| Gene Symbol | DUSP1 |
| Full Name | Dual Specificity Phosphatase 1 |
| Chromosome | 5q33.1 |
| Protein Type | Phosphatase |
| Function | is a critical negative regulator of MAPK signaling that dephosphorylates and inactivates MAPK family members including ERK, JNK, and p38[@avraham2022]. |
| Molecular Weight | 40 kDa |
| Amino Acids | 367 aa |
| Pathways | MAPK signaling, MAPK, MAPK pathway |
| UniProt ID | [P28562](https://www.uniprot.org/uniprot/P28562) |
| Ensembl ID | ENSG00000120129 |
| OMIM | 603067 |
| GeneCards | DUSP1 |
| Human Protein Atlas | DUSP1 |
| ERK1/2 dephosphorylation | Inactivates ERK1/2 signaling, terminating proliferation and differentiation signals |
| JNK dephosphorylation | Reduces stress-activated pro-apoptotic signaling |
| Associated Diseases | Encephalitis, Fibrosis, Ms, Multiple Sclerosis, Myeloma, Tumor |
| Interactions | AND, App, BAX, CCND1, CDKN1A, CGAS |
| KG Connections | 127 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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