| Gene Symbol | YKL |
| Full Name | 40 (CHI3L1) - Biomarker |
| Aliases | CHI3L1 |
| Chromosome | 1q32.1 |
| Function | YKL-40, also known as chitinase 3-like protein 1 (CHI3L1), is a secreted glycoprotein belonging to the glycoside hydrolase family 18[@chitinase2020]. |
| GeneCards | YKL |
| Human Protein Atlas | YKL |
| Cutoff values differ by population | Japanese studies suggest 90 ng/mL CSF cutoff vs. 80 ng/mL for Western cohorts |
| APOE ε4 interaction | YKL-40 elevation more pronounced in APOE ε4 carriers across all Asian populations |
| Vascular comorbidity | Higher baseline YKL-40 in subjects with small vessel disease (common in East Asian populations) |
| Associated Diseases | Als, Alzheimer, Fibrosis, Inflammation, Neuroinflammation, neurodegeneration |
| Known Drugs/Compounds | hygromycin B |
| Interactions | AQP4, GBM, STAT3, RAGE, APP, JAK1 |
| SciDEX Hypotheses | Integrated Biomarker Panel for Therapeutic Window |
| KG Connections | 360 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |