway | 1.00 |
| Fibrosis | therapeutic_target | disease | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Immune Response | therapeutic_target | pathway | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| CANCER | biomarker_for | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Cardiovascular | therapeutic_target | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Tumor | treats | disease | 1.00 |
| Drug Resistance | therapeutic_target | pathway | 1.00 |
| Metastasis | therapeutic_target | pathway | 1.00 |
| Cancer | treats | disease | 1.00 |
| Tumor Microenvironment | therapeutic_target | pathway | 1.00 |
| Differentiation | therapeutic_target | pathway | 1.00 |
| Stem Cell | therapeutic_target | pathway | 1.00 |
| Cancer | implicated_in | disease | 1.00 |
| Neurodegeneration | implicated_in | disease | 1.00 |
| Immunotherapy | therapeutic_target | pathway | 1.00 |
| Als | treats | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| MIRNAS | regulates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| CANCER | implicated_in | gene | 1.00 |
| AGING | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
| ALZHEIMER | therapeutic_target | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| AUTOPHAGY | implicated_in | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| ALZHEIMER | implicated_in | gene | 1.00 |
| AKT | regulates | gene | 0.90 |
| GENES | regulates | gene | 0.90 |
| NF-ΚB | regulates | gene | 0.90 |
| APOPTOSIS | associated_with | gene | 0.90 |
| ALZHEIMER | associated_with | gene | 0.90 |
| PARKINSON'S DISEASE | associated_with | gene | 0.90 |
| STROKE | therapeutic_target | gene | 0.90 |
| INFLAMMATION | associated_with | gene | 0.90 |
| AUTOPHAGY | therapeutic_target | gene | 0.90 |
| APOPTOSIS | implicated_in | gene | 0.90 |
| NEURODEGENERATION | implicated_in | gene | 0.90 |
| GENES | implicated_in | gene | 0.90 |
| ALZHEIMER'S DISEASE | implicated_in | gene | 0.90 |
| AKT | implicated_in | gene | 0.80 |
| TP53 | treats | gene | 0.80 |
| EGFR | treats | gene | 0.80 |
| PTEN | therapeutic_target | gene | 0.80 |
| PI3K | regulates | gene | 0.80 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.80 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 0.80 |
| OXIDATIVE STRESS | regulates | gene | 0.80 |
| NIX | regulates | gene | 0.80 |
| ALZHEIMER'S DISEASE | activates | gene | 0.80 |
| NEURODEGENERATION | regulates | gene | 0.80 |
| CYTOKINES | regulates | gene | 0.80 |
| CANCER | associated_with | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||