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mechanism 1,304 words KG: disease
Contents

Cerebrovascular Disease in Neurodegeneration

⚙ Mechanism Info
Namedisease
Key Genes/Proteins4r-tau, A2M, ABCA1, ABCA7, ABCB1, ABCD3
Related Diseasesacetylcholine
Linked Hypotheses45 hypotheses

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Related Hypotheses (43)

Closed-loop transcranial focused ultrasound to restore hippo
Score: 0.00Closed-loop transcranial focused ultrasound targeting EC-II
Score: 0.97Closed-loop transcranial focused ultrasound to restore hippo
Score: 0.91Optogenetic restoration of hippocampal gamma oscillations vi
Score: 0.87Closed-loop transcranial focused ultrasound to restore hippo
Score: 0.83Closed-loop transcranial focused ultrasound to restore hippo
Score: 0.82MAPT tau seeding and release across AD, FTD, and PD-spectrum
Score: 0.81Closed-loop transcranial focused ultrasound targeting CA1 PV
Score: 0.80Closed-loop tACS targeting entorhinal cortex layer II SST in
Score: 0.78Closed-loop transcranial focused ultrasound to restore hippo
Score: 0.77VPS35 retromer activation prevents endosomal tau templating
Score: 0.74Excessive C1q/C3/CR3 complement cascade activation initiates
Score: 0.72Closed-loop transcranial focused ultrasound targeting EC-II
Score: 0.71TREM2 haploinsufficiency dysregulates microglial synaptic su
Score: 0.70Alpha-synuclein phosphorylation-dominated LLPS hijacks synap
Score: 0.66Microglial TREM2 downregulation impairs damage-associated re
Score: 0.63Optogenetic viral vector delivery via tFUS-mediated blood-br
Score: 0.62CSF ApoE- and clusterin-rich lipoprotein particles stabilize
Score: 0.61microglial priming as a partially upstream causal node rathe
Score: 0.60Direct ISR target engagement likely requires trazodone doses
Score: 0.59
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Knowledge Graph (12 edges)

SLC16A2 implicated_in disease
SLC16A1 implicated_in disease
GSS implicated_in disease
CYP2E1 implicated_in disease
AKT1 activates disease
ATF6 activates disease
ATG16L1 activates disease
CGAS activates disease
CFTR activates disease
CASP3 activates disease

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