| Gene Symbol | SNAP |
| Aliases | SNAP25 |
| Chromosome | 20p12 |
| Target Class | Structural Protein |
| Function | Snap 25 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Mechanism of Action | Protein cleavage by botulinum toxin or small molecule modulators of SNARE complex formation |
| Druggability | Low (0.33) |
| Clinical Stage | Approved |
| GeneCards | SNAP |
| Human Protein Atlas | SNAP |
| N-terminal region | Contains palmitoylation sites for membrane attachment |
| SNARE motif (Habc domain) | Forms coiled-coil structure with syntaxin-1 and VAMP2 |
| C-terminal region | Two SNARE motifs (SN1 and SN2) separated by a 9-residue linker |
| SNAP-25 | Provides two alpha-helical SNARE motifs |
| Syntaxin-1 | Membrane-bound Q-SNARE on presynaptic plasma membrane |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, Alzheimer, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | RAPAMYCIN, rapamycin |
| Interactions | ACTB, STX11, ACTG1, SNCA, GAPDH, MAPK1 |
| SciDEX Target | View Target Profile (2 clinical trials) |
| SciDEX Hypotheses | Synaptic Vesicle Tau Capture Inhibition Synaptic Vesicle Tau Capture Inhibition |
| KG Connections | 629 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |