Contents

CACNA1G Gene

🧬 Gene Info

Gene Symbol	CACNA1G
Full Name	Calcium Voltage-Gated Channel Subunit Alpha1 G
Chromosome	17q22
Protein Type	Ion Channel
Target Class	Ion Channel
Function	The CACNA1G gene encodes the α1G subunit that forms the pore of the T-type (low-voltage activated) calcium channel (CaV3.1).
Mechanism of Action	Small molecule blocker of T-type calcium channel activity
Druggability	High (0.90)
Clinical Stage	Approved
Molecular Weight	262 kDa
Pathways	Synaptic function / plasticity
UniProt ID	O43497
NCBI Gene ID	8912
Ensembl ID	ENSG00000006283
GeneCards	CACNA1G
Human Protein Atlas	CACNA1G
Associated Diseases	absence seizures, Ataxia, Autism, epilepsy, Huntington's disease
Known Drugs/Compounds	Nnc-55-0396, SAK3
Interactions	AND, ANK3, APC, APP, ARID1A, ASXL1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Sleep Spindle-Synaptic Plasticity Enhancement
KG Connections	302 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph