PHB2

PHB2 Protein

Score: 0.337 Price: $0.34 Undruggable Druggability Status: active

HYPOTHESES

PAPERS

KG EDGES

DEBATES

3D Protein Structure

🧬 PHB2 — PDB 5XOJ Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Undruggable

Score: 0.23

Clinical Stage

Preclinical

Target Class

Protein

Safety

0.50

Druggability Analysis

Drug Development0.00

Structural Tractability0.30

Target Class0.50

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Mechanism: Prioritized from 1 SciDEX hypotheses, including: Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption

Known Drugs:

No known drugs targeting this protein

Structural Data:

PDB —AlphaFold ✓Cryo-EM —

UniProt: Q99623

🧬 3D Protein Structure

🧬 PHB2 — PDB 5XOJ Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

3D Protein Structure (AlphaFold)

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AlphaFold predicted structure available for Q99623

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Linked Hypotheses (1)

Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption0.469

Linked Experiments (0)

No linked experiments

Scoring Dimensions

Knowledge Graph (20)

co discussed (6)

TREM2→PHB2G3BP1→PHB2PHB2→TGM2PHB2→HSPG2PHB2→DNAJB6

▸ Show 1 more

PHB2→TARDBP

interacts with (14)

PEX3→PHB2PARL→PHB2BNIP3→PHB2OPTINEURIN→PHB2NLRP3→PHB2

▸ Show 9 more

G3BP1→PHB2PTEN→PHB2DISC1→PHB2MFN1→PHB2MUL1→PHB2PRKN→PHB2FUNDC1→PHB2BCL2L13→PHB2TAX1BP1→PHB2

Debate History (1)

Should PHB2 (PHB2 Protein) be prioritized as a therapeutic target for neurodegen2026-04-26