Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Complement component C4A gene - role in neuroinflammation, synaptic pruning, and neurodegenerative diseases including Alzheimer's and schizophrenia
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| Gene Symbol | C4A |
| Full Name | Complement Component 4A (Chido/Rodgers Blood Group) |
| Aliases | Complement component C4A gene, Complement Component 4A |
| Chromosome | 6p21.3 |
| Function | encodes a critical protein in the classical complement cascade, a key component of the innate immune system. |
| Molecular Weight | 104 kDa |
| Amino Acids | 1741 aa |
| UniProt ID | P0C0P0 |
| NCBI Gene ID | 712 |
| Ensembl ID | ENSG00000144711 |
| OMIM | 120810 |
| GeneCards | C4A |
| Human Protein Atlas | C4A |
| Associated Diseases | Als |
| Interactions | C4, C4B, PSP |
| KG Connections | 37 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
C4A["<b>C4A</b>"]
Ms{"Ms"}
C4A -->|"expressed in"| Ms
Schizophrenia{"Schizophrenia"}
C4A -->|"expressed in"| Schizophrenia
Als{"Als"}
C4A -->|"expressed in"| Als
C4A -->|"associated with"| Als
ALS{"ALS"}
C4A -->|"expressed in"| ALS
C4B["C4B"]
C4A -->|"expressed in"| C4B
Complement(["Complement"])
C4A -->|"expressed in"| Complement
C4A -->|"associated with"| Complement
SYNAPSE["SYNAPSE"]
C4A -->|"expressed in"| SYNAPSE
AND["AND"]
C4A -->|"expressed in"| AND
GENES["GENES"]
C4A -->|"expressed in"| GENES
COMPLEMENT["COMPLEMENT"]
C4A -->|"expressed in"| COMPLEMENT
C4B -->|"expressed in"| C4A
GENES -->|"expressed in"| C4A
COMPLEMENT -->|"expressed in"| C4A
style C4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Schizophrenia | risk_factor_for | disease | 0.93 |
| Als | associated_with | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| PSP | regulates | gene | 0.60 |
| STX6 | regulates | gene | 0.60 |
| PSP | interacts_with | gene | 0.60 |
| PSP | causes | gene | 0.60 |
| STX6 | causes | gene | 0.60 |
| SYNAPSE | expressed_in | gene | 0.60 |
| MAPT | regulates | gene | 0.60 |
| RUNX2 | causes | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| COMPLEMENT | expressed_in | gene | 0.60 |
| SCHIZOPHRENIA | expressed_in | entity | 0.60 |
| MOBP | regulates | gene | 0.60 |
| RUNX2 | regulates | gene | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| MOBP | causes | gene | 0.60 |
| Complement | expressed_in | pathway | 0.60 |
| schizophrenia | interacts_with | disease | 0.60 |
| complement cascade | participates_in | pathway | 0.60 |
| Complement | associated_with | pathway | 0.60 |
| C4B | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| C4B | interacts_with | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| C4B | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity