Contents

CHEK1 Gene

🧬 Gene Info

Gene Symbol	CHEK1
Full Name	Checkpoint Kinase 1
Chromosome	11q24.2
Protein Type	Serine/Threonine Kinase
Function	CHEK1 (Checkpoint Kinase 1) is a serine/threonine kinase that plays a central role in the DNA damage response (DDR).
Molecular Weight	56 kDa
Amino Acids	476 aa
Pathways	Akt, Pi3K
UniProt ID	CHEK1
Ensembl ID	ENSG00000149554
OMIM	604603
GeneCards	CHEK1
Human Protein Atlas	CHEK1
DNA Damage Checkpoint	Halts cell cycle progression for DNA repair
Replication Fork Stability	Prevents replication fork collapse
Associated Diseases	Als, Ataxia, Infection
Known Drugs/Compounds	Thiabendazole
Interactions	CDK1, CDK2, EGFR, AND, CANCER, P53
KG Connections	71 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph