gene 815 words KG: TUBB3 2026-03-21
kind:genesection:genesstate:published
Contents

TUBB3 Gene

🧬 Gene Info
Gene SymbolTUBB3
Full NameTubulin Beta 3 Class III
Chromosome16q24.3
Protein FamilyTubulin family
Protein TypeStructural Protein
Target ClassStructural Protein
FunctionTUBB3 performs essential neuronal functions:
Mechanism of ActionSmall molecule stabilizers of microtubule structure or assembly
DruggabilityMedium (0.49)
Clinical StageApproved
Molecular Weight50 kDa
Amino Acids450 aa
PathwaysAkt, Autophagy, Cell Cycle, Pi3K, Proteasome
UniProt IDG3V3R4
Ensembl IDENSG00000198363
GeneCardsTUBB3
Human Protein AtlasTUBB3
Associated DiseasesAlzheimer, Alzheimer's disease, Anoikis Resistance, Bone Metastasis, Huntington, Huntington's disease
Known Drugs/Compoundsrapamycin
InteractionsSRC, ATG7, JUN, ACTB, NGF, VEGFA
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesQuantum Coherence Disruption in Cellular Communica
KG Connections424 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (19)

Quantum Coherence Disruption in Cellular Communication
Score: 0.34
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Circadian Clock-Autophagy Synchronization
Score: 0.55
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50

Related Analyses (7)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (2)

Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (8)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: activates
ATG7 Gene
gene · KG edge: activates
ATG14 Gene
gene · KG edge: regulates
ar
gene · KG edge: activates

Knowledge Graph (12 edges)

TUBB3 associated_with neurodegeneration
TUBB3 co_discussed CLOCK
TUBB3 co_discussed PLIN2
TUBB3 co_discussed PIEZO1
TUBB3 co_discussed GABRA1
TUBB3 co_discussed G3BP1
TUBB3 inhibits SRC
TUBB3 associated_with STK11
TUBB3 associated_with VIM
TUBB3 regulates BECN1