gene 1,362 words KG: TAX1BP1 2026-03-25
kind:genesection:genesstate:published
Contents

TAX1BP1 Gene

🧬 Gene Info
Gene SymbolTAX1BP1
Chromosome7p15.2
Protein TypeReceptor
FunctionMitophagy: Recognizes ubiquitinated damaged mitochondria through its UBZ domain
Primary Expressionvarious tissues with particularly high expression in immune cells and the brain
Molecular Weight90 kDa
Amino Acids789 aa
Exons14
PathwaysNF-κB
Ensembl IDENSG00000133107
GeneCardsTAX1BP1
Human Protein AtlasTAX1BP1
LIR motif (LC3-interacting region)For autophagy receptor function
Coiled-coil domainsMediate protein-protein interactions
Multiple UBDsUbiquitin-binding domains throughout
Associated DiseasesAD, ALI, ALS, AMI, Alzheimer
InteractionsFUS, ATM, SNCAIP, RB1CC1, MFN1, ERN1
KG Connections758 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

TAX1BP1 interacts_with FUS
TAX1BP1 interacts_with ATM
TAX1BP1 interacts_with SNCAIP
TAX1BP1 interacts_with RB1CC1
TAX1BP1 interacts_with MFN1
TAX1BP1 interacts_with ERN1
TAX1BP1 interacts_with PARKIN
TAX1BP1 interacts_with FMR1
TAX1BP1 interacts_with SNCA
TAX1BP1 interacts_with FAM134B